2020
DOI: 10.1101/2020.01.25.919415
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Systems biomedicine of primary and metastatic colorectal cancer reveals potential therapeutic targets

Abstract: Colorectal cancer is one of the leading causes of cancer death worldwide. Patient survival at the time of diagnosis depends largely on the stage of the tumor. Therefore, understanding the molecular mechanisms promoting cancer progression from early stages to high-grade stages is essential for therapeutic approaches. In the present study, we conducted transcriptomic data analysis employing a systems biology method to identify potential molecular targets for colorectal cancer treatment. These targets went under … Show more

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“…Then, a distance score, Dj, for each node in the PPI network was calculated. Dj is the average of the shortest paths from all the noncore genes to reach the node j subtracted from the average of the shortest paths from the core genes to reach the node j normalized by the average of the all shortest paths to reach the node j from the whole network (22).…”
Section: Neighbourhood Ranking To the Core Genesmentioning
confidence: 99%
“…Then, a distance score, Dj, for each node in the PPI network was calculated. Dj is the average of the shortest paths from all the noncore genes to reach the node j subtracted from the average of the shortest paths from the core genes to reach the node j normalized by the average of the all shortest paths to reach the node j from the whole network (22).…”
Section: Neighbourhood Ranking To the Core Genesmentioning
confidence: 99%