Pharmacological studies on ginger. II Pressor action of (6)-shogaol in anesthetized rats, or hindquarters, tail and mesenteric vascular beds of rats.

Suekawa, Mamoru; Aburada, Masaki; Hosoya, Eikichi

doi:10.1248/bpb1978.9.842

Cited by 29 publications

(7 citation statements)

References 5 publications

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“…40 The only exception is in one study of rats where decreased serum levels of PGE 2 were observed with ginger treatment. 22 The present study indicates that oral ginger could have inhibitory effects on colon tissue COX and LOX enzymes in humans.…”

Section: Discussionsupporting

confidence: 49%

Phase II Study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer

Zick

Turgeon

Vareed

et al. 2011

Cancer Prevention Research

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Inhibitors of cyclooxygenase (COX) indicate that up-regulation of inflammatory eicosanoids produced by COX, and in particular prostaglandin E2 (PGE2), are early events in the development of colorectal cancer (CRC). Ginger has demonstrated down regulation of COX in vitro and decreased incidence/ multiplicity of adenomas in rats. This study was conducted to determine if 2.0 g/day of ginger could decrease the levels of PGE2, 13-hydroxy-octadecadienoic acids (13-HODE), and 5-, 12-, & 15-hydroxyeicosatetraenoic acid (5-, 12-, & 15-HETE), in the colon mucosa of healthy volunteers. To investigate this aim we randomized 30 subjects to 2.0 g/day ginger or placebo for 28 days. Flexible sigmoidoscopy at baseline and day 28 was used to obtain colon biopsies. A liquid chromatography mass spectrometry method was used to determine eicosanoid levels in the biopsies, and levels were expressed per protein or per free arachidonic acid. There were no significant differences in mean percent change between baseline and day 28 for any of the eicosanoids, when normalized to protein. There was a significant decrease in mean percent change in PGE2 (p=0.05) and 5-HETE (p=0.04), and a trend toward significant decreases in 12-HETE (p=0.09) and 15-HETE (p=0.06) normalized to free arachidonic acid. There was no difference between the groups in terms of total adverse events (AE) (p=0.55). Based on these results, it appears that Ginger has the potential to decrease eicosanoid levels, perhaps by inhibiting their synthesis from arachidonic acid. Ginger also appeared to be tolerable and safe. Further investigation in people at high risk for CRC seems warranted.

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Section: Discussionsupporting

confidence: 49%

Phase II Study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer

Zick

Turgeon

Vareed

et al. 2011

Cancer Prevention Research

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“…In hypertensive animals, ginger has a generally dosedependent hypotensive effect, although temporary atrioventricular dissociation was documented shortly afterwards [16][17]. In addition ginger caused vasodilation in rats and rabbits, following induced vasoconstriction, and exhibited calcium channel-blocking activity similar to verapamil [16].…”

Section: Hypotensive Effectmentioning

confidence: 99%

Ginger (Zingiber officinale Roscoe): A hot remedy for cardiovascular disease?

Nicoll

Henein

2009

International Journal of Cardiology

157

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“…On the contrary, in vivo studies, using different forms of ginger (raw, cooked, or dried) do not show an effect on bleeding time, platelet aggregation or thromboxane production [110 -112] . Certain ginger components, including shogaol and gingerol, have been studied for positive inotropic and pressor effects [113,114] ; however, no clinical trials currently support these effects.…”

Section: Pharmacologymentioning

confidence: 99%