Antimicrobial Nanomaterials Based on Halloysite Clay Mineral: Research Advances and Outlook

Massaro, Marina; Ciani, Rebecca; Cinà, Giuseppe; Colletti, Carmelo Giuseppe; Leone, Frédéric; Riela, Serena

doi:10.3390/antibiotics11121761

Cited by 8 publications

(3 citation statements)

References 92 publications

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“…Previous studies have demonstrated that halloysite clay nanotubes effectively penetrate cell membranes due to their small cross-section [12]. In this case, halloysite penetrability is defined by their tens of nanometers diameter rather than their sub-micrometer length (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Clay Nanotubes Loaded with Diazepam or Xylazine Permeate the Brain through Intranasal Administration in Mice

Yanamadala

Williams

Lvov

et al. 2023

IJMS

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The blood–brain barrier (BBB) is an obstacle to the permeation of most therapeutic drugs into the brain, limiting treatments for neurological disorders. Drugs loaded within nanocarriers that pass through the BBB can overcome this limitation. Halloysite consists of naturally occurring biocompatible clay nanotubes of 50 nm diameter and 15 nm lumen, allowing the loading and sustained release of loaded drugs. These have demonstrated the ability to transport loaded molecules into cells and organs. We propose to use halloysite nanotubes as a “nano-torpedo” for drug delivery through the BBB due to their needle-like shape. To determine if they can cross the BBB using a non-invasive, clinically translatable route of administration, we loaded halloysite with either diazepam or xylazine and delivered these intranasally to mice daily over six days. The sedative effects of these drugs were observed in vestibulomotor tests conducted at two, five, and seven days after the initial administration. Behavioral tests were conducted 3.5 h after administration to show that the effects were from halloysite/delivered drugs and not from the drug alone. As expected, the treated mice performed more poorly than the sham, drug alone, and halloysite-vehicle-treated mice. These results confirm that halloysite permeates the BBB to deliver drugs when administered intranasally.

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Section: Introductionmentioning

confidence: 99%

Clay Nanotubes Loaded with Diazepam or Xylazine Permeate the Brain through Intranasal Administration in Mice

Yanamadala

Williams

Lvov

et al. 2023

IJMS

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“…Based on the advantageous properties of the clays and clay minerals-ion exchange, adsorption, swelling, and rheological behavior-and their use as support [11][12][13][14][15], the pharmaceutical and cosmetic industries have an increasing interest in incorporating these materials to their products. In this sense, a special emphasis has been made in natural resources by their abundance, low cost, and environmental friendliness [16][17][18][19]. Thus, it is worth underlining the employment of clays in skin care formulations [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Efficacy and “In Vivo” Safety of a Bentonite/Vitamin C Hybrid

et al. 2023

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L-ascorbic acid (LAA), commonly known as vitamin C, is an excellent and recognized antioxidant molecule used in pharmaceutical and cosmetic formulations. Several strategies have been developed in order to preserve its chemical stability, connected with its antioxidant power, but there is little research regarding the employment of natural clays as LAA host. A safe bentonite (Bent)—which was verified by in vivo ophthalmic irritability and acute dermal toxicity assays—was used as carrier of LAA. The supramolecular complex between LAA and clay may constitute an excellent alternative, since the molecule integrity does not seem to be affected, at least from the point of view of its antioxidant capacity. The Bent/LAA hybrid was prepared and characterized through ultraviolet (UV) spectroscopy, X-ray diffraction (XRD), infrared (IR) spectroscopy, thermogravimetric analysis (TG/DTG) and zeta potential measurements. Photostability and antioxidant capacity tests were also performed. The LAA incorporation into Bent clay was demonstrated, as well as the drug stability due to the Bent photoprotective effect onto the LAA molecule. Moreover, the antioxidant capacity of the drug in the Bent/LAA composite was confirmed.

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“…[11] Clay minerals, because of their high biocompatibility, high availability, and low cost, represent emerging materials for application in biomedical field. [12,13] In the last years, there has been an increasing interest in the utilization of clay minerals not only as excipients in pharmacological formulations but also as active ingredients for the delivery of different drugs. [14][15][16] In this context, halloysite, a clay mineral with a typical hollow tubular structure, holds several advantages for biomedical applications.…”

mentioning

confidence: 99%

Nanoformulations based on collagenases loaded into halloysite/Veegum® clay minerals for potential pharmaceutical applications

Massaro

Ghersi

Barbosa

et al. 2023

Colloids and Surfaces B: Biointerfaces

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Antimicrobial Nanomaterials Based on Halloysite Clay Mineral: Research Advances and Outlook

Cited by 8 publications

References 92 publications

Clay Nanotubes Loaded with Diazepam or Xylazine Permeate the Brain through Intranasal Administration in Mice

Clay Nanotubes Loaded with Diazepam or Xylazine Permeate the Brain through Intranasal Administration in Mice

Antioxidant Efficacy and “In Vivo” Safety of a Bentonite/Vitamin C Hybrid

Nanoformulations based on collagenases loaded into halloysite/Veegum® clay minerals for potential pharmaceutical applications

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