Pharmacoscintigraphic evaluation of lipid dry powder budesonide formulations for inhalation

Solid lipid microparticles as an approach to drug delivery

“…Delivery of the particles to guinea pig lungs [104] by nebulisation improved drug bioavailability and reduced dosing frequency. Sebti et al [105] compared in vivo budesonide-loaded LMs with a commercial drug product following a single inhalation in healthy volunteers. Pulmonary administration of LMs produced a significant increase in budesonide lung deposition as determined by scintigraphic evaluation of the labelled drug.…”

Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study

“…Pulmonary drug delivery system is explored as one of the alternative drug delivery systems due to higher surface area (100–140 m 2 ), high permeation of lung, avoidance of hepatic first pass metabolism, and noninvasive route for drug administration [ 5 , 6 ]. It was found to be the most efficient route for treatment of asthma, chronic obstructive pulmonary disease, and cystic fibrosis and now it is being explored for systemic administration of various categories of drug [ 7 ]. Drugs used for cancer, diabetes, and migraine could be efficiently administered by this route.…”

PROMAXX® inhaled insulin: safe and efficacious administration with a commercially available dry powder inhaler

“…Also, not other symptoms were observed suggesting of respiratory distress. That RHIIP was distributed throughout the human lung after inhalation was demonstrated in a scintigraphy study [6]. In this glucose clamp study, the PD of 3.6 mg (approximately 93 IU) radiolabelled RHIIP following inhalation from the Cyclohaler DPI was assessed and compared with that of SCIns (10 IU) [1].…”