Pharmacological Prophylaxis and Management of Adult Postoperative/Postdischarge Nausea and Vomiting

The Effects of Stimulation of Acupressure Point P6 on Postoperative Nausea and Vomiting: A Review of Literature

“…Scopolamine suppresses the noradrenergic system, resulting in decreased response and improved adaptation to vestibular stimulation. 16 According to a quantitative systematic review of 23 reports, transdermal scopolamine (TDS) application resulted in a reduction of PONV (RR a 0.66; 95% CI b , 0.57-0.76). 24 Jones et al, 26 using a randomized, doubleblind, placebo-controlled, prospective study, compared the effect of TDS and a placebo on incidence and severity of PONV.…”

Postoperative Nausea and Vomiting in Adults: Implications for Critical Care

“…Postejection appears to be the diminished sensation of nausea in the central nervous system. [9][10][11] Nausea is a symptom associated with vomiting. Because it is a subjective sensation, nausea is considered conscious cortical activity.…”

Current research on PONV/PDNV: Practical implications for today’s pharmacist

“…6 Therefore, rescue medications during the immediate postoperative period should be limited to drugs that have different mechanisms of action. 13 For example, if ondansetron is administered for prophylaxis but PONV occurs, then promethazine or diphenhydramine could be given for rescue treatment rather than a repeat dose of ondansetron. 14 Other factors to consider when managing PONV and PDNV include the pharmacologic differences among 5-HT 3 antagonists, as molecular distinctions between the members of drug class may impact outcomes for patients.…”