Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Sachdeva, Bhuvi; Sachdeva, Punya; Ghosh, Shampa; Ahmad, Faizan; Sinha, Jitendra Kumar

doi:10.1002/ibra.12094

Cited by 9 publications

(4 citation statements)

References 95 publications

(217 reference statements)

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“…While it is known that microplastics can easily enter our body (Figure 2) by the routes of ingestion, inhalation, and dermal contact, the health risks associated with each pathway are still not well understood. There is also a need for more research and development studies to find and comprehend the longstanding and enduring consequences of the exposure to microplastics on our brain as well as mental health, pre-and post-natal developmental effects, various neurological disorders like Alzheimer's disease [158], epilepsy [159], and other neuropsychological conditions [160][161][162]. While studies have shown potential risks such as inflammation, oxidative stress, and damage to organs, there is still much to be learned about the cumulative effects of exposure over time.…”

Section: Future Directionsmentioning

confidence: 99%

Microplastics as an Emerging Threat to the Global Environment and Human Health

Ghosh

Sinha²,

Ghosh³

et al. 2023

Sustainability

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In recent years, there has been mounting concern about the bearing of microplastics on human health and the comprehensive natural environment. These particles come from a variety of sources, such as soaps, personal care products, and the rundown of bigger plastic items. The impacts of microplastics on marine life and other ecosystems are substantial, including ingestion by marine animals, interference with their reproductive systems, and even death. The economic implications of microplastics are also significant, with industries, such as fishing and tourism being affected by the presence of microplastics in the environment. Exposure to microplastics can also pose potential health risks to humans, including respiratory and digestive problems, as well as disrupt sleep, contribute to obesity, and increase the risk of diabetes. To address this issue, policies and initiatives have been put in place to reduce microplastic pollution, but there are challenges that need to be overcome, such as lack of awareness, limited resources, and ineffective regulations. Further research is also needed to fully understand the impacts of microplastics on our health and to develop effective strategies to mitigate the problem. In this article, we have discussed the requirement of a multifaceted approach including reducing plastic use, promoting proper disposal and recycling of plastic waste, developing innovative technologies for capturing and removing microplastics from the environment, raising public awareness, and implementing effective regulations and policies. It is only through concerted efforts and collaboration between individuals, industries, and governments that the threat of microplastics can be tackled.

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Section: Future Directionsmentioning

confidence: 99%

Microplastics as an Emerging Threat to the Global Environment and Human Health

Ghosh

Sinha²,

Ghosh³

et al. 2023

Sustainability

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“…As the field of nanomedicine continues to advance, personalized medicine approaches are becoming increasingly feasible [34][35][36][37][38]. By tailoring nanoparticle-based therapies to the unique genetic and molecular characteristics of individual patients, the prospects for improved outcomes in CNS cancer therapy are substantial [39][40][41][42].…”

Section: The Prospects Of Personalized Nanomedicinementioning

confidence: 99%

<strong></strong>Current Status of Nanomedicine in CNS Cancer Therapeutics in the Post-COVID-19 Era

aventurato

2023

Preprint

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Central Nervous System (CNS) cancers pose a formidable challenge in the medical world, characterized by aggressive behaviors and limited therapeutic options. The emergence of nanomedicine has offered new hope in CNS cancer treatment. The COVID-19 pandemic has further accelerated the need for innovative therapeutic strategies, emphasizing the significance of nanomedicine in this era. This mini review explores the current status of nanomedicine in CNS cancer therapy, with a particular focus on the post-COVID-19 landscape. We discuss the unique challenges presented by CNS cancers, the potential of nanomedicine in overcoming these challenges, and the recent developments in the field. Additionally, we highlight the lessons learned from the pandemic and how they can be applied to improve CNS cancer therapeutics. We also shed light on the evolving regulatory landscape and the prospects of personalized nanomedicine in CNS cancer treatment. The integration of nanomedicine in CNS cancer therapy is becoming increasingly promising, and its role in the post-COVID-19 era is poised to shape the future of neuro-oncology.

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“…Brain tissues from Alzheimer's patients also contained fungal chitin [15]. AD is one of the most recurrent neurodegenerative disorders that affect a person's language acquisition, perception, memory, and thoughts [16][17][18][19][20][21][22][23][24][25], which leads to overall impaired cognition [26,27]. Additionally, those with multiple sclerosis had chitin deposition.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges

Sachdeva

Sachdeva²,

Negi

et al. 2023

Marine Drugs

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Chitin is the second most abundant biopolymer consisting of N-acetylglucosamine units and is primarily derived from the shells of marine crustaceans and the cell walls of organisms (such as bacteria, fungi, and algae). Being a biopolymer, its materialistic properties, such as biodegradability, and biocompatibility, make it a suitable choice for biomedical applications. Similarly, its deacetylated derivative, chitosan, exhibits similar biocompatibility and biodegradability properties, making it a suitable support material for biomedical applications. Furthermore, it has intrinsic material properties such as antioxidant, antibacterial, and antitumor. Population studies have projected nearly 12 million cancer patients across the globe, where most will be suffering from solid tumors. One of the shortcomings of potent anticancer drugs is finding a suitable cellular delivery material or system. Therefore, identifying new drug carriers to achieve effective anticancer therapy is becoming essential. This paper focuses on the strategies implemented using chitin and chitosan biopolymers in drug delivery for cancer treatment.

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Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

Cited by 9 publications

References 95 publications

Microplastics as an Emerging Threat to the Global Environment and Human Health

Microplastics as an Emerging Threat to the Global Environment and Human Health

<strong></strong>Current Status of Nanomedicine in CNS Cancer Therapeutics in the Post-COVID-19 Era

Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges

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