Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome

Dong, Bangjian; Ma, Ping; Chen, Xiaonan; Peng, Ying; Peng, Cheng; Li, Xiaobo

doi:10.1016/j.jep.2022.115871

Cited by 6 publications

(2 citation statements)

References 39 publications

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“…Guo et al (2023) used LC-IT-TOF-MS to compare the component differences between single herb and Zhi-Zi-Chi decoction (ZZCD) compounds, while the solubility of toxic substances and active components was found to affect the attenuation and synergy of the compound by quantitative characteristic compounds, laying the foundation for optimizing the compatibility of ZZCD. Dong et al (2023) used UFLC-QTRAP-MS to compare the pharmacokinetic differences between Sijunzi decoction and "quewei" Sijunzi compound (one medicinal herb was randomly removed) and found that the compatibility of the four herbs could change the pharmacokinetic properties of the compound and justify oral administration of Sijunzi decoction.…”

Section: Formula Compatibilitymentioning

confidence: 99%

Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

et al. 2023

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Natural products derived from herbal medicine are a fruitful source of lead compounds because of their structural diversity and potent bioactivities. However, despite the success of active compounds derived from herbal medicine in drug discovery, some approaches cannot effectively elucidate the overall effect and action mechanism due to their multi-component complexity. Fortunately, mass spectrometry-based metabolomics has been recognized as an effective strategy for revealing the effect and discovering active components, detailed molecular mechanisms, and multiple targets of natural products. Rapid identification of lead compounds and isolation of active components from natural products would facilitate new drug development. In this context, mass spectrometry-based metabolomics has established an integrated pharmacology framework for the discovery of bioactivity-correlated constituents, target identification, and the action mechanism of herbal medicine and natural products. High-throughput functional metabolomics techniques could be used to identify natural product structure, biological activity, efficacy mechanisms, and their mode of action on biological processes, assisting bioactive lead discovery, quality control, and accelerating discovery of novel drugs. These techniques are increasingly being developed in the era of big data and use scientific language to clarify the detailed action mechanism of herbal medicine. In this paper, the analytical characteristics and application fields of several commonly used mass spectrometers are introduced, and the application of mass spectrometry in the metabolomics of traditional Chinese medicines in recent years and its active components as well as mechanism of action are also discussed.

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Section: Formula Compatibilitymentioning

confidence: 99%

Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

et al. 2023

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“… 16 - 18 Furthermore, the pharmacokinetic properties and pharmacodynamic material foundations of SJZD have also been comprehensively elucidated. 19 SJZD is extensively employed in clinical practice for patients exhibiting vital energy deficiency, displaying satisfactory efficacy and safety, in addition, SJZD has garnered recognition for its potential in managing lung cancer by impeding tumor occurrence and progression. 20 - 23 SJZD demonstrates effectiveness in treating gastrointestinal diseases and spleen-deficiency syndrome, ameliorating gastrointestinal dysfunction, enhancing malnutrition state, and promoting performance status.…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy and Gut Microbiota Regulating-Related Effect of Si-Jun-Zi Decoction in Postoperative Non-Small Cell Lung Cancer Patients: A Prospective Observational Study

He,

Qi,

et al. 2024

Integr Cancer Ther

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Background: Postoperative non-small cell lung cancer (NSCLC) patients frequently encounter a deteriorated quality of life (QOL), disturbed immune response, and disordered homeostasis. Si-Jun-Zi Decoction (SJZD), a well-known traditional Chinese herbal formula, is frequently employed in clinical application for many years. Exploration is underway to investigate the potential therapeutic effect of SJZD for treating postoperative NSCLC. Objective: To assess the efficacy of SJZD on QOLs, hematological parameters, and regulations of gut microbiota in postoperative NSCLC patients. Methods: A prospective observational cohort study was conducted, enrolling 65 postoperative NSCLC patients between May 10, 2020 and March 15, 2021 in Yueyang Hospital, with 33 patients in SJZD group and 32 patients in control (CON) group. The SJZD group comprised of patients who received standard treatments and the SJZD decoction, while the CON group consisted of those only underwent standard treatments. The treatment period was 4 weeks. The primary outcome was QOL. The secondary outcomes involved serum immune cell and inflammation factor levels, safety, and alterations in gut microbiota. Results: SJZD group showed significant enhancements in cognitive functioning ( P = .048) at week 1 and physical functioning ( P = .019) at week 4. Lung cancer-specific symptoms included dyspnea ( P = .001), coughing ( P = .008), hemoptysis ( P = .034), peripheral neuropathy ( P = .019), and pain (arm or shoulder, P = .020, other parts, P = .019) eased significantly in the fourth week. Anemia indicators such as red blood cell count ( P = .003 at week 1, P = .029 at week 4) and hemoglobin ( P = .016 at week 1, P = .048 at week 4) were significantly elevated by SJZD. SJZD upregulated blood cell cluster differentiation (CD)3+ ( P = .001 at week 1, P < .001 at week 4), CD3+CD4+ ( P = .012 at week 1), CD3+CD8+ ( P = .027 at week 1), CD19+ ( P = .003 at week 4), increased anti-inflammatory interleukin (IL)-10 ( P = .004 at week 1, P = .003 at week 4), and decreased pro-inflammatory IL-8 ( P = .004 at week 1, p = .005 at week 4). Analysis of gut microbiota indicated that SJZD had a significant impact on increasing microbial abundance and diversity, enriching probiotic microbes, and regulating microbial biological functions. Conclusions: SJZD appears to be an effective and safe treatment for postoperative NSCLC patients. As a preliminary observational study, this study provides a foundation for further research.

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Development of modern Chinese medicine guided by molecular compatibility theory

Luo,

Zhou,

Liu

et al. 2024

Journal of Advanced Research

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Drug-polysaccharide/herb interactions and compatibility rationality of Sijunzi decoction based on comprehensive pharmacokinetic screening for multi-components in rats with spleen deficiency syndrome

Cited by 6 publications

References 39 publications

Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

Clinical Efficacy and Gut Microbiota Regulating-Related Effect of Si-Jun-Zi Decoction in Postoperative Non-Small Cell Lung Cancer Patients: A Prospective Observational Study

Development of modern Chinese medicine guided by molecular compatibility theory

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