Molecular Docking Studies of 3-diazo-1-methyl-1,3-dihydro-indol-2-one from Anogeissus leiocarpus leaves against some Inflammatory Mediators
Precious A. Idakwoji,
Favor A. Udoeyop,
Claribel C. Okorie
et al.
Abstract:Targeting key proteins in inflammatory pathways can be an effective strategy for developing new anti-inflammatory therapies. This study focused on molecular docking of 3-diazo-1-methyl-1, 3-dihydro-indol-2-one against key molecular targets such as cyclooxygenase 2 (COX-2), prostaglandin E2 (PDE) synthase, tumor necrosis factor (TNF-α), interleukin 1 beta (IL-1β) and N-methyl-D-Aspartate (NMDA) receptor. 3D Structures of COX-2 (PDB ID: 5IKR), NMDA receptor (PDB ID: 5EWJ), PGE-Synthase (PDB ID: 4AL1), TNF-α (PDB… Show more
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