Phase-change composite filled natural nanotubes in hydrogel promote wound healing under photothermally triggered drug release

Ye, Jingjing; Li, Longfei; Hao, Ruinan; Gong, Mali; Wang, Tong; Song, Jian; Meng, Qinghan; Zhao, Nana; Xu, Fu-Jian; Lvov, Yuri; Zhang, Liqun; Xue, Jiajia

doi:10.1016/j.bioactmat.2022.08.026

Cited by 25 publications

(17 citation statements)

References 55 publications

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“…It can be seen that the expression of CD31 in PCL@PDA-ε-PL, 30%-Janus-Without NIR, and 30%-Janus-With NIR groups was higher than that in the control and 3 M Tegaderm film groups. The improved angiogenesis was mainly associated with the effect of anti-inflammatory IBU, since inflammation during wound healing could inhibit blood vessel formation . Thus, the nanofiber membrane groups exhibited better wound healing effects during the postsurgery treatment, especially the 30%-Janus-With NIR group, which showed the best healing capacity.…”

Section: Resultsmentioning

confidence: 91%

“…The improved angiogenesis was mainly associated with the effect of anti-inflammatory IBU, since inflammation during wound healing could inhibit blood vessel formation. 68 Thus, the nanofiber membrane groups exhibited better wound healing effects during the postsurgery treatment, especially the 30%-Janus-With NIR group, which showed the best healing capacity.…”

Section: Cytotoxicity and In Vitro Anti-inflammatory Assaymentioning

confidence: 88%

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Phase Change Material-Embedded Multifunctional Janus Nanofiber Dressing with Directional Moisture Transport, Controlled Release of Anti-Inflammatory Drugs, and Synergistic Antibacterial Properties

Liu,

Huang,

Liang

et al. 2023

ACS Appl. Mater. Interfaces

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Wound healing is a systematic and complex process that involves various intrinsic and extrinsic factors affecting different stages of wound repair. Therefore, multifunctional wound dressings that can modulate these factors to promote wound healing are in high demand. In this work, a multifunctional Janus electrospinning nanofiber dressing with antibacterial and anti-inflammatory properties, controlled release of drugs, and unidirectional water transport was prepared by depositing coaxial nanofibers on a hydrophilic poly(ε-caprolactone)@polydopamine-ε-polyl-lysine (PCL@PDA-ε-PL) nanofiber membrane. The coaxial nanofiber was loaded with the phase change material lauric acid (LA) in the shell layer and anti-inflammatory ibuprofen (IBU) in the core layer. Among them, LA with a melting point of 43 °C served as a phase change material to control the release of IBU. The phase transition of LA was induced by near-infrared (NIR) irradiation that triggered the photothermal properties of PDA. Moreover, the Janus nanofiber dressing exhibited synergistic antimicrobial properties for Escherichia coli and Staphylococcus aureus due to the photothermal properties of PDA and antibacterial ε-PL. The prepared Janus nanofiber dressing also exhibited anti-inflammatory activity and biocompatibility. In addition, the Janus nanofiber dressing had asymmetric wettability that enabled directional water transport, thereby draining excessive wound exudate. The water vapor transmission test indicated that the Janus nanofiber dressing had good air permeability. Finally, skin wound healing evaluation in rats confirmed its efficacy in promoting wound healing. Therefore, this strategy of designing and manufacturing a multifunctional Janus nanofiber dressing had great potential in wound healing applications.

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Section: Resultsmentioning

confidence: 91%

Section: Cytotoxicity and In Vitro Anti-inflammatory Assaymentioning

confidence: 88%

Phase Change Material-Embedded Multifunctional Janus Nanofiber Dressing with Directional Moisture Transport, Controlled Release of Anti-Inflammatory Drugs, and Synergistic Antibacterial Properties

Liu,

Huang,

Liang

et al. 2023

ACS Appl. Mater. Interfaces

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“…149 Meanwhile, the hydrogel maintains a stable rate of drug release over a long period of time (ranging from hours to months), which is conducive to reducing the doses required to treat patients over time. 150 Ye et al 151 prepared antibacterial composite hydrogels with efficient NIR triggered drug release by encapsulating antimicrobial drugs (rifampicin), NIR-absorbing dye (indocyanine green) and phase change materials (eutectic mixture of fatty acids) into halloysite nanotubes, and incorporating them into alginate hydrogels. Meanwhile, the use of a phase change material with a melting point of 39 °C facilitated the gel response to the NIR-triggered drug release.…”

Section: Translational Application Of Antibacterial Hydrogelsmentioning

confidence: 99%

Recent progress of antibacterial hydrogel materials for biomedical applications

Wang,

Feng,

et al. 2023

J. Mater. Chem. C

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“…By exploiting the different chemical composition and the different surface charges, HNTs can be modified, resulting in different nanomaterials with tunable properties that have found applications as fillers in polymeric matrices [ 17 , 18 , 19 ], drug carriers and delivery systems [ 20 , 21 ], supports for metal nanoparticles for catalytic purposes [ 22 , 23 , 24 , 25 ], and so on [ 26 , 27 ] ( Figure 5 a,b). The growing number of halloysite-related publications and patents attests to the clay’s growing popularity.…”

Section: Halloysite Nanotubes Based Antimicrobial Materialsmentioning

confidence: 99%

Antimicrobial Nanomaterials Based on Halloysite Clay Mineral: Research Advances and Outlook

Massaro¹,

Ciani²,

Cinà³

et al. 2022

Antibiotics

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Bacterial infections represent one of the major causes of mortality worldwide. Therefore, over the years, several nanomaterials with antibacterial properties have been developed. In this context, clay minerals, because of their intrinsic properties, have been efficiently used as antimicrobial agents since ancient times. Halloysite nanotubes are one of the emerging nanomaterials that have found application as antimicrobial agents in several fields. In this review, we summarize some examples of the use of pristine and modified halloysite nanotubes as antimicrobial agents, scaffolds for wound healing and orthopedic implants, fillers for active food packaging, and carriers for pesticides in food pest control.

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Phase-change composite filled natural nanotubes in hydrogel promote wound healing under photothermally triggered drug release

Cited by 25 publications

References 55 publications

Phase Change Material-Embedded Multifunctional Janus Nanofiber Dressing with Directional Moisture Transport, Controlled Release of Anti-Inflammatory Drugs, and Synergistic Antibacterial Properties

Phase Change Material-Embedded Multifunctional Janus Nanofiber Dressing with Directional Moisture Transport, Controlled Release of Anti-Inflammatory Drugs, and Synergistic Antibacterial Properties

Recent progress of antibacterial hydrogel materials for biomedical applications

Antimicrobial Nanomaterials Based on Halloysite Clay Mineral: Research Advances and Outlook

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