Solid lipid microparticles as an approach to drug delivery

Abstract

LMs represent attractive and versatile carrier systems; however, their pharmaceutical applicability has been rather limited. Investigation on the use of LMs for less-established administration routes, such as pulmonary delivery, may provide further interest within the area of LM-based systems, both in industry and in the clinic.

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

“…Various methods have been used to develop solid lipid nanoparticles, including multiple emulsion, high-pressure homogenization, and ultrasonication. [82][83][84][85][86] Lipophilic bioactive compounds are highly dispersed in the lipid matrix, whereas the hydrophilic bioactive compounds are outside the lipid matrix. Dispersing the bioactive compounds in lipid involves the appropriate solvent or mechanical force.…”

In vivo Human Skin Penetration of the UV Filter Ethylhexyl Triazone: Effect of Lipid Microparticle Encapsulation

“…LMs containing EHT were prepared by the melt emulsification technique, which circumvents the use of organic solvents [23]. Several lipids (stearic acid, tristearin, and glyceryl behenate) were examined in conjunction with hydrogenated phosphatidylcholine as a biocompatible surfactant [29].…”

“…LMs, which consist of a solid hydrophobic core stabilized by a layer of surfactant molecules, were selected as a carrier for the sunscreen agent because they are based on physiologically compatible and biodegradable constituents [22, 23]. Moreover, due to their micron dimensions, LMs have the advantage of high stability and a reduced amount of surfactant required for their preparation [22, 23]. Additional advantages of LMs are a high loading capacity for lipophilic actives, such as most of the sunscreen agents, and the proper size for reduced percutaneous penetration [23].…”

“…Moreover, due to their micron dimensions, LMs have the advantage of high stability and a reduced amount of surfactant required for their preparation [22, 23]. Additional advantages of LMs are a high loading capacity for lipophilic actives, such as most of the sunscreen agents, and the proper size for reduced percutaneous penetration [23]. LMs loaded with EHT were prepared, characterized, and introduced into a model emulsion formulation and their influence on the in vivo permeation of the UV filter into human skin was investigated by tape stripping.…”

Enhancement of in vivo human skin penetration of resveratrol by chitosan-coated lipid microparticles

“…Lipid microparticles (LMs), which consist of a solid hydrophobic core stabilized by a layer of surfactant molecules, represent an appropriate carrier for topical administration since their constituents are physiologically compatible and biodegradable. Compared to liposomes and lipid nanoparticles, LMs due to their micron dimensions have the advantage of higher stability and reduced amount of potentially toxic surfactants required for their preparation [20][21][22]. Moreover, LMs exhibit high loading capacity for lipophilic substances, such as resveratrol, and their solid matrix protects the encapsulated compound against degradation [20,21].…”