SAXS Study of Influence of Gemini Surfactant, 1,1'-(1,4-butanediyl)bis 3-cyclododecyloxymethylimidazolium di-chloride, on the Fully Hydrated DMPC

Abstract

The study has been performed on model systems of biological membranes obtained on the basis of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and cationic gemini surfactant -derivative of 1,1 -(1,4--butane)bis 3-alkyloxymethylimidazolium chlorides with cyclic chains. The small angle X-ray scattering SAXS results implied a gradual disappearance (as a function of surfactant concentration) of the lamellar phase typical of DMPC and formation of unilamellar phase -probably a bicellar phase.

The study of complexation between dicationic surfactants and the DNA duplex using structural and spectroscopic methods

“…Ten dicationic (gemini) 3,3 0 -[a,u-(dioxaalkane)] bis(1-dodecyllimidazolium)chloride surfactants (C 12 JC n , where n is the number of methylene groups in the alkyl spacer; n ¼ 2, 3, 4, 5, 6, 7, 8, 9, 10 and 12) ( Fig. 2) were synthesised and puried according to a previously described procedure [22][23][24] and were a generous gi from Dr Andrzej Skrzypczak (Poznań University of Technology, Poland). These surfactants are composed of two imidazolium rings (as the head groups) separated by a dioxaalkyl spacer group; they have identical dodecyl side chains (hydrophobic tails) and differ in the length of the spacer group [from 1,6-(2,5-dioxahexane) to 1,16-(2,15-dioxahexadecane)].…”

The severe impact of in vivo-like microfluidic flow and the influence of gemini surfactants on amyloid aggregation of hen egg white lysozyme

“…Hen egg white lysozyme was purchased from Carl Roth. All four gemini surfactants used in the study were synthesized in a way described earlier 32 and were a generous gi from Dr Andrzej Skrzypczak (Poznań University of Technology, Poland). Thio-avin T, phosphate salts and phosphoric acid used for buffer preparation and guanidinium chloride were purchased from Sigma Aldrich.…”

Structure and Conformational Dynamics of DMPC/Dicationic Surfactant and DMPC/Dicationic Surfactant/DNA Systems

“…Dicationic (gemini) surfactant 1,5-bis(1-imidazolilo-3- decyloxymethyl) pentane dichloride (IMI_oxyC5_C10) was synthesized according to the synthesis method reported by Pietralik et al [52]. Deoxyribonucleic acid of low molecular weight from salmon sperm was purchased from Sigma-Aldrich and used without further purification.…”