Pharmacotherapy of Obesity: Limits and Perspectives

Rosa-Gonçalves, Pamela; Majerowicz, David

doi:10.1007/s40256-019-00328-6

Cited by 16 publications

(13 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Obesity, a metabolic disease, is becoming more common and is prone to other metabolic complications (such as cardiovascular disease and type 2 diabetes) (Sonnenburg and Backhed, 2016;Dahiya et al, 2017), pharmacotherapy causes adverse effects (Srivastava and Apovian, 2018;Rosa-Gonçalves and Majerowicz, 2019), so it is imperative to seek natural and non-toxic antiobesity substances. Lactic acid bacteria have been used in fermented dairy products for more than 100 years (Aryana and Olson, 2017) and are generally regarded as safe (GRAS) (Özogul and Hamed, 2017).…”

Section: Discussionmentioning

confidence: 99%

Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

Liu

et al. 2020

Front. Microbiol.

102

View full text Add to dashboard Cite

The global prevalence of obesity is rising year by year, which has become a public health problem worldwide. In recent years, animal studies and clinical studies have shown that some lactic acid bacteria possess an anti-obesity effect. In our previous study, mixed lactobacilli (Lactobacillus plantarum KLDS1.0344 and Lactobacillus plantarum KLDS1.0386) exhibited anti-obesity effects in vivo by significantly reducing body weight gain, Lee's index and body fat rate; however, its underlying mechanisms of action remain unclear. Therefore, the present study aims to explore the possible mechanisms for the inhibitory effect of mixed lactobacilli on obesity. C57BL/6J mice were randomly divided into three groups including control group (Control), high fat diet group (HFD) and mixed lactobacilli group (MX), and fed daily for eight consecutive weeks. The results showed that mixed lactobacilli supplementation significantly improved blood lipid levels and liver function, and alleviated liver oxidative stress. Moreover, the mixed lactobacilli supplementation significantly inhibited lipid accumulation in the liver and regulated lipid metabolism in epididymal fat pads. Notably, the mixed lactobacilli treatment modulated the gut microbiota, resulting in a significant increase in acetic acid and butyric acid. Additionally, Spearman's correlation analysis found that several specific genera were significantly correlated with obesity-related indicators. These results indicated that the mixed lactobacilli supplementation could manipulate the gut microbiota and its metabolites (acetic acid and butyric acid), resulting in reduced liver lipid accumulation and improved lipid metabolism of adipose tissue, which inhibited obesity.

show abstract

Section: Discussionmentioning

confidence: 99%

Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

Liu

et al. 2020

Front. Microbiol.

102

View full text Add to dashboard Cite

show abstract

“…Currently, most of the treatment methods are based on the appetite suppressants, inhibitors of appetite by modulating neurotransmitters in the hypothalamus. [ 2 ] However, these appetite suppressant drugs have certain side effects including cardiovascular diseases, neurological issues, and inconsistent drug effects. [ 3 ] Consumption of functional foods and nutraceuticals as dietary supplements have attracted much attention due to safe chronic application, and capacity to alleviate physiological and pathological characters of obesity through multiple mechanisms, including modulating obesity‐associated genes expression, as well as the regulation of gut microbiome and fecal metabolome.…”

Section: Introductionmentioning

confidence: 99%

Huangjinya Black Tea Alleviates Obesity and Insulin Resistance via Modulating Fecal Metabolome in High‐Fat Diet‐Fed Mice

Zhang

et al. 2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope: Huangjinya is a light-sensitive tea mutant containing low levels of tea polyphenols. Currently, most studies focused on characteristics formation, free amino acid metabolism and phytochemical purification. The biological activity of Huangjinya black tea (HJBT) on metabolic syndrome regarding fecal metabolome modulation is unavailable and is studied herein. Methods and results: High-fat diet (HFD)-fed mice are treated with HJBT for 9 weeks, various metabolic biomarkers and fecal metabolites are determined. HJBT reduces adipogenic and lipogenic gene expression, enhances lipolytic gene expression, decreases adipocyte expansion, and prevents the development of obesity. HJBT reduces lipogenic gene expression, increases fatty acid oxidation-related genes expression, which alleviates liver steatosis. HJBT enhances glucose/insulin tolerance, increases insulin/Akt signaling, attenuates hyperlipidemia and hyperglycemia, prevents the onset of insulin resistance. HJBT modulates bile acid metabolism, promotes secondary/primary bile acid ratio; increases short-chain fatty acids production, promotes saturated and polyunsaturated fatty acids content; reduces carnitines and phosphocholines, but increases myo-inositol content; decreases branched-chain and aromatic amino acids content; increases the metabolite content related to pentose phosphate pathway. Conclusion: This study reported the association between fecal metabolome modulation and metabolism improvement due to HJBT administration, proposes HJBT as a dietary intervention for preventing obesity and metabolic disorders.

show abstract

“…New compounds and new molecular targets need to be developed for the effective treatment of all obese patients in the near future. 59 As a public health problem, controlling and preventing weight gain and obesity may prevent development of related comorbidities including hypertension and renal damage in longterm.…”

Section: Resultsmentioning

confidence: 99%

Obesity and Hypertension

Ersoy

2019

Turkish Journal of Internal Medicine

View full text Add to dashboard Cite

Obesity is an important public health problem with increasing frequency, leading to different comorbidities including hypertension and can cause mortality. Possible mechanisms that increase blood pressure in overweight and obese people are renal damage, activation of the renin-angiotensin-aldosterone system, insulin resistance, hyperinsulinemia, sleep apnea syndrome, leptin-melanocortin pathway and genetic predisposition. Most of these mechanisms stimulate the sympathetic nervous system. Medical nutrition therapy, lifestyle interventions, medical and/or surgical antiobesity treatment modalities contribute to the control of blood pressure via weight loss. Besides antihypertensive medications should be chosen carefully in overweight and obese patients and drug groups preventing weight loss should not be preferred if possible.

show abstract

Pharmacotherapy of Obesity: Limits and Perspectives

Cited by 16 publications

References 124 publications

Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

Huangjinya Black Tea Alleviates Obesity and Insulin Resistance via Modulating Fecal Metabolome in High‐Fat Diet‐Fed Mice

Obesity and Hypertension

Contact Info

Product

Resources

About