Pharmacotherapy for post-traumatic stress disorder: Systematic
                        review and meta-analysis

Hoskins, Mathew; Pearce, Jennifer; Bethell, Andrew; Dankova, Liliya; Barbui, Corrado; Tol, Wietse A.; Ommeren, Mark van; Jong, Joop de; Seedat, Soraya; Chen, Hanhui; Bisson, Jonathan I.

doi:10.1192/bjp.bp.114.148551

Cited by 326 publications

(196 citation statements)

References 68 publications

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“…It is important to note that medication effects are lower than those observed in the psychological intervention [27]. Nevertheless, good evidence of ef icacy has been produced by some medications, such as paroxetine, venlafaxine, and luoxetine, at the same time most drugs lack proper proof of their ef icacy for PTSD [27]. By contrast, in one of the studies conducted by Lee et al (2016), the results indicated the small positive effect of paroxetine and luoxetine, while sertraline, venlafaxine, and nefazodone outperformed other medications [28].…”

Section: Pharmacological Interventionsmentioning

confidence: 97%

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Effectiveness of PTSD treatments for military service members and veterans

Sochenko

Gabińska

2017

PMGP

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Section: Pharmacological Interventionsmentioning

confidence: 97%

Section: Pharmacological Interventionsmentioning

confidence: 99%

Effectiveness of PTSD treatments for military service members and veterans

Sochenko

Gabińska

2017

PMGP

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“…Once and again, in the pharmacological domain, meta-analysis has shown that there is no single elective medication for a definite DSM-V disorder (such as PTSD) in spite of what the pharmaceutical industry tries to demonstrate. 44,45 Imitating pharmacological research in the domain of psychotherapy or counselling by using strict manualized procedures as if they were pills implies four erroneous assumptions are made:…”

Section: And Then Came the Manualsmentioning

confidence: 99%

Psychotherapy for torture survivors - Suggested pathways for research

Pérez–Sales¹

2017

Torture

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“…PTSD is tenacious, debilitating, and treatment refractory in many cases (Breslau, Peterson, Poisson, Schultz, & Lucia, 2004; Hoskins et al, 2015; Institute of Medicine, 2014; Kessler, 2000; Roberts, Roberts, Jones, & Bisson, 2015, 2016; Schnyder et al, 2015; Sijbrandij, Kleiboer, Bisson, Barbui, & Cuijpers, 2015). Early interventions may reduce the prevalence of chronic PTSD among survivors at risk (Kearns, Ressler, Zatzick, & Rothbaum, 2012), but they are resource demanding and effective in only a subset of survivors.…”

Section: Introductionmentioning

confidence: 99%

Application of data pooling to longitudinal studies of early post-traumatic stress disorder (PTSD): the International Consortium to Predict PTSD (ICPP) project

Ratanatharathorn

Gevonden

et al. 2018

European Journal of Psychotraumatology

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Background: Understanding the development of post-traumatic stress disorder (PTSD) is a precondition for efficient risk assessment and prevention planning. Studies to date have been site and sample specific. Towards developing generalizable models of PTSD development and prediction, the International Consortium to Predict PTSD (ICPP) compiled data from 13 longitudinal, acute-care based PTSD studies performed in six different countries.Objective: The objectives of this study were to describe the ICPP’s approach to data pooling and harmonization, and present cross-study descriptive results informing the longitudinal course of PTSD after acute trauma.Methods: Item-level data from 13 longitudinal studies of adult civilian trauma survivors were collected. Constructs (e.g. PTSD, depression), measures (questions or scales), and time variables (days from trauma) were identified and harmonized, and those with inconsistent coding (e.g. education, lifetime trauma exposure) were recoded. Administered in 11 studies, the Clinician Administered PTSD Scale (CAPS) emerged as the main measure of PTSD diagnosis and severity.Results: The pooled data set included 6254 subjects (39.9% female). Studies’ average retention rate was 87.0% (range 49.1–93.5%). Participants’ baseline assessments took place within 2 months of trauma exposure. Follow-up durations ranged from 188 to 1110 days. Reflecting studies’ inclusion criteria, the prevalence of baseline PTSD differed significantly between studies (range 3.1–61.6%), and similar differences were observed in subsequent assessments (4.3–38.2% and 3.8–27.0% for second and third assessments, respectively).Conclusion: Pooling data from independently collected studies requires careful curation of individual data sets for extracting and optimizing informative commonalities. However, it is an important step towards developing robust and generalizable prediction models for PTSD and can exceed findings of single studies. The large differences in prevalence of PTSD longitudinally cautions against using any individual study to infer trauma outcome. The multiplicity of instruments used in individual studies emphasizes the need for common data elements in future studies.

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Pharmacotherapy for post-traumatic stress disorder: Systematic review and meta-analysis

Cited by 326 publications

References 68 publications

Effectiveness of PTSD treatments for military service members and veterans

Effectiveness of PTSD treatments for military service members and veterans

Psychotherapy for torture survivors - Suggested pathways for research

Application of data pooling to longitudinal studies of early post-traumatic stress disorder (PTSD): the International Consortium to Predict PTSD (ICPP) project

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