Phase equilibria in phospholipid-water systems

Thermotropic phase behaviour of the pseudobinary mixtures of DPPC/C12E5 and DMPC/C12E5 determined by differential scanning calorimetry and ultrasonic velocimetry

“…If two amphiphilic components are considered, the system is called pseudobinary. However, such pseudobinary behaviour must be checked for every new system and cannot be assumed in advance (see also Chernik, 1995).…”

Dielectric Study of Liposome Dispersion Using Statistical Analysis of Jitter

“…The dashed line in Fig. 3 shows the gel-LC transition temperature of DPPC bilayer determined by DSC [6]. The relaxation strength and the relaxation time showed similar temperature dependence to decrease with increasing temperature from 36 o C to 48 o C. However, the relaxation time distribution parameter, β, did not clearly show any temperature dependence in the gel phase, whereas it decidedly decreased above the gel-LC phase transition temperature 41 o C. According to our former results, the values of τ for DPPC liposome water dispersion decreased with increasing temperature, and the values of ε and β show discontinuous changes around the gel-LC phase transition temperature [14].…”

“…Physical properties of the lipid bilayer are affected by temperature, concentration, stresses, and so on [5]. In the case of, Dipalmitoyl Phosphatidylcholine (DPPC), the lipid membrane changes the regularity of lipid molecules on the membrane interface at 35.8 o C, and the membrane tenderness absolutely changes with alkyl chain melting at 41.6 o C observed by Differential Scanning Calorimetry (DSC) measurement [6].…”

Trends and demands in the solid–liquid equilibrium of lipidic mixtures

“…The eutectic point in this case establishes a triphasic equilibrium in which the liquid phase is in equilibrium with two solid solutions with 105 distinct compositions. The evaluation of the eutectic point and the solubility region of the solid phase is usually carried out using the Tammann plot ( Figure 3) [50][51][52][53] . This diagram relates the enthalpy of the eutectic reaction as a function of the mixture concentration in which the enthalpy rises up to the eutectic point when it begins 110 to decrease.…”

“…Moreover, beyond these binary fatty systems, many works in literature, aiming at the design of products and processes, have been evaluating the SLE of binary systems of 30 these fatty compounds with other organic solvents such as cyclohexane and ethanol 77 , alkanes 78 , aromatic compounds 79 and drugs 80 . Additionally, the SLE of many lipid-derivative based mixtures composed of surfactants 81 , phospholipids 53 , glycolipids 82 , lipidic-based ionic liquids 83 or aqueous mixtures 35 of partial acylglycerols 84 have also been reported, aiming at formulation of food or personal care products, supporting media 85 , or drug delivery systems 86 . These mixtures display a set of liquid crystalline states or mesophases.…”