Pharmacological treatment for Kleine-Levin syndrome

Abstract

Therapeutic trials of pharmacological treatment for Kleine-Levin syndrome with a double-blind, placebo-controlled design are needed.

Síndrome de Kleine-Levin: diagnóstico diferencial en los síndromes encefalíticos recurrentes del adolescente

“…Al menos dos episodios de hipersomnia que duran entre dos días y cinco semanas B. Los episodios recurren con una frecuencia de al menos uno cada 18 clínica y los parámetros normales del análisis del líquido cefalorraquídeo y la negatividad de las pruebas de reacción en cadena de la polimerasa para virus del herpes, junto con la falta de fiebre en todos, se sugirió una etiología autoinmune. Por ello, los tres casos recibieron terapia con corticoides y en dos de ellos se asociaron inmunoglobulinas.…”

Kleine-Levin syndrome as a neuropsychiatric presentation: A case report and review

“…There are no randomised, placebo-controlled trials of pharmacological treatment for KLS. [3] Drug trials of stimulants such as methylphenidate and amphetamine [2,8] have been suggested for symptomatic treatment during episodes of hypersomnia. Where psychotic symptoms are present, risperidone has been reported as most beneficial.…”

“…Where psychotic symptoms are present, risperidone has been reported as most beneficial. [2,3] Preventative strategies have been suggested for use in individuals who experience ≥4 episodes a year. [2,3] Lithium has been the most frequently used treatment and reported as significantly beneficial in improving abnormal behaviour and reducing the duration of episodes while decreasing relapses.…”

“…[2,3] Preventative strategies have been suggested for use in individuals who experience ≥4 episodes a year. [2,3] Lithium has been the most frequently used treatment and reported as significantly beneficial in improving abnormal behaviour and reducing the duration of episodes while decreasing relapses. [3,11] Patient A is currently largely asymptomatic on a therapeutic dose of lithium and risperidone, and only has complaints of minor memory difficulties at school.…”

“…Guided by anecdotal reports and cases documented in the literature, [2,3] he was given a trial of lithium carbonate after which his mood symptoms began to settle. A repeat SPECT of the brain showed no change to the areas of hypoperfusion.…”