Perspectives in Bioactive Polymers

Gebelein, Charles G.; Carraher, Charles E.

doi:10.1021/bk-1982-0186.ch001

Cited by 14 publications

(3 citation statements)

References 12 publications

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“…Hassan et al synthesized new polyamides containing aromatic rings that showed remarkable antibacterial activities against a gram-positive bacterium, S. pneumoniae, and a gram-negative bacterium, P. aeruginosa [ 16 ]. So, polymeric antimicrobial agents have become a subject of intense research owing to their promising advantages over monomeric forms [ 17 , 18 ]. In view of all the properties mentioned and owing to the promising activity of this class of sulfur-containing polyamides based on the thiazole ring, this encourages us to synthesize and biologically evaluate the anticancer efficiency of a series of novel polyamides containing the thiazole moiety.…”

Section: Introductionmentioning

confidence: 99%

Biologically active sulfur-containing polyamides as promising anticancer materials

Ashour

Alqarni

Al‐Ghamdi

et al. 2023

Designed Monomers and Polymers

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Thiazol-based molecules have practically infinite biological implementation. Today, there are many medical applications for compounds containing the thiazole moiety owing to their presence in most clinically applied anticancer drugs, such as dasatinib, dabrafenib, ixabepilone, patellamide A and epothilone. In this study, the polycondensation, of a new group of thiazole-containing polyamides with the formulas PA 1–4 was carried out by the interaction of 2-aminothiazole diphenyl sulfide and variable diacid chlorides in dimethyl formamide in the presence of potassium carbonate anhydrous as a catalyst. Fourier transform-infrared spectroscopy (FTIR) was initially used to figure out the PA 1–4 structures, which were further characterized using solubility, gel permeation chromatography (GPC), X-ray diffraction analyses (XRD) and scanning electron microscopy (SEM). The solubility results revealed that the presence of heteroaromatic thiazole ring units and sulfur content in the polyamides main chain, made the solubility easier as it increases the chain packing distance. From the values of average molecular weight, it was clear that all synthesized polyamides have almost the same chain length which ranged from 37,561.80 to 39,827.66. Moreover, the thermogravimetric analysis (TGA) confirm that PA 1–4 were thermally stable even at high temperatures especially the polyamides which were synthesized from aromatic diacid chlorides. Furthermore, the newly synthesized polyamides were investigated for their antimicrobial properties against different species of Gram-positive and Gram-negative bacteria and also against different fungi. The results revealed that compound PA 2 showed the highest antibacterial activity. Also, their inhibitory activity against breast carcinoma cells (MCF-7 cell line) and colon carcinoma cells (HCT cell line) was evaluated. It was clear that there was an enhancement in the anticancer activity for the synthesized polyamides owing to the presence of the thiazole moiety as well as sulfur linkage. According to the results of the 50% inhibitory concentration (IC50), the synthesized polymers were found to be more active against the MCF-7 cell line than the HCT cell line.

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Section: Introductionmentioning

confidence: 99%

Biologically active sulfur-containing polyamides as promising anticancer materials

Ashour

Alqarni

Al‐Ghamdi

et al. 2023

Designed Monomers and Polymers

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“…Many polyindoles have been prepared to date, keeping in view the biological activity of the indole moiety, some of which display fungicidal activity . Biologically active polymers find application in various areas such as medication, weed control, insect control, etc , . Several vinyl monomers have been polymerized which exhibit potential biological activity, including 2‐vinylthiophene, 2‐vinylfuran, 2‐vinylpyrrole and N ‐vinylpyrrolidone …”

Section: Introductionmentioning

confidence: 99%

“…37 Biologically active polymers find application in various areas such as medication, weed control, insect control, etc. 38,39 Several vinyl monomers have been polymerized which exhibit potential biological activity, including 2-vinylthiophene, 40 2-vinylfuran, 41 2-vinylpyrrole 42 and N-vinylpyrrolidone. 43 Polymers are considered to be good hosting matrices for composite materials because they can easily be tailored to yield a variety of bulk physical properties as well as having long-term stability and good processability.…”

Section: Introductionmentioning

confidence: 99%

Indole‐based polymer and its silver nanocomposite as advanced antibacterial agents: synthetic path, kinetics of polymerization and applications

Srivastava

Singh

Kumar

et al. 2012

Polymer International

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Atom transfer radical polymerization of 1‐allylindole‐3‐carbaldehyde (AIC) was studied by employing 2‐bromoisobutyryl bromide as initiator in toluene. It led to controlled radical polymerization of AIC, with an increase of molecular weight along with the conversion of the monomer, and a relatively narrow molar mass distribution was obtained, as determined by gel permeation chromatography. The living nature of poly(1‐allylindole‐3‐carbaldehyde) (PAIC) was confirmed by the chain extension polymerization whereas 1H NMR analysis showed that the major population of PAIC retained the chain‐end functional group. PAIC and its silver nanocomposite were found to be biologically active against some tested bacterial pathogens. Minimum inhibitory concentration tests revealed that PAIC exhibited antibacterial activity against Staphylococcus aureus, Proteus mirabilis and Klebsiella pneumonae whereas PAIC/Ag nanocomposite showed antibacterial activity against Enterococcus faecalis and K. pneumonae. © 2012 Society of Chemical Industry

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Biologically active polymers. IV. Synthesis and antimicrobial activity of tartaric acid polyamides

Kenawy

Abdel-Hay

Shahada

et al. 2006

J of Applied Polymer Sci

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New bactericidal polyamides with quaternary ammonium or phosphonium salts were prepared, and their antimicrobial activities were explored. The polyamides were synthesized by the polycondensation of diethyl-l-tartrate or chloromethylated diethyl-l-tartrate with ethylenediamine in dry absolute ethanol. The polyamides were modified to yield polymers with either quaternary ammonium or phosphonium salts. The polymers were characterized with elemental microanalysis and 1 H-NMR and IR spectra. The antimicrobial activity of the polymers bearing onium salts was studied against Gram-negative bacteria (Escherichia coli, Pseudomones aeruginosa, Shigella sp., and Salmonella typhae), Gram-positive bacteria (Bacillus subtilis and Bacillus cereus), and a fungus (Trichophytum rubrum) by the cut-plug and viable-cell-count methods. Although all the polymers showed high antibacterial activity, some had no antifungal activity. The tributyl phosphonium salt of the polyamide was more effective against both Gram-negative and Gram-positive bacteria than the triethyl ammonium and triphenyl phosphonium salts of the polyamide.

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Perspectives in Bioactive Polymers

Cited by 14 publications

References 12 publications

Biologically active sulfur-containing polyamides as promising anticancer materials

Biologically active sulfur-containing polyamides as promising anticancer materials

Indole‐based polymer and its silver nanocomposite as advanced antibacterial agents: synthetic path, kinetics of polymerization and applications

Biologically active polymers. IV. Synthesis and antimicrobial activity of tartaric acid polyamides

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