Pharmacovigilance of herb-drug interactions: A pharmacokinetic study on the combination administration of herbal Kang’ai injection and chemotherapy irinotecan hydrochloride injection by LC–MS/MS

Chen, Yanfei; Hu, Zhaoliang; Qi, Wen-zhu; Gao, Shuxiao; Jiang, Jing; Wang, Shixiao; Xu, Liang; Xu, Xin; Song, Min; Hang, Taijun

doi:10.1016/j.jpba.2020.113784

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Bunge) extracts. OMT is the main component of sophora ( Sophora flavescens Aiton), and our previous research indicated that it accounts for the highest proportion of the KA injection, reaching 83% (9,249 μg/mL) ( Chen Y. et al, 2021 ). The remaining 17% of the KA injection is made up of ginseng and astragalus extracts, containing 2.67 μg/mL of ginsenoside Rb1 (Rb1), 83.8 μg/mL of ginsenoside Rg1 (Rg1), 60.1 μg/mL of ginsenoside Re (Re), and 81.5 μg/mL of astragaloside IV (AS-IV) ( Chen Y. et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…OMT is the main component of sophora ( Sophora flavescens Aiton), and our previous research indicated that it accounts for the highest proportion of the KA injection, reaching 83% (9,249 μg/mL) ( Chen Y. et al, 2021 ). The remaining 17% of the KA injection is made up of ginseng and astragalus extracts, containing 2.67 μg/mL of ginsenoside Rb1 (Rb1), 83.8 μg/mL of ginsenoside Rg1 (Rg1), 60.1 μg/mL of ginsenoside Re (Re), and 81.5 μg/mL of astragaloside IV (AS-IV) ( Chen Y. et al, 2021 ). Li conducted a clinical study with 97 patients on the co-administration of the KA injection and FOLFIRI, which is composed of CPT-11 as the main component, combined with leucovorin and fluorouracil ( Li, 2014 ; Huang et al, 2019 ; National Comprehensive Cancer Network, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

“…Side effects induced by CPT-11 discussed in this study include body weight loss, hematopoietic toxicity, immune organ atrophy, and gut toxicity. Because our previous studies have shown that the KA injection does not cause pharmacokinetic changes in CPT-11 and its metabolites in rat plasma, this study only focused on the effects of CPT-11 on the pharmacokinetics of key components in the KA injection ( Chen Y. et al, 2021 ). The findings are expected to clarify the pre-clinical pharmacology and pharmacokinetic benefits and risks of the CPT-11-KA combination and provide a reference for their clinical co-administration.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of pharmacological and pharmacokinetic herb-drug interaction between irinotecan hydrochloride injection and Kangai injection in colorectal tumor-bearing mice and healthy rats

Chen,

Hu,

Jiang

et al. 2023

Front. Pharmacol.

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Introduction: Kangai (KA) injection, a Chinese herbal injection, is often used in combination with irinotecan (CPT-11) to enhance the effectiveness of anti-colorectal cancer treatment and alleviate side effects. However, the combined administration of this herb-drug pair remains controversial due to limited pre-clinical evidence and safety concerns. This study aimed to determine the pre-clinical herb-drug interactions between CPT-11 and KA injection to provide a reference for their clinical co-administration.Methods: In the pharmacological study, BALB/c mice with CT26 colorectal tumors were divided into four groups and treated with vehicle alone (0.9% saline), CPT-11 injection (100 mg/kg), KA injection (10 mL/kg), or a combination of CPT-11 and KA injection, respectively. The tumor volume of mice was monitored daily to evaluate the therapeutic effect. Daily body weight, survival rate, hematopoietic toxicity, immune organ indices, and gut toxicity were analyzed to study the adverse effects. Healthy Sprague-Dawley rats in the pharmacokinetic study were administered KA injection only (4 mL/kg), or a combination of CPT-11 injection (20 mg/kg) and KA injection, respectively. Six key components of KA injection (oxymatrine, matrine, ginsenoside Rb1, Rg1, Re, and astragaloside IV) in rat plasma samples collected within 24 h after administration were determined by LC-MS/MS.Results: The pharmacological study indicated that KA injection has the potential to enhance the anti-colorectal cancer efficacy of CPT-11 injection and alleviate the severe weight loss induced by CPT-11 injection in tumor-bearing mice. The pharmacokinetic study revealed that co-administration resulted in inhibition of oxymatrine metabolism in rats, evidenced by the significantly reduced Cmax and AUC0-t of its metabolite, matrine (p < 0.05), from 2.23 ± 0.24 to 1.38 ± 0.12 μg/mL and 8.29 ± 1.34 to 5.30 ± 0.79 μg h/mL, respectively. However, due to the similar efficacy of oxymatrine and matrine, this may not compromise the anti-cancer effect of this herb-drug pair.Discussion: This study clarified the pre-clinical pharmacology and pharmacokinetic benefits and risks of the CPT-11-KA combination and provided a reference for their clinical co-administration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of pharmacological and pharmacokinetic herb-drug interaction between irinotecan hydrochloride injection and Kangai injection in colorectal tumor-bearing mice and healthy rats

Chen,

Hu,

Jiang

et al. 2023

Front. Pharmacol.

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Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome

Dong

Chen

et al. 2023

Journal of Ethnopharmacology

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Preparation Irinotecan Hydrochloride Loaded PEGylated Liposomes Using Novel Method Supercritical Fluid and Condition Optimized by Box-Behnken Design

Mohammadi,

Karimi,

Raofie

2024

Preprint

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A semi-synthetic camptothecin derivative known as irinotecan hydrochloride is frequently used to treat colorectal cancer (CRC), including colorectal adenocarcinoma and lung cancers involving small cells. Irinotecan has a very short half-life; therefore, continuous infusions are required to keep the drug's blood levels at therapeutic levels, which could produce cumulative toxicities. Effective delivery techniques, including liposomes, have been developed to address these shortcomings. In this study, a continuous supercritical fluid approach dubbed Expansion Supercritical Fluid into an aqueous solution (ESSAS), in which the pressure decreases rapidly but remains over the critical pressure, is proposed to manufacture polyethylene glycolylated (PEGylated) liposomes carrying irinotecan hydrochloride. To accomplish this, PEGylated liposomes were created using a Box-Behnken design, and the operating parameters (flow rate, temperature, and pressure drop) were optimized. Encapsulation efficiency, mean size, and prepared liposome count were 94.6%, 55 nm, and 758 under ideal circumstances. Additionally, the stability of the PEGylated liposome was investigated during 8 weeks, and also PEGylated liposome-loaded irinotecan release profile was compared to conventional liposomes and free irinotecan, and a constant drug release was seen after the first burst release from liposomes.

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Pharmacovigilance of herb-drug interactions: A pharmacokinetic study on the combination administration of herbal Kang’ai injection and chemotherapy irinotecan hydrochloride injection by LC–MS/MS

Cited by 5 publications

References 23 publications

Evaluation of pharmacological and pharmacokinetic herb-drug interaction between irinotecan hydrochloride injection and Kangai injection in colorectal tumor-bearing mice and healthy rats

Evaluation of pharmacological and pharmacokinetic herb-drug interaction between irinotecan hydrochloride injection and Kangai injection in colorectal tumor-bearing mice and healthy rats

Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome

Preparation Irinotecan Hydrochloride Loaded PEGylated Liposomes Using Novel Method Supercritical Fluid and Condition Optimized by Box-Behnken Design

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