Pharmacology and therapeutics in dentistry

Paracetamol overdose as a result of dental pain requiring medical treatment – two case reports

“…The drug is well absorbed from the small intestine after oral inges tion with peak plasma concentrations within 60 minutes and a half life of two hours. 5 Paracetamol is metabolised in the liver by a process called conjugation. Its mechanism of action is unclear but it is a less potent inhibitor of the cyclo oxygenase system (COX) than conven tional non-steroidal anti-infl ammatories (NSAIDS), accounting for its minimal anti-inflammatory effect.…”

Clinical evaluation of adjunctive topical therapy HCl 25 mg in surgical periodontal flap

“…11,12 Local drug tetracycline HCl 25 mg with surgical flap are very effective with removing local irritation, reducing gingival inflammation, reducing pocket depth, improves clinical attachment, can control local infection, and prevent the formation of new lesions. 15,16 The tetracycline group exhibits broad spectrum antibacterial effects including both gramnegative and aerobic and anaerobic bacteria. The tetracycline group includes antibiotics that are bacteriostatic, with low pH and anticholagenase activity can increase antibacterial ability so as to increase gingival attachment.…”

“…The tetracycline group includes antibiotics that are bacteriostatic, with low pH and anticholagenase activity can increase antibacterial ability so as to increase gingival attachment. 15,16 Tetracycline HCl 25 mg locally inserted into the periodontal pocket has been carefully studied which may stimulate serratiopeptidase enzymes and proteolytic enzymes that have antiinflammatory activity widely used in dental care. Serratiopeptidase enzymes improve microcirculation and reduce pain by blocking pain and stimulating the release of amines from inflamed tissues.…”

Uso del midazolam en el control y manejo de la ansiedad en niños durante la atención odontológica: una revisión bibliográfica

“…Los fármacos comúnmente utilizados en la sedación corresponden a la familia de las benzodiazepinas, no benzodiazepinas, opioides, barbitúricos y bloqueadores de histamina, estos medicamentos se clasifican como sedantes -hipnóticos o ansiolíticos [26][27] .…”