Bioinformatic Characteristics and Therapeutic Mechanisms of Calycosin-Anti-Bisphenol A-related Osteosarcoma

Abstract

BackgroundEnvironmentally, bisphenol A (BPA) is well-known as a pollutant caused human health risk, such as osteosarcoma (OS). OS, a deadly bone neoplasia, may occur in children and adults. Recently, the anti-OS pharmacotherapy prescribes limitedly. Interestingly, our previous experiments evidence that calycosin exerts the potential anti-OS action in vitro. Thus, in this report, we aimed to characterize and detail the therapeutic targets and mechanisms of calycosin-anti-BPA-related OS by means of network pharmacology and molecular docking analyses. ResultsIn details, the bioinformatic data revealed the mapped, core targets, biological functions, molecular pathways of calycosin to treat BPA-related OS. The computational analysis indicated that molecular docking ability and characteristic of core targets in calycosin to treat BPA-related OS were identified. Meanwhile, all optimal functions and pathways of calycosin-anti-BPA-related OS were revealed, as detailed in pathway networks. ConclusionsTaken together, the network pharmacology and structural biology findings illustrate the core biotargets, pharmacological functions and pathways of calycosin-anti-BPA-related OS. Potentially, these identified core targets may attribute to the scientific development of calycosin against BPA-related OS.

基于网络和基因差异表达信息的癌症致病基因预测

“…近年 GeneXplain [54] 研究团队 通过网络分析等方法提出了 PRKCD 和 DUSP5 是有 望治疗骨肉瘤的药物靶标. MAPK14 作为多种生化事 件的整合点被选取作为治疗骨肉瘤的核心靶点 [55] . ITGB1 是表达最高的整合素蛋白, 通常在人类恶性 肿瘤中过表达, 它可以通过 Hedgehog 信号通路, 增 强骨肉瘤的增殖和侵袭 [56] .…”