“…Opinions differ as to the cause of the hepatotoxicity of chloroform. Vasoconstrictive restriction of the blood flow in the liver lobules (Calvert and Brody, 1960) or toxic metabolites (Kochmann, 1923;Scholler, 1968;van Dyke, 1969) have been cited as causes. The purpose of the present study was to determine the relationship between microsomal enzymatic activity and the appearance of hepatic necrosis in rats following exposure to chloroform vapour.…”