Modification of the Effects of Chloroform on the Rat Liver

Scholler, K. L.

doi:10.1093/bja/42.7.603

Cited by 42 publications

(11 citation statements)

References 3 publications

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“…Med., Reihe A, Bd. 29, Heft 2 tetrachloride in the rat was investigated by MCLEAN and MCLEAN (1966), SEAWRIGHT and MCLEAN (1967), STENGER, MILLER and WILLIAMSON (1970), REYNOLDS, REE and MOSLEN (1972) and of chloroform by MCLEAN (1970), SCHOLLER (1970) and GOPINATH and FORD (1975). The present results show that the administration to goats of either dieldrin or phenobarbitone increased the hepatotoxicity of carbon tetrachloride and chloroform.…”

Section: Discussionmentioning

confidence: 99%

Modification of the Hepatotoxicity of Carbon Tetrachloride and Chloroform in Goats by Pre-treatment with Dieldrin and Phenobarbitone

Abdelsalam

Adam

Tartour

2010

Zentralblatt Für Veterinärmedizin Reihe A

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Summary The administration of carbon tetrachloride and chloroform to goats in which the hepatic microsomal enzyme activity had been increased by administration of dieldrin or phenobarbitone was followed by marked hepatotoxicity and rapid death. The histological and enzyme‐histochemical changes in the liver and the increase in the activity of GOT and in the concentrations of bilirubin and ammonia were evidence of the hepatotoxicity of the combined effect of the drugs. The renal lesions were accompanied by increased concentrations of urea‐nitrogen and creatinine in serum. We conclude that the induction of hepatic microsomal enzymes in goats by pre‐treatment with dieldrin or phenobarbitone increases the hepatotoxic effects of carbon tetrachloride and chloroform. Zusammenfassung Modifikation der Lebertoxizität von Tetrachlorkohlenstoff und Chloroform bei Ziegen durch Vorbehandlung mit Dieldrin und Phenobarbital Die orale Verabreichung von Tetrachlorkohlenstoff und Chloroform bei Ziegen, bei denen die mikrosomale Enzymaktivität der Leber durch Dieldrin oder Phenobarbital aktiviert worden war, wirkte akut hepatotoxisch und letal. Die histologischen und enzymhistochemischen Veränderungen in der Leber sowie der Anstieg der GOT und der Bilirubin‐ und Ammoniumkonzentrationen waren Ausdruck der Hepatotoxizität der kombinierten Wirkungen der Verbindungen. Die Nierenschädigung führte zu einer Zunahme des Harnstoff‐Stickstoffes und des Kreatinins im Serum. Es wird angenommen, daß die Induktion mikrosomaler Enzyme in der Leber durch die Vorbehandlung mit Dieldrin oder Phenobarbital die Hepatotoxizität von Tetrachlorkohlenstoff und Chloroform zu steigern vermochte. Résumé Modifikation de la toxicité hépatique du tétrachlorure de carbone et du chloroforme chez des chèvres par un prétraitement à la dieldrine et au phénobarbital L'application orale de tétrachlorure de carbone et de chloroforme chez des chèvres chez lesquelles l'activité enzymatique microsomale hépatique avait été activée par de la dieldrine et du phénobarbital provoqua une toxicité hépatique aiguë et fut létale. Les lésions histologiques et enzymo‐histochimiques dans le foie ainsi que l'augmentation de TGO, des concentrations de bilirubine et d'ammonium furent l'expression de l'hépatotoxicité des actions combinées des liaisons. Les lésions rénales ont provoqué une augmentation de l'azote de l'urée et de la créatinine dans le sérum. On a admis que l'induction des enzymes microsomiques dans le foie par un prétraitement à la dieldrine ou au phénobarbital potentialise l'hépatotoxicité du tétrachlorure de carbone et du chloroforme. Resumen Modificación de la hepatotoxicidad del tetracloruro de carbono y del cloroformo en las cabras mediante un pretratamiento con dieldrina y fenobarbitona La administración oral de tetracloruro de carbono y de cloroformo a cabras, en las cuales se había estimulado la actividad enzimática microsómica del hígado mediante dieldrina o fenobarbitona, provocaba una toxicidad hepática aguda y resultaba siendo letal. Las modificaciones histopatol...

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Section: Discussionmentioning

confidence: 99%

Modification of the Hepatotoxicity of Carbon Tetrachloride and Chloroform in Goats by Pre-treatment with Dieldrin and Phenobarbitone

Abdelsalam

Adam

Tartour

2010

Zentralblatt Für Veterinärmedizin Reihe A

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“…Part of the hepatotoxic effect of chloroform has been attributed to the synthesis of toxic metabolites by Scholler (1968), Van Dyke (1969 and McLean (1970). Induction of drugmetabolising enzymes in the liver by agents such as phenobarbitone increases susceptibility to the toxic effects of chloroform in rats (McLean; Scholler, 1970). Honjo and Netter (1969) have shown that the toxicity of chloroform in the rat can be reduced by pretreatment with the enzyme-inhibitor disulfuram.…”

Section: Discussionmentioning

confidence: 99%

Modification of the hepatotoxic effect of chloroform and halothane in calves

Gopinath

Ford

1973

The Journal of Pathology

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“…Data from these studies lend further support to the concept that reactive, toxic metabolites are generated at sites closeeto the sites of tissue injury. Studies with inhibitors of drug metabolism piperonyl butoxide (Illett et al, 1973), disulfiram (Scholler, 1970) and SKF-525A further supported the concept of bioactivation of CHCl^ by the hepatic mixed function oxidase system. Furthermore, Sipes et al (1977) showed that CHCl^* unlike CCl^, proceeded along a cytochrome P-450 dependent oxidative pathway for metabolism.…”

Section: Introductionmentioning

confidence: 88%