Pharmacotherapy for Neuropathic Pain in Japan

Masuda, Ryosuke; Ajimi, Junko; Murata, Tomohiko

doi:10.1272/jnms.84.258

Cited by 13 publications

(11 citation statements)

References 8 publications

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“…Pain comes in many forms: acute, chronic, visceral, inflammatory, or neuropathic [ 1 , 2 ]. It is not simply a result of tissue damage but also reflects the influence of many psychological variables such as attention, anxiety, stress [ 3 ], suggestion, or previous experiences and may have a significant genetic contribution [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Uritu

Mihai

Stanciu

et al. 2018

Pain Research and Management

246

143

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Recently, numerous side effects of synthetic drugs have lead to using medicinal plants as a reliable source of new therapy. Pain is a global public health problem with a high impact on life quality and a huge economic implication, becoming one of the most important enemies in modern medicine. The medicinal use of plants as analgesic or antinociceptive drugs in traditional therapy is estimated to be about 80% of the world population. The Lamiaceae family, one of the most important herbal families, incorporates a wide variety of plants with biological and medical applications. In this study, the analgesic activity, possible active compounds of Lamiaceae genus, and also the possible mechanism of actions of these plants are presented. The data highlighted in this review paper provide valuable scientific information for the specific implications of Lamiaceae plants in pain modulation that might be used for isolation of potentially active compounds from some of these medicinal plants in future and formulation of commercial therapeutic agents.

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Section: Introductionmentioning

confidence: 99%

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Uritu

Mihai

Stanciu

et al. 2018

Pain Research and Management

246

143

View full text Add to dashboard Cite

show abstract

“…1 However, the pharmacotherapy of neuropathic pain remains unsatisfactory because of limited efficacy and severe adverse effects. 2 Neuropathic pain arises from a lesion or disease of the somatosensory system. 3 Functional changes in primary sensory neurons, a major origin of neuropathic pain, play a substantial role in initiation and maintenance of neuropathic pain.…”

Section: Introductionmentioning

confidence: 99%

Dorsal Root Ganglia Homeobox downregulation in primary sensory neurons contributes to neuropathic pain in rats

et al. 2020

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Transcriptional changes in primary sensory neurons are involved in initiation and maintenance of neuropathic pain. However, the transcription factors in primary sensory neurons responsible for neuropathic pain are not fully understood. Dorsal Root Ganglia Homeobox (DRGX) is a paired-like homeodomain transcription factor necessary for the development of nociceptive primary sensory neurons during the early postnatal period. However, roles for DRGX after development are largely unknown. Here, we report that DRGX downregulation in primary sensory neurons as a result of post-developmental nerve injury contributes to neuropathic pain in rats. DRGX expression was decreased in nuclei of small and medium primary sensory neurons after spinal nerve ligation. DRGX downregulation by transduction of a short hairpin RNA with an adeno-associated viral vector induced mechanical allodynia and thermal hyperalgesia. In contrast, DRGX overexpression in primary sensory neurons suppressed neuropathic pain. DRGX regulated matrix metalloproteinase-9 (MMP-9) and prostaglandin E receptor 2 mRNA expression in the DRG. MMP-9 inhibitor attenuated DRGX downregulation-induced pain. These results suggest that DRGX downregulation after development contributes to neuropathic pain through transcriptional modulation of pain-related genes in primary sensory neurons.

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“…Although recent analgesics have improved neuropathic pain therapy, pharmacotherapy for neuropathic pain remains unsatisfactory because of its low efficacy and the risk of severe adverse effects 3 . After peripheral nerve injury, primary sensory neurons become sensitized and spontaneously transmit nociceptive information to the spinal cord.…”

Section: Introductionmentioning

confidence: 99%

Increased H19 Long Non-coding RNA Expression in Schwann Cells in Peripheral Neuropathic Pain

et al. 2019

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Background: Neuropathic pain is an intractable chronic pain condition caused by damage to the somatosensory system. Although non-coding RNAs such as microRNAs are important regulators of neuropathic pain, the role of long non-coding RNAs (lncRNAs) is poorly understood. Methods: This study used a rat model of neuropathic pain induced by lumbar fifth spinal nerve ligation (SNL). Microarray analysis of lncRNAs in the lumbar fifth dorsal root ganglion was performed at day 14 after SNL. Expression levels of H19 were examined by using quantitative PCR. In situ hybridization was used to determine the distribution of H19 at day 14 after SNL. Schwann cells were isolated from peripheral nerves at day 14 after SNL. Results: H19 lncRNA was greatly increased in the L5 dorsal root ganglion at day 14 after SNL and was significantly higher at and after day 4. In the dorsal root ganglion, H19 was detected mainly in nonneuronal cells but not in primary sensory neurons. Consistent with this, H19 expression was upregulated in Schwann cells isolated from peripheral nerves after SNL. Conclusion: Increased H19 lncRNA in Schwann cells might be involved in neuropathic pain.

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Pharmacotherapy for Neuropathic Pain in Japan

Cited by 13 publications

References 8 publications

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Dorsal Root Ganglia Homeobox downregulation in primary sensory neurons contributes to neuropathic pain in rats

Increased H19 Long Non-coding RNA Expression in Schwann Cells in Peripheral Neuropathic Pain

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