Pharmacological studies onHypericum perforatumfractions and constituents

Abstract

Thus, all tested fractions of H. perforatum exhibit a combination of Ca(2+) antagonist and phosphodiesterase-inhibition, except petroleum spirit which was devoid of later mechanism. The compounds tested showed only Ca(2+) channel blocking effect.

Antispasmodic, bronchodilator, vasorelaxant and cardiosuppressant effects of Buxus papillosa

“…Before studying the effect of drug, aortic ring was stabilized by applying tension of 2 g. After the application of PE (1 μM) and K + (80 mM), vasorelaxant effect of testing material was assessed [37]. Force-displacement transducer and Grass model 7 Polygraph were used for recording changes in isometric tension of aortic rings.…”

Roles of Chemical Complexity and Evolutionary Theory in Some Hepatic and Intestinal Enzymatic Systems in Chemical Reproducibility and Clinical Efficiency of Herbal Derivatives

“…[28, 29] or with triterpenes selected from Centella asiatica [30–32]. Then there are extracts in which this information is much less, or even extremely less, apparent as is the case with Harpagophytum procumbens [33–36], Valeriana officinalis [37–39], or Hypericum perforatum [40–42]; for these extracts it is absolutely impossible to state with certainty that the action of the preparation can be specifically attributed to harpagoside, valerenic acids, or hypericin, the molecules in which these botanical products are titrated. It is clear from the above considerations that titre standardization may be good enough to guarantee the repeatability of a clinical datum for those preparations for which there is, with some degree of certainty, a correlation between a certain titrated molecular fraction and the measurable activity of the whole preparation.…”

Secondary metabolites of sevenHypericumspecies growing in Turkey

“…Despite high evaluation and numerous published papers, Hypericum species are of high-priority research due to the increasing pharmacological significance and commercial value of Hyperici herba. In this regard, many of Hypericum species from different regions of the world (Ferraz et al 2002;Khan et al 2011;Marrelli et al 2014;Pirbalouti et al 2014) as well as from Turkish flora (Oztürk et al 2009;Uzun 2009;Toker 2009;Cirak et al 2010;Bertoli et al 2011;Cirak et al 2013) have been investigated in respect to bioactive compound accumulation. However, it should be noted that only H. perforatum has been investigated in depth throughout the world both chemically and pharmacologically and only a few studies have been undertaken on other Hypericum species although their proven pharmacological importance (Stojanovic et al 2013).…”