Pharyngeal squamous cell papilloma in adult Japanese: comparison with laryngeal papilloma in clinical manifestations and HPV infection

Abstract

A number of reports have investigated the relationship between laryngeal papilloma and human papilloma virus (HPV) infection. On the other hand, it is unclear whether the HPV infection is involved in the occurrence of pharyngeal papilloma. We hypothesized that HPV infection was involved in the occurrence of pharyngeal papilloma similarly to laryngeal papilloma. To verify this hypothesis, we investigated the presence of HPV infection. Furthermore, clinical manifestations of pharyngeal papilloma, which had rarely been reported, were discussed. A male-to-female ratio, solitary or multiple occurrences, and koilocytosis were examined in cases with pharyngeal papilloma. HPV DNA was examined with unfixed surgically resected specimens of pharyngeal papilloma. A screening test by the liquid-phase hybridization method was carried out for the HPV high-risk group (16, 18, 31, 33, 35, 39, 45, 51, 56, 58, 59, and 68) and HPV low-risk group (6, 11, 42, 43, 44). As a control, 15 cases with laryngeal papilloma for which the same screening test was carried out were employed. Pharyngeal papilloma occurred as a solitary lesion more often, whereas laryngeal papilloma occurred as multiple tumors more frequently. The HPV infection rate was 0% in pharyngeal papilloma cases, which was in stark contrast with 66.7% in the HPV low-risk group in laryngeal papilloma cases. Pharyngeal papilloma occurred as a solitary lesion in females more frequently. Contrary to our hypothesis, the involvement of HPV infection was unlikely in the occurrence of pharyngeal papilloma.

Frequent KRAS and HRAS mutations in squamous cell papillomas of the head and neck

“…The involvement of low‐risk human papillomavirus (HPV) in a subset of SCPs, particularly recurrent respiratory papillomatosis, is well known . However, the role of HPV in oral or pharyngeal SCPs appears to be limited . These findings raise the question of whether HPV involvement might be different between single and multiple papillomas, and whether anatomical site might affect the association with HPV.…”

Squamous cell papilloma of the hypopharynx with elongated villous projections

“…Few reports detail the physical findings of hypopharyngeal papillomas 1,2 . We report a case of squamous cell papilloma of the hypopharynx with elongated villous projections, a presentation not previously described.…”

“…Few reports detail the physical findings of hypopharyngeal papillomas. 1,2 We report a case of squamous cell papilloma of the hypopharynx with elongated villous projections, a presentation not previously described. Papillomas on mucosal surfaces typically appear as soft, pedunculated masses with finger-like projections.…”

Study the Role of Human Papilloma Virus and Laryngopharyngeal Reflux in Adult Vocal Fold Polyps

“…The predominance of HPV in our examination was similar to past investigations on grown-up papillomas as Makiyama et al, [25] who found that (46.1%) of patients with grown-up laryngeal papilloma were positive for HPV-6 and (7.6%) were positive for HPV-11, yet their examination included moderately more modest number of members (13 patients). Hirai et al [26] found a higher predominance of generally safe HPV (66.7%) in grownup patients with laryngeal papillomas. The way that we found the paces of event of the infection in instances of polyps approximates somewhat the paces of event in instances of grown-up papillomas, this demonstrates the presence of inactive infection in the laryngeal mucosa.…”