Pharmacologie de la nalbuphine

Arnould, J.F.; Pinaud, M.

doi:10.1016/s0750-7658(05)80018-8

Cited by 7 publications

(2 citation statements)

References 48 publications

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“…The respiratory depression induced by opioids is primarily mediated by the μ-receptor agonist activity. The μ-antagonist properties of the nalbuphine should produce fewer μ-mediated side effects such as respiratory depression, pruritus, nausea and vomiting 13,14 .…”

Section: Introductionmentioning

confidence: 99%

Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs

Frazílio

DeRossi²,

Jardim³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To measure the change in the minimum alveolar concentration of isoflurane (EtISO) associated with epidural nalbuphine and the postoperative analgesic requirements in dogs after ovariohysterectomy. METHODS:Twenty four healthy female dogs were randomly assigned to receive saline or nalbuphine at 0.3 or 0.6 mg/kg (n=8 for each group) administered via lumbosacral epidural catheter introduced cranially into the epidural canal. Changes in heart and respiratory rates and arterial blood pressure during surgery were recorded along with the corresponding EtISO. Immediately after tracheal extubation, analgesia, sedation, heart rate, respiratory rate, and arterial blood pressure were measured at predetermined intervals and every 60 min thereafter until the first rescue analgesic. RESULTS:A significant decrease in EtISO was associated with epidural nalbuphine at 0.3 mg/kg (26.3%) and 0.6 mg/kg (38.4%) but not with saline in ovariohysterectomized dogs. In the postoperative period, VAS and Colorado analgesic scores were lower for the dogs that received the higher nalbuphine dose, which only required supplemental analgesia 10 h following its administration, compared with dogs that received the lower dose. CONCLUSION:Epidural nalbuphine significantly reduces the intra-operative isoflurane requirement and provides prolonged postoperative analgesia after ovariohysterectomy in dogs.

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Section: Introductionmentioning

confidence: 99%

Effects of epidural nalbuphine on intraoperative isoflurane and postoperative analgesic requirements in dogs

Frazílio

DeRossi²,

Jardim³

et al. 2014

Acta Cir. Bras.

View full text Add to dashboard Cite

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“…Although nalbuphine is an old drug, because of its history it is not well studied, especially in relation to the dose adjustment required due to obesity [ 2 ]. It is known to have comparable water solubility to morphine [ 3 ], so we assumed that it behaves mostly like morphine (the literature is not completely in agreement about this). It is common practice not to adjust the morphine dose for body weight, as it is the lean body weight, not the total body weight, that is relevant to drug clearance.…”

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confidence: 99%