Phase I Dose-Escalation Study of Stereotactic Body Radiation Therapy for Low- and Intermediate-Risk Prostate Cancer

Boike, Thomas; Lotan, Yair; Cho, L. Chinsoo; Brindle, Jeffrey; DeRose, Paul; Xie, Xian Jin; Yan, Jingsheng; Foster, Ryan; Pistenmaa, David; Perkins, Alida; Cooley, Susan; Timmerman, Robert

doi:10.1200/jco.2010.31.4377

Cited by 228 publications

(194 citation statements)

References 30 publications

Supporting

Mentioning

182

Contrasting

Unclassified

Order By: Relevance

“…25,27,28 So, there is no reason to think that AEs would be seen with longer follow-up. Furthermore, most grade-3 events in the University of Texas Southwestern study 19 and the Georgetown University study 21 were seen within 12 months. With a median follow-up of 18 months, the present study should reflect most AEs for this technique.…”

Section: Discussionmentioning

confidence: 99%

“…18 Clinical results for hypofractionated photon prostate cancer treatments have also been favorable. 3,[19][20][21][22][23][24][25][26][27][28][29][30][31] Many different fractionations, from 6.75 Gy in 5 treatments to 10 Gy in 5 treatments, have been used. Our design was based on data published with high-dose-rate brachytherapy for prostate cancer and the published normal tissue ˛/ř atio.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Image-guided hypofractionated proton beam therapy for low-risk prostate cancer: Analysis of quality of life and toxicity, PCG GU 002

Vargas

Hartsell²,

Dunn

et al. 2016

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Image-guided hypofractionated proton beam therapy for low-risk prostate cancer: Analysis of quality of life and toxicity, PCG GU 002

Vargas

Hartsell²,

Dunn

et al. 2016

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

“…Nevertheless, the precision of SBRT tracking strategies using fiducial markers permitted the reduction of PTV margin with increased reproducibility (57). A rectal balloon to minimize prostate motion was equally effective (58), thus suggesting the possibility of using similar strategies in cervical radiotherapy. Likewise, the non-invasive ultrasound online tracking was successfully used in prostate radiotherapy (59), and recently, proven to be efficient in cervical cancer tracking for daily IMRT (60).…”

Section: Lessons Learned From Other Tumors To Improve the Ebrt Delivementioning

confidence: 99%

External beam techniques to boost cervical cancer when brachytherapy is not an option—theories and applications

Mahmoud¹,

Kilic²,

Khan³

et al. 2017

Ann. Transl. Med.

View full text Add to dashboard Cite

The management of locally advanced cervical cancer relies on brachytherapy (BT) as an integral part of the radiotherapy delivery armamentarium. Occasionally, intracavitary BT is neither possible nor available. In these circumstances, post-external beam radiotherapy (EBRT) interstitial brachytherapy and/or hysterectomy may represent viable options that must be adequately executed in a timely manner. However, if these options are not applicable due to patient related or facility related reasons, a formal contingency plan should be in place. Innovative EBRT techniques such as intensity modulated and stereotactic radiotherapy may be considered for patients unable to undergo brachytherapy. Relying on provocative arguments and recent data, this review explores the rationale for and limitations of non-brachytherapy substitutes in that setting aiming to establish a formal process for the optimal execution of this alternative plan.

show abstract

“…The CTV expansion excluded the bladder and rectum. Planning target volume (PTV) expansions were a 3-mm uniform expansion of the CTV consistent with previous series reporting on hypofractionated prostate radiotherapy [6]. All patients were treated with the Elekta Axesse linear accelerator with onboard KV CBCT (Elekta Oncology Systems, Stockholm, Sweden).…”

Section: Methodsmentioning

confidence: 99%

Determinants of intrafraction variation during image-guided hypofractionated radiotherapy of the prostate

et al. 2012

View full text Add to dashboard Cite

Purpose The purpose of this study is to examine intrafraction variation and residual error (IFV+RE) during conebeam CT (CBCT)-guided hypofractionated prostate radiotherapy and evaluate factors associated along with target margins. Materials and methods Forty-six patients underwent hypofractionated prostate radiotherapy receiving 64 Gy in 20 fractions with on-line CBCT correction. Analysis of factors associated with IFV+RE including patient characteristics, treatment characteristics, and organ volumes was performed using univariate and multivariate analyses. Results The mean IFV+RE were 0.10±1.1, −1.1±2.5, and −1.5 ±2.7 mm in the mediolateral (ML), anteroposterior (AP), and craniocaudad (CC) dimensions, respectively. The IFV+RE vector was 3.5±2.5 mm. It was found that 1, 22, and 31 % of fractions had an IFV+RE greater than 3 mm in the ML, AP, and CC dimensions, respectively. Multivariate analysis found that age and rectal volumes are associated with increased IFV+RE. When evaluating IFV+RE greater than 3 mm, age, treatment time, and rectal volumes were associated. A treatment time of greater than 16.5 min was found to be a cut point for increased IFV+RE. Conclusions IFV may represent a significant component of target margins utilized in hypofractionated prostate radiotherapy with target margins exceeding 3 mm in the CC and AP dimensions. Rectal volumes, treatment time, and age are associated with IFV+RE.

show abstract

Phase I Dose-Escalation Study of Stereotactic Body Radiation Therapy for Low- and Intermediate-Risk Prostate Cancer

Abstract: Dose escalation to 50 Gy has been completed without DLT. A multicenter phase II trial is underway treating patients to 50 Gy in five fractions to further evaluate this experimental therapy.

Cited by 228 publications

References 30 publications

Image-guided hypofractionated proton beam therapy for low-risk prostate cancer: Analysis of quality of life and toxicity, PCG GU 002

Image-guided hypofractionated proton beam therapy for low-risk prostate cancer: Analysis of quality of life and toxicity, PCG GU 002

External beam techniques to boost cervical cancer when brachytherapy is not an option—theories and applications

Determinants of intrafraction variation during image-guided hypofractionated radiotherapy of the prostate

Contact Info

Product

Resources

About