Pharmacologically active polymers, 7. Cyclophosphamide‐ and steroidhormone containing polymers as potential anticancer compounds

Abstract

A number of acrylic and methacrylic esters and N-vinyl monomers of cyclophosphamide-and testosterone derivatives were prepared. The monomers were homopolymerized and copolymerized with hydrophilic monomers to yield watersoluble products. ZUSAMMENFASSUNG:Es wurden Acryl-, Methacryl-und N-Vinyl-Derivate von Cyclophosphamid-und Testosterop-Derivaten synthetisiert. Die Monomeren wurden homopolymerisiert und mit hydrophilen Monomeren zu wasserloslichen Produkten copolymerisiert.

Perspectives in Bioactive Polymers

“…In earlier work, Donaruma and coworkers also prepared some antimalarial, polymeric sulfomes and some bioactive tropone derivatives (1,13)* Ringsdorf and coworkers have prepared many monomers, polymers and copolymers that are potentially chemotherapeutic (14,15,16). These included derivatives of cyclophosphamide which could be a potential anticancer compound (15). In addition to homopolymers, they prepared water soluble copolymers with N-vinylpyrrolidone, vinyl amine oxides and other monomers.…”

“…The polymers often showed lower toxicity levels and, in general, the dimethylolurea derivatives showed higher bacteriostatic activity than did the formaldehyde derivatives. In earlier work, Donaruma and coworkers also prepared some antimalarial, polymeric sulfomes and some bioactive tropone derivatives (1,13)* Ringsdorf and coworkers have prepared many monomers, polymers and copolymers that are potentially chemotherapeutic (14,15,16). These included derivatives of cyclophosphamide which could be a potential anticancer compound (15).…”

Structure and properties of pharmacologically active polymers

“…An important area for the potential application of pharmacologically active polymers is the development of macromolecules with carcinolytic activity [12, [33][34][35][36]. The field of polymeric antitumor agents has been reviewed recently [37].…”

Antiinflammatory polymer‐bound steroids for topical applications II. Controlled release of the steroids

“…With a view to reducing the side effects due to the repeated administration of free drugs, many attempts have been made in recent years to prolong the activity of drugs by attaching the drugs to synthetic and natural polymers. [1][2][3][4][5][6][7][8][9] A hydrolyzable bond between drug and macromolecule is required if the drug is active only in its free form. This linkage can undergo chemical and enzymatic hydrolysis with subsequent release of the drug in the body.…”