Pharmacological targeting and the diverse functions of the metastasis suppressor, NDRG1, in cancer

Park, Kyung Chan; Paluncic, Jasmina; Kovačević, Žaklina; Richardson, Des R.

doi:10.1016/j.freeradbiomed.2019.05.020

Cited by 57 publications

(69 citation statements)

References 223 publications

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“…Depending on its phosphorylation level, it is also involved in TGF-β1-induced apoptosis [60]. Moreover, NDRG1 shows different phosphorylation level in cells with active cell cycle or with blocked cell cycle [61,62]. Its phosphorylation level controls its nuclear localization and its role in cell division, DNA repair and proteasomal degradation [62].…”

Section: Protein Ontologymentioning

confidence: 99%

“…Moreover, NDRG1 shows different phosphorylation level in cells with active cell cycle or with blocked cell cycle [61,62]. Its phosphorylation level controls its nuclear localization and its role in cell division, DNA repair and proteasomal degradation [62]. Analysis of the cell cycle in A549 cells exposed to 100 µg/mL of TiO 2 -NPs for 24 h shows a mild but statistically significant reduction of the proportion of cells in the G1 phase, as compared to unexposed cells (Supplementary Figure S3).…”

Section: Protein Ontologymentioning

confidence: 99%

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Titanium Dioxide Nanoparticles Alter the Cellular Phosphoproteome in A549 Cells

et al. 2020

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TiO2 nanoparticles (NPs) are one of the most produced NPs worldwide and are used in many consumer products. Their impact on human health, especially through inhalation, has been studied for more than two decades. TiO2 is known for its strong affinity towards phosphates, and consequently interaction with cellular phosphates may be one of the mechanisms driving its toxicity. In the present study, we used a phosphoproteomics approach to document the interaction of TiO2-NP with phosphoproteins from A549 human pulmonary alveolar epithelial cells. Cells were exposed to 21 nm anatase/rutile TiO2-NPs, then their phosphopeptides were extracted and analyzed using shotgun proteomics. By comparing the phosphoprotein content, phosphorylation status and phosphorylation sites of exposed cells with that of control cells, our results show that by affecting the phosphoproteome, TiO2-NPs affect cellular processes such as apoptosis, linked with cell cycle and the DNA damage response, TP53 being central to these pathways. Other pathways including inflammation and molecular transport are also affected. These molecular mechanisms of TiO2-NP toxicity have been reported previously, our study shows for the first time that they may derive from phosphoproteome modulation, which could be one of their upstream regulators.

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Section: Protein Ontologymentioning

confidence: 99%

Section: Protein Ontologymentioning

confidence: 99%

Titanium Dioxide Nanoparticles Alter the Cellular Phosphoproteome in A549 Cells

et al. 2020

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“…HIF-1α is translocated from cytoplasm to nucleus, where it binds to HIF-1β to form HIF-1 complex. This complex works as a transcription factor, binds to hypoxia response element (HRE) in the promoter of NDRG1 [100]. Consequently, under hypoxic environment of tumor, induction of NDRG1 by HIF-1 complex is a defensive mechanism against cancer progression.…”

Section: Discussionmentioning

confidence: 99%

“…HIF-1α also removes the inhibitory effect of myc complex on this gene [100]. Furthermore, NDRG1 interferes with WNT/ β-catenin pathway by downregulating nuclear β-catenin and prevent metastasis in CRC [101].…”

Section: Component Two Contains Genes Involved In Ecm Remodeling Commentioning

confidence: 99%

Systems biomedicine of primary and metastatic colorectal cancer reveals potential therapeutic targets

Piran

Sepahi

et al. 2020

Preprint

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Colorectal cancer is one of the leading causes of cancer death worldwide. Patient survival at the time of diagnosis depends largely on the stage of the tumor. Therefore, understanding the molecular mechanisms promoting cancer progression from early stages to high-grade stages is essential for therapeutic approaches. In the present study, we conducted transcriptomic data analysis employing a systems biology method to identify potential molecular targets for colorectal cancer treatment. These targets went under investigation one by one. We proposed some genes that their expression induction or suppression alone or in combination with each other would inhibit tumor progression or metastasis based on their biological activity. They are involved in cell proliferation, energy production under hypoxic conditions, epithelial to mesenchymal transition (EMT) and angiogenesis.Employing a network analysis viewpoint, some genes were discovered that has not been reported noticeably in any kind of cancer so far. As a result, they might have some roles in progression of colorectal cancer.

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“…As a key oncogene driver in neuroblastoma, MYCN (N-Myc) is also a critical regulator of NEPC and SCLC (small cell lung cancer, a poorly differentiated neuroendocrine lung cancer) (21,37,71,115). While convincing evidence supporting a direct role of N-Myc in regulating angiogenesis is scarce, NDRG1 (N-Myc downstream-regulated gene 1) has demonstrated pleiotropic roles in angiogenesis and cancer progression, depending on cancer types (71,116).…”

Section: Mycnmentioning

confidence: 99%

Molecular Links Between Angiogenesis and Neuroendocrine Phenotypes in Prostate Cancer Progression

Wang

Zhao

et al. 2020

Front. Oncol.

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As a common therapy for prostate cancer, androgen deprivation therapy (ADT) is effective for the majority of patients. However, prolonged ADT promotes drug resistance and progression to an aggressive variant with reduced androgen receptor signaling, so called neuroendocrine prostate cancer (NEPC). Until present, NEPC is still poorly understood, and lethal with no effective treatments. Elevated expression of neuroendocrine related markers and increased angiogenesis are two prominent phenotypes of NEPC, and both of them are positively associated with cancers progression. However, direct molecular links between the two phenotypes in NEPC and their mechanisms remain largely unclear. Their elucidation should substantially expand our knowledge in NEPC. This knowledge, in turn, would facilitate the development of effective NEPC treatments. We recently showed that a single critical pathway regulates both ADT-enhanced angiogenesis and elevated expression of neuroendocrine markers. This pathway consists of CREB1, EZH2, and TSP1. Here, we seek new insights to identify molecules common to pathways promoting angiogenesis and neuroendocrine phenotypes in prostate cancer. To this end, our focus is to summarize the literature on proteins reported to regulate both neuroendocrine marker expression and angiogenesis as potential molecular links. These proteins, often described in separate biological contexts or diseases, include AURKA and AURKB,

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Pharmacological targeting and the diverse functions of the metastasis suppressor, NDRG1, in cancer

Cited by 57 publications

References 223 publications

Titanium Dioxide Nanoparticles Alter the Cellular Phosphoproteome in A549 Cells

Titanium Dioxide Nanoparticles Alter the Cellular Phosphoproteome in A549 Cells

Systems biomedicine of primary and metastatic colorectal cancer reveals potential therapeutic targets

Molecular Links Between Angiogenesis and Neuroendocrine Phenotypes in Prostate Cancer Progression

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