Phase behavior of fully hydrated DMPC-amphiphilic cyclodextrin systems

Lesieur, Sylviane; Charon, Daniel; Lesieur, P.; Ringard-Lefebvre, Catherine; Muguet, V.; Duchêne, Dominique; Wouessidjewe, Denis

doi:10.1016/s0009-3084(00)00149-3

Cited by 52 publications

(30 citation statements)

References 38 publications

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“…At 303 K, L α phase is characterized by d-spacing 6.3 and 3.17 nm. These values are in good agreement with the results of previous studies [6,30,31]. The temperature dependence of the lamellar lattice constant d of fully hydrated DMPC dispersion and the DMPC-Gcyclo mixtures is presented in Fig.…”

Section: Resultssupporting

confidence: 91%

SAXS Study of Influence of Gemini Surfactant, 1,1'-(1,4-butanediyl)bis 3-cyclododecyloxymethylimidazolium di-chloride, on the Fully Hydrated DMPC

et al. 2010

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The study has been performed on model systems of biological membranes obtained on the basis of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and cationic gemini surfactant -derivative of 1,1 -(1,4--butane)bis 3-alkyloxymethylimidazolium chlorides with cyclic chains. The small angle X-ray scattering SAXS results implied a gradual disappearance (as a function of surfactant concentration) of the lamellar phase typical of DMPC and formation of unilamellar phase -probably a bicellar phase.

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Section: Resultssupporting

confidence: 91%

SAXS Study of Influence of Gemini Surfactant, 1,1'-(1,4-butanediyl)bis 3-cyclododecyloxymethylimidazolium di-chloride, on the Fully Hydrated DMPC

et al. 2010

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“…First, selective silylation at the primary hydroxyl groups of α-, β-, and γ-CD was carried out with tert-butyldimethylsilyl chloride (TBDMS-Cl) according to the method described by Ashton et al [37] to give silylated α-, β-, and γ-CD derivatives 1-3, respectively. Recently, it has been reported by Lesieur et al that the esterification of CD derivatives using hexanoyl chloride in the presence of 4-dimethylaminopyridine (DMAP) results in over-acylation [28] [29]. In fact, the preparation of CD palmitate under this condition leads to asymmetric CD derivatives.…”

Section: Determination Of Calcein Loading and Releasing Amountsmentioning

confidence: 99%

“…The monolayer behaviors of synthetic CD amphiphiles have been studied at the air-water interface [22]- [28]. The surface pressure-molecular area (π-A) isotherms of the monolayers disclose the size of the molecules, as well as the stability and phase behaviors of the monolayer films.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Sulfated Cyclodextrin Amphiphiles with Liposomal Encapsulation Properties

Furuike¹,

Nasu²,

Tamura³

2015

JEAS

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A novel class of amphiphiles with sulfate groups at the C-6 position and palmitoyl groups at the C-2, 3 positions of α-, β-, and γ-cyclodextrin (CD) were efficiently synthesized. These compounds formed stable monolayers with high collapse pressures at the air-water interface. The mixed monolayer behaviors of the 6-O-sulfated CD amphiphiles (SO3-CDC16) in the presence of dipalmitoyl phosphatidylcholine (DPPC) and cholesterol were discussed using the surface pressure-molecular area (π-A) isotherms. The collapse pressures showed maxima at molar ratios of SO3-CDC16 lower than 10 mol%. A morphological analysis of the liposomes containing DPPC and 4 mol% SO3-CDC16 formed in PBS was carried out using transmission electron microscopy with negative staining, and vesicles with maximum diameters of 350 -500 nm were observed. Moreover, the releasing ability of these liposomes was examined using a fluorescent compound, calcein. It was clearly shown that liposomes containing SO3-CDC16 could release encapsulated calcein more easily than liposomes consisting only of DPPC, and that the release rate depended on the phase transition temperature of the SO3-CDC16 included in the liposome membrane.

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“…This feature is being used to improve drug stability and bioavailability by increasing the drug permeability properties, solubility and/or dissolution through inclusion complexation, as well as to reduce the drug toxicity and side effects [1][2][3][4][5][6][7][8][9]. The formation of complexes between CDs and drug molecules via dynamic noncovalent interactions, in a host-guest model, has drawn considerable interest [1,[9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Bioesterified polysubstituted-cyclodextrin/surfactant nanoparticles obtained by multilevel self-assembly

Zerkoune

Angelova

Choisnard

et al. 2013

MATEC Web of Conferences

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Abstract. The purpose of this work is to investigate the inclusion complexation between a novel amphiphilic biotransesterified cyclodextrin (CD), incorporated in nanostructured environment, and a model drug compound. A water-insoluble γ-cyclodextrin derivative (γ-CD-C 10 ), polysubstituted with multiple (n=7-8) decanoyl chains (C 10 ) on the secondary face, is produced by enzymatically-assisted esterification. The γ-CD-C 10 derivative is embedded in amphiphilic nanoenvironment created by self-assembly with the lipophilic dye Nile red (NR) and the non-ionic surfactant polysorbate 80 (P80). The inclusion complexation and the environmental effects upon the γ-CD-C 10 /NR/P80 nanoparticle (NP) formation, in a multilevel self-assembly approach, are investigated by means of steady-state fluorescence and Förster resonance energy transfer (FRET) techniques. Quasi-elastic light scattering (QELS) is used to control the NP size distribution during the sequential steps of the assembling process.

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Phase behavior of fully hydrated DMPC-amphiphilic cyclodextrin systems

Cited by 52 publications

References 38 publications

SAXS Study of Influence of Gemini Surfactant, 1,1'-(1,4-butanediyl)bis 3-cyclododecyloxymethylimidazolium di-chloride, on the Fully Hydrated DMPC

SAXS Study of Influence of Gemini Surfactant, 1,1'-(1,4-butanediyl)bis 3-cyclododecyloxymethylimidazolium di-chloride, on the Fully Hydrated DMPC

Synthesis of Sulfated Cyclodextrin Amphiphiles with Liposomal Encapsulation Properties

Bioesterified polysubstituted-cyclodextrin/surfactant nanoparticles obtained by multilevel self-assembly

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