Pharmacotherapy and Emerging Treatment Strategies for Schizophrenia

Sinha, Jitendra Kumar; Sachdeva, Punya; Ahmad, Faizan; Sarkar, Jasmine; Izhar, Raafiah; Rahman, Ayesha; Ghosh, Shampa

doi:10.1007/978-981-19-7022-1_10

Cited by 3 publications

(3 citation statements)

References 143 publications

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“…OBEs are hallucinatory visual experiences in which the physical body is perceived as existing in a different visual environment. These events have apparently been linked to a wide variety of psychiatric conditions, neurological issues, pharmaceutical drugs, and altered psychological states 13 . OBEs have been associated with a number of brain lesions, especially in the parietal and temporal regions, mental diseases, intense emotional states like a near‐death experience, substance abuse, migraines, and epilepsy, but relatively few have been recorded in dissociative identity disorder 14 .…”

Section: Introductionmentioning

confidence: 99%

“…These events have apparently been linked to a wide variety of psychiatric conditions, neurological issues, pharmaceutical drugs, and altered psychological states. 13 OBEs have been associated with a number of brain lesions, especially in the parietal and temporal regions, mental diseases, intense emotional states like a near‐death experience, substance abuse, migraines, and epilepsy, but relatively few have been recorded in dissociative identity disorder. 14 Ketamine has numerous names like cat valium, purple, vitamin K, cat tranquilizer, special la coke, super acid, and jet special K. One of the most common ways to administer ketamine is through nasal ingestion.…”

Section: Introductionmentioning

confidence: 99%

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Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Sachdeva

Sachdeva²,

Ghosh

et al. 2023

Ibrain

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Major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) are the most common causes of emotional distress that impair an individual's quality of life. MDD is a chronic mental illness that affects 300 million people across the world. Clinical manifestations of MDD include fatigue, loss of interest in routine tasks, psychomotor agitation, impaired ability to focus, suicidal ideation, hypersomnolence, altered psychosocial functioning, and appetite loss. Individuals with depression also demonstrate a reduced behavioral response while experiencing pleasure, a symptom known as anhedonia. Like MDD, PTSD is a prevalent and debilitating psychiatric disorder resulting from a traumatic incident such as sexual assault, war, severe accident, or natural disaster. Symptoms such as recalling event phases, hypervigilance, irritability, and anhedonia are common in PTSD. Both MDD and PTSD pose enormous socioeconomic burdens across the globe. The search for effective treatment with minimal side effects is still ongoing. Ketamine is known for its anesthetic and analgesic properties. Psychedelic and psychotropic effects of ketamine have been found on the nervous system, which highlights its toxicity. In this article, the effectiveness of ketamine as a potential therapeutic for PTSD and MDD along with its mechanisms of action, clinical trials, and possible side effects have been discussed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Sachdeva

Sachdeva²,

Ghosh

et al. 2023

Ibrain

Self Cite

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“…The results of the research of Kalinowska et al [16], Zomer et al [17], Gilbody et al [18], Ward et al [19] and Tylec et al [20] prove the validity, possibility and effectiveness of various lifestyle interventions in improving the quality of life in people with schizophrenia. Alleviating the symptoms of schizophrenia, in addition to pharmacological treatment, may also be supported by dietary components, including curcumin, stigmasterol, vitamins, exogenous melatonin and cannabidiol [21]. The Literature data also indicate that it may be beneficial to use caloric restrictions and inter alia docosahexaenoic acid, resveratrol, isoflavones and anthocyanins, which limit damage and support repair processes in DNA [22].…”

Section: Introductionmentioning

confidence: 99%

Assessing Effects of Diet Alteration on Carbohydrate–Lipid Metabolism of Antipsychotic-Treated Schizophrenia Patients in Interventional Study

Friedrich

Fugiel²,

Sadowska

2023

Nutrients

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This study aimed at finding whether healthy eating habits could be introduced to and maintained by chronically mentally ill permanent residents of a nursing home. Of interest was also if the effects of the dietary intervention would be observable as improved carbohydrate and lipid metabolism indicators were selected. Assays covered 30 antipsychotics-treated residents diagnosed with schizophrenia. The prospective method applied involved questionnaires, nutrition-related interviews, anthropometric measurements, and determination of selected biochemical parameters of the blood. The dietary intervention as well as the parallel health-promoting nutrition-related education was aimed at balancing the energy and nutrient contents. Schizophrenia patients were shown to be capable of accepting and observing the principles of appropriate nutrition. The intervention was strong enough to result in a significant blood glucose concentration drop to the reference level in all patients, regardless of the antipsychotic they were treated with. The blood lipid levels also improved, but the reduction in triacylglycerols, total cholesterol and LDL-cholesterol levels was significant in the male patients only. Nutritional changes were reflected in overweight and obese women only, in body weight reduction and in waist adipose tissue loss.

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From sleep to cancer to neurodegenerative disease: the crucial role of Hsp70 in maintaining cellular homeostasis and potential therapeutic implications

Ghosh,

Vashisth,

Ghosh

et al. 2023

Journal of Biomolecular Structure and Dynamics

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Pharmacotherapy and Emerging Treatment Strategies for Schizophrenia

Cited by 3 publications

References 143 publications

Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Assessing Effects of Diet Alteration on Carbohydrate–Lipid Metabolism of Antipsychotic-Treated Schizophrenia Patients in Interventional Study

From sleep to cancer to neurodegenerative disease: the crucial role of Hsp70 in maintaining cellular homeostasis and potential therapeutic implications

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