Pharmacological targets and molecular mechanisms of plumbagin to treat colorectal cancer: A systematic pharmacology study

Liang, Yuanying; Zhou, Rui; Liang, Xiaoliu; Kong, Xiaolong; Yang, Bin

doi:10.1016/j.ejphar.2020.173227

Cited by 21 publications

(15 citation statements)

References 36 publications

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“…After washing with phosphate buffer saline buffer, Alexa Fluor 488‐labeled IgG (H + L) (Beyotime Biotechnology, Shanghai, China) was used as secondary antibody to incubate with the sections before the nucleolus was stained with diamidino‐2‐phenylindole solution (Beyotime Biotechnology). The positive cells were identified and determined through the approach as previously described 26,27 …”

Section: Methodsmentioning

confidence: 99%

Bioinformatics and experimental findings reveal the therapeutic actions and targets of pachymic acid against cystitis glandularis

Shi

Liang

et al. 2021

BioFactors

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Pachymic acid (PA), a bioactive ingredient isolated from Poria cocos Wolf, is reported with potential benefits of anti‐inflammatory, anti‐oxidative actions. It is reasoned that PA may play the potential benefits against cystitis glandularis (CG), an inflammation of the bladder tissue. In this study, we aimed to apply the network pharmacology and molecular docking analyses to reveal concrete anti‐CG targets and mechanisms of PA, and then the bioinformatic findings were verified by using clinical and animal samples. The methodological data from network pharmacology approach showed that 303 and 243 reporting targets of CG and PA, and other 31 shared targets of CG and PA were identified. Subsequently, all top targets of PA against CG were screened out, including cyclooxygenase‐2, epidermal growth factor receptor, tumor antigen p53 (TP53), tumor necrosis factor‐alpha (TNF), interleukin‐1 (IL‐1) beta, proto‐oncogene c‐jun. Molecular docking data demonstrated that PA exerted potent bonding capacities with TNF, TP53 proteins in CG. In human study, the findings suggested that overactivated TNF‐α expression and suppressed TP53 activation were detected in CG samples. In animal study, PA‐treated mice showed reduced intravesical IL‐1, IL‐6 levels, and lactate dehydrogenase content, downregulated TNF‐α and upregulated TP53 proteins in bladder samples. Taken together, our bioinformatics and experimental findings identify the key anti‐CG biotargets and mechanisms of PA. More markedly, these pivotal pharmacological targets of PA against CG have been screened out and verified by using computational and experimental analyses.

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Section: Methodsmentioning

confidence: 99%

Bioinformatics and experimental findings reveal the therapeutic actions and targets of pachymic acid against cystitis glandularis

Shi

Liang

et al. 2021

BioFactors

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“…As revealed by topological parameters using the Network Analyzer tool, the pivotal targets of puerarin to treat COVID-19 were identified and visualized. 22,23…”

Section: Screening Of Pivotal Targets Of Puerarin To Treat Covid-19mentioning

confidence: 99%

Anti–coronavirus disease 2019 (COVID‐19) targets and mechanisms of puerarin

Qin

Huang

et al. 2020

J Cellular Molecular Medi

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“…Applying with Cytoscape software to assay the core targets, the data of gene ontology of biological process and pathway enrichment for calycosin to treat BPA-related OS. Further, the visualization graph of drug-target-gene ontology-biological process-pathway-disease was constructed [21][22].…”

Section: Construction Of Network Visualizationmentioning

confidence: 99%

Bioinformatic Characteristics and Therapeutic Mechanisms of Calycosin-Anti-Bisphenol A-related Osteosarcoma

Tan

et al. 2020

Preprint

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BackgroundEnvironmentally, bisphenol A (BPA) is well-known as a pollutant caused human health risk, such as osteosarcoma (OS). OS, a deadly bone neoplasia, may occur in children and adults. Recently, the anti-OS pharmacotherapy prescribes limitedly. Interestingly, our previous experiments evidence that calycosin exerts the potential anti-OS action in vitro. Thus, in this report, we aimed to characterize and detail the therapeutic targets and mechanisms of calycosin-anti-BPA-related OS by means of network pharmacology and molecular docking analyses. ResultsIn details, the bioinformatic data revealed the mapped, core targets, biological functions, molecular pathways of calycosin to treat BPA-related OS. The computational analysis indicated that molecular docking ability and characteristic of core targets in calycosin to treat BPA-related OS were identified. Meanwhile, all optimal functions and pathways of calycosin-anti-BPA-related OS were revealed, as detailed in pathway networks. ConclusionsTaken together, the network pharmacology and structural biology findings illustrate the core biotargets, pharmacological functions and pathways of calycosin-anti-BPA-related OS. Potentially, these identified core targets may attribute to the scientific development of calycosin against BPA-related OS.

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Pharmacological targets and molecular mechanisms of plumbagin to treat colorectal cancer: A systematic pharmacology study

Cited by 21 publications

References 36 publications

Bioinformatics and experimental findings reveal the therapeutic actions and targets of pachymic acid against cystitis glandularis

Bioinformatics and experimental findings reveal the therapeutic actions and targets of pachymic acid against cystitis glandularis

Anti–coronavirus disease 2019 (COVID‐19) targets and mechanisms of puerarin

Bioinformatic Characteristics and Therapeutic Mechanisms of Calycosin-Anti-Bisphenol A-related Osteosarcoma

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