Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-l-carnitine

Coleman, John K.M.; Kopke, Richard D.; Liu, J.; Ge, Xianxi; Harper, Elizabeth A.; Jones, Gavin E. G.; Cater, T.L.; Jackson, Ronald L.

doi:10.1016/j.heares.2006.08.008

Cited by 82 publications

(57 citation statements)

References 37 publications

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“…This leads to the assumption that the combination of different antioxidants might have a synergistic effect, a point that has been made previously in the case of stroke [225] and trauma-induced hearing loss [255] and supports the idea of using plant derived products, which contain a multitude of different molecules, as sources of antioxidants [256,257].…”

Section: Future Directionssupporting

confidence: 62%

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

121

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Abstract:Reactive oxygen species (ROS) are widely believed to cause or aggravate several human pathologies such as neurodegenerative diseases, cancer, stroke and many other ailments. Antioxidants are assumed to counteract the harmful effects of ROS and therefore prevent or treat oxidative stress-related diseases. In this report, recent human studies exploring the efficiency of antioxidants in prevention and treatment of various diseases are reviewed. Few antioxidants including edaravone (for ischemic stroke in Japan), Nacetylcysteine (for acetaminophen toxicity), alfa-lipoic acid (for diabetic neuropathy) and some flavonoids (polyphenolic compounds present in dietary plants), such as micronized purified flavonoid fraction (diosmin and hesperidin) and oxerutins (for chronic venous insufficiency) as well as baicalein and catechins (for osteoarthritis) have found accepted clinical use. However, despite much enthusiasm in the 1980s and 1990s, many well-known agents such as antioxidant vitamins and also more recently developed compounds such as nitrones have not successfully passed the scrutiny of clinical trials for prevention and treatment of various diseases. This has given rise to a pessimistic view of antioxidant therapy, however, the evidence from human epidemiological studies about the beneficial effects of dietary antioxidants and preclinical in vitro and animal data are compelling. We have probably wasted too much time on agents like antioxidant vitamins instead of focusing on more disease specific, target-directed, highly bioavailable antioxidants. We here discuss possible reasons for the lack of success in some clinical trials and seek to provide some suggestions to be considered if antioxidant therapy is to succeed as an effective therapeutic strategy.

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Section: Future Directionssupporting

confidence: 62%

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

121

View full text Add to dashboard Cite

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“…Consistent with the functional protection, the treatment significantly rescued 40-50% of OHCs from AAT. These results are consistent with previous reports using the same noise level and duration [21,28,29,31,54] although the results in the present study were obtained 10 days, instead of 21 days, after noise exposure. The ABR threshold shifts in the present study were higher than those recorded at 21 days after noise by 12-15 dB, which may represent residual temporary threshold shift.…”

Section: Discussionsupporting

confidence: 94%

Gene Therapy for Hearing Protection

Lee¹

2017

Korean J Otorhinolaryngol-Head Neck Surg

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Objective. Inhibition of inflammation and free radical formation in the cochlea may be involved in antioxidant treatment in acute acoustic trauma. Procedure. Chinchilla were exposed to 105 dB sound pressure level octave band noise for 6 hours. One group of chinchilla was treated with antioxidants after noise exposure. Auditory brainstem responses, outer hair cell counts, and immunohistochemical analyses of biomarkers in the cochlea were conducted. Results. The antioxidant treatment significantly reduced hearing threshold shifts, outer hair cell loss, numbers of CD45 + cells, as well as 4-hydroxy-2-nonenal and nitrotyrosine formation in the cochlea. Conclusion. Antioxidant treatment may provide protection to sensory cells by inhibiting formation of reactive oxygen and nitrogen products and migration of mononuclear phagocytes in the cochlea. The present study provides further evidence of effectiveness of antioxidant treatment in reducing permanent hearing loss.

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“…For inner ear disorders, glucocorticoids are typically administered systemically. Unfortunately, corticosteroids are associated with some serious side effects, including psychosis, gastritis, hypertension, insulin resistance, sleep disturbances, and aseptic necrosis of the hip [Coleman et al, 2007].…”

Section: Discussionmentioning

confidence: 99%

Primary Observation of Early Transtympanic Steroid Injection in Patients with Delayed Treatment of Noise-Induced Hearing Loss

Zhou

Zheng

et al. 2013

Audiol Neurotol

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Approximately 5% of the population worldwide suffer from varieties of noise-induced hearing loss (NIHL). Prevention and early identification remain the best methods of approaching NIHL. Over the years, numerous methods of improving the outcome in patients presenting with NIHL have been evaluated; however, these are far from sufficient. The present trial aimed to evaluate the effectiveness of early transtympanic steroid injection in patients with delayed treatment of NIHL. Because systemic steroid treatment is the most common treatment of choice in the management of NIHL, it was considered unethical to replace the first-line systemic steroid treatment with transtympanic treatment. Therefore, the present study evaluated the combination of conventional steroid treatment with a transtympanic steroid injection. A total of 53 patients diagnosed with delayed treatment of NIHL were randomized into a transtympanic group (TR group, n = 27) and a control group (n = 26). The TR group received the conventional steroid treatment plus four courses of additional transtympanic injections of methylprednisolone 3 days after NIHL onset, and the control group received the conventional steroid treatment. Transtympanic injection was performed through laser-assisted myringotomy (a 0.5- to 1-mm perforation was made in the tympanic membrane) under an operation microscope. A total of 51.9% of the patients in the TR group had a ≥15-dB HL improvement in pure-tone average, compared with 23.1% of the patients in the control group, at the 8-week follow-up audiogram. A total of 66.7% of the patients in the TR group had an improvement of ≥15% in the speech discrimination score, compared with 30.8% of patients in the control group, 8 weeks after the treatment. The differences between the two groups were statistically significant. The outcome of this trial indicates that delayed treatment of NIHL may be preferable if transtympanic therapy can be applied earlier. The large variability in the individual results indicates that additional carefully controlled studies with larger sample sizes are needed to understand the effect of early transtympanic therapy in patients with delayed treatment of NIHL.

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Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-l-carnitine

Cited by 82 publications

References 37 publications

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Gene Therapy for Hearing Protection

Primary Observation of Early Transtympanic Steroid Injection in Patients with Delayed Treatment of Noise-Induced Hearing Loss

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