Phase contrast surface mode resonance microscopy

Herminghaus, Stephan; Bechinger, Clemens; Petersen, Wesley P.; Leiderer, Paul

doi:10.1016/0030-4018(94)90072-8

Cited by 13 publications

(6 citation statements)

References 29 publications

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“…As early as in 1976, Abeles [13] had figured out a theoretical description of dependence of phase difference on the wave vector along the surface of the Kretschmann configuration, and proposed the adoption of ellipsometry for investigating surface or interface reactions. In 1990s, Herminghaus [70] used phase-polarization properties of light to improve the contrast of SPR microscopy and employ it for the characterization of thin films. Kabashin [71,72] studied phase and polarization transformations under SPR and proposed to exploit SPR-related phase jump as a resonant point marker to considerably improve the contrast of the signal pattern in conventional SPR bio-and chemical sensing.…”

Section: Polarimetrymentioning

confidence: 99%

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

et al. 2012

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International audienceSurface Plasmon Resonance (SPR) has become a central tool for label-free characterization of biomolecular interactions. Based on monitoring of amplitude characteristics, conventional SPR sensors have been extensively explored, commercialized and applied for studies of many important interactions (antigen-antibody, protein-ligand etc), but this technology still lacks of sensitivity for the detection of relatively small and low copy number compounds. Phase-sensitive SPR has recently emerged as an upgrade of this technology to resolve the sensitivity issue. Profiting from a sharp phase jump under SPR and ultra-sensitive tools of its control, this technology offers up to 100-time improvement of the detection limit, giving access to the detection of trace amounts of small molecular weight analytes (drugs etc). This paper intends to provide a tutorial on basic concepts of phase detection in SPR sensing, compare the performance of phase- and amplitude-sensitive sensors, review recent progress in the development and applications of phase-sensitive SPR sensors, and outline future prospects and trends of this technology

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Section: Polarimetrymentioning

confidence: 99%

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

et al. 2012

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“…15 Since infinitesimally small changes of system parameters can result in totally different phase behavior, one may anticipate here a large potential for an improvement of the performance of SPR-based imaging and sensor methods. Later we show that the SPR phase jump and the strong dependence of the SPR phase upon system parameters ͑for example, optical thickness͒ can be used to improve the sensitivity of the SPR microscopy technique [16][17][18] and develop interferometric SPR imaging ͑ISPRI͒ with monoatomic thickness and micrometer spatial resolutions. For this, we combine a SPR interferometer 14 with a conventional SPR microscope 16 by an introduction of an additional reference beam, which interferes with the SPR signal beam.…”

mentioning

confidence: 94%

Phase jumps and interferometric surface plasmon resonance imaging

Григоренко

Никитин

Kabashin

1999

Applied Physics Letters

150

106

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“…Regions of the sample having the correct optical thickness to support an optical waveguide mode at a chosen angle of incidence will appear dark in reflection, while other areas will appear bright (Fig. 1, A and B) (12,13). We sought to apply this experimental system to single living cells.…”

mentioning

confidence: 99%

Optical Measurements of Invasive Forces Exerted by Appressoria of a Plant Pathogenic Fungus

Bechinger¹,

Giebel²,

Schnell³

et al. 1999

Science

249

142

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Many plant pathogenic fungi, such as the cereal pathogen Colletotrichum graminicola , differentiate highly specialized infection structures called appressoria, which send a penetration peg into the underlying plant cell. Appressoria have been shown to generate enormous turgor pressure, but direct evidence for mechanical infection of plants by fungi is lacking. A microscopic method was developed that uses elastic optical waveguides to visualize and measure forces locally exerted by single appressoria. By this method, the force exerted by appressoria of C. graminicola was found to be about 17 micronewtons.

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Phase contrast surface mode resonance microscopy

Abstract: Abstract

Cited by 13 publications

References 29 publications

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Phase jumps and interferometric surface plasmon resonance imaging

Optical Measurements of Invasive Forces Exerted by Appressoria of a Plant Pathogenic Fungus

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