Gastric collision tumour with probable ectopic pancreatic origin

Abstract

Introduction Mixed histology tumours are rarely found in the stomach. Of these, collision tumours are mainly composed of adenocarcinomas and sarcomas or lymphomas. This is the seventh case reported in the literature of an acinar cell carcinoma arising from an ectopic pancreas located in the stomach and the first described within a collision tumour. Clinical case We present the case of a 58-year-old female patient diagnosed with gastric cancer who, after undergoing a total gastrectomy, presented with a pathology report describing findings compatible with gastric collision tumour with components of tubular adenocarcinoma and acinar cell carcinoma of probable pancreatic ectopic aetiology. Discussion At the beginning of the 20th century, collision tumours were rarely described. Those located in the stomach are an infrequent pathology and are rarely diagnosed preoperatively. A collision tumour is composed of two independent neoplastic tissue with tumour areas separated in two different histological patterns and, in case of metastasis, this separation must also be clearly identified. There are different theories about its carcinogenesis and the debate regarding the ideal treatment is still ongoing. Conclusion This is the first report of a malignant gastric tumour with probable heterotopic pancreatic origin that collides with gastric adenocarcinoma.

Successful surgery with preservation of laryngeal function in a patient with collision primary squamous cell carcinoma and adenoid cystic carcinoma in the hypopharynx and synchronous esophageal carcinoma: A case report

“…A third idea is that a carcinogen triggers a second tumor over an existing tumor 24 . All of these hypotheses seem appropriate for the development of a gastric collision tumor 23 . In terms of thyroid collision tumors, 25 there are other ideas.…”

“…The first hypothesis was an accidental encounter of two neoplasms that developed independently but eventually collided 22 . Another idea is that a common carcinogen may trigger the development of two adjacent synchronous neoplasms 23 . A third idea is that a carcinogen triggers a second tumor over an existing tumor 24 .…”

“…22 Another idea is that a common carcinogen may trigger the development of two adjacent synchronous neoplasms. 23 A third idea is that a carcinogen triggers a second tumor over an existing tumor. 24 All of these hypotheses seem appropriate for the development of a gastric collision tumor.…”

“…24 All of these hypotheses seem appropriate for the development of a gastric collision tumor. 23 In terms of thyroid collision tumors, 25 there are other ideas. One tumor may predispose to the development of another tumor; stem cells may be involved; or there may be a random collision.…”