Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. &amp; Perr. leaves

Idakwoji, Precious A.; Atanu, Francis O.; Nweje-Anyalowu, Paul C.; Momoh, Theophilus Boniface; Oniwon, Wisdom O.; Elazab, Sara T.; Sharkawi, Souty M.Z.; Waheed, Rania M.; Youssef, A.-B.M.; Batiha, Gaber El‐Saber

doi:10.56499/jppres21.1265_10.3.459

Cited by 2 publications

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Pregnancy and COVID-19: high or low risk of vertical transmission

et al. 2022

Self Cite

View full text Add to dashboard Cite

Coronavirus disease 19 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Throughout the pandemic, evidence on the effects of COVID-19 during pregnancy has been inadequate due to the limited number of studies published. Therefore, the objective of this systematic review was to evaluate current literature regarding the effects of COVID-19 during pregnancy and establish pregnancy outcomes and vertical and perinatal transmission during pregnancy. Multiple databases were searched, including Embase, Medline, Web of Science, Scopus, and Cochrane Central Register of Control Clinical Trials, using the following keywords: [Pregnancy] AND [COVID-19 OR SARS-CoV-2 OR nCoV-19] OR [Perinatal transmission, Vertical transmission (VT), Pregnancy complications], [Pregnancy] AND [Hyperinflammation OR Cytokine storm]. We excluded in vitro and experimental studies, but also ex-vivo and animal study methods. To exclude the risk of bias during data collection and interpretation, all included studies were peer-reviewed publications. This review is estimated to tabulate the study intervention characteristics and compare them against the planned groups for each synthesis. Our findings showed that pregnant women are commonly susceptible to respiratory viral infections and severe pneumonia due to physiological immune suppression and pregnancy-induced changes. VT of SARS-CoV-2 infection during pregnancy is associated with a great deal of controversy and conflict. However, there is still no robust clinical evidence of VT. Furthermore, the clinical presentation and management of COVID-19 during pregnancy are nearly identical to those of non-pregnant women. Finally, chloroquine and remdesivir are the only two drugs evaluated as adequate for the management of COVID-19 during pregnancy.

show abstract

Pregnancy and COVID-19: high or low risk of vertical transmission

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Molecular Docking Studies of 3-diazo-1-methyl-1,3-dihydro-indol-2-one from Anogeissus leiocarpus leaves against some Inflammatory Mediators

Idakwoji,

Udoeyop,

Okorie

et al. 2024

Preprint

View full text Add to dashboard Cite

Targeting key proteins in inflammatory pathways can be an effective strategy for developing new anti-inflammatory therapies. This study focused on molecular docking of 3-diazo-1-methyl-1, 3-dihydro-indol-2-one against key molecular targets such as cyclooxygenase 2 (COX-2), prostaglandin E2 (PDE) synthase, tumor necrosis factor (TNF-α), interleukin 1 beta (IL-1β) and N-methyl-D-Aspartate (NMDA) receptor. 3D Structures of COX-2 (PDB ID: 5IKR), NMDA receptor (PDB ID: 5EWJ), PGE-Synthase (PDB ID: 4AL1), TNF-α (PDB ID: 5MU8), and IL-1β (PDB ID: 4G6J) were obtained from protein databank. The 3D format of 3-diazo-1-methyl-1, 3-dihydro-indol-2-one and standard anti-inflammatory drug were downloaded from PubChem database in SDF file. Molecular docking was performed using AutoDock Vina Software. The 2D diagrams and the 3D (surface) views of the protein-ligand interactions renderings were done using Discovery studio software and Pymol software respectively. The Physicochemical, lipophilicity, solubility, pharmacokinetics and Lipinski drug-likeness of the compound and standard drug were determined using SwissADME Server. The docking results revealed that 3-diazo-1-methyl-1, 3-dihydro-indol-2-one exhibited strong binding affinity towards COX-2 (-7.2 kcal/mol). ADME-T analysis revealed that the compound possess favorable ADMET profiles indicating good oral bioavailability, metabolic stability and low toxicity. It was concluded that 3-diazo-1-methyl-1, 3-dihydro-indol-2-one could be a useful candidate for further development into an anti-inflammatory drug.

show abstract

Pharmacological studies of anti-inflammatory, anti-nociceptive and anti-pyretic compounds found in chromatographic fractions of Anogeissus leiocarpa (DC). Guill. & Perr. leaves

Cited by 2 publications

References 17 publications

Pregnancy and COVID-19: high or low risk of vertical transmission

Pregnancy and COVID-19: high or low risk of vertical transmission

Molecular Docking Studies of 3-diazo-1-methyl-1,3-dihydro-indol-2-one from Anogeissus leiocarpus leaves against some Inflammatory Mediators

Contact Info

Product

Resources

About