Pharmacological Properties of Scoparia Dulcis: A Review

Murti, Krishna; Panchal, Mayank; Taya, Poonam; Singh, Raghuveer

doi:10.5567/pharmacologia.2012.344.347

Cited by 24 publications

(26 citation statements)

References 15 publications

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“…Valerian is a popular herbal product often used to treat insomnia, anxiety and related ailments (Murti et al, 2011). Valerian root extracts contain essential oils rich in sesquiterpenes such as valerenic acid and its derivatives.…”

Section: Introductionmentioning

confidence: 99%

“…The mature plant is about 50-150 cm tall with pinnate leaves and the stem is upright and without branches (Fleming, 1998). Valerian fresh root has no odour, while the dried root possesses distinctly unpleasant smell similar to old dirty socks (Schulz et al, 1998).Valerian is a popular herbal product often used to treat insomnia, anxiety and related ailments (Murti et al, 2011). Valerian root extracts contain essential oils rich in sesquiterpenes such as valerenic acid and its derivatives.…”

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confidence: 99%

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Chemical analysis and biological potential of <i>Valerian root</i> as used by herbal practitioners in the Eastern Cape Province, South Africa

Dyayiya¹,

Oyemitan²,

Matewu³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: Herbal practitioners in the Eastern Cape of South Africa use valerian root (Valeriana capensis, Valerianaceae) to manage pains, arthritis and inflammation. The herb prepared from this plant was studied to determine the chemical composition of its essential oil, carried out phytochemical screening and biological activities on its infusion extract as used by the herbal practitioner. Materials and Methods: Essential oil of Valerian root was obtained by hydrodistillation and subjected to chemical analyses. Infusion extract of the Valerian root was screened to determine its secondary metabolites and the relative abundance of some major metabolites. The infusion extract was further evaluated for acute toxicity (LD50), anti-inflammatory and analgesic activities in rodents. Results: The yield of the essential oil was 0.18% w/w. The GC/MS analysis indicated the presence of 42 compounds with major ones being caryophyllene oxide (18.11%), viridiflorol (9.37%) and bornyl acetate (8.84%). Phytochemicals found in the infusion extract were alkaloids, saponins, tannins and flavonoids while quantitative screenings showed saponins and flavonoids accounted for 6.39% and 7.40% respectively. The LD50 of the extract was found to be 3808 mg/kg per oral. The infusion extract of the root (250-500 mg/kg, p.o.) caused significant (p<0.01) activity in the carrageenan-induced rat paw oedema model comparable to aspirin, indicating anti-inflammatory activity; but lacked analgesic activity on the acetic acid-induced writhing test. Conclusion:The infusion extract possessed significant anti-inflammatory but lacked analgesic activity; the present data justify the use of this herbal agent by the herbal practitioners from the Eastern Cape region of South Africa. Key words:Valeriana capensis, essential oil, caryophyllene oxide, infusion extract, anti-inflammatory, analgesic IntroductionMedicinal plants have been in use for centuries in South Africa, especially in the rural communities throughout the Eastern Cape Province where many people consult traditional healers who use medicinal plants as major sources of their medication (Cocks and Moller, 2002). Valerian root (Family: Valerianaceae) is a perennial flowering plant with over 350 species and several more subspecies (Bardakci et al., 2012). Valerian is native to Europe and Asia, although it has been naturalized in Eastern North America and other parts of the world including South Africa (Van Wyk et al., 1997). The part of the plant used medicinally is the root or rhizome which is light grayish brown, about the size of a finger joint, bearing many rootlets. The mature plant is about 50-150 cm tall with pinnate leaves and the stem is upright and without branches (Fleming, 1998). Valerian fresh root has no odour, while the dried root possesses distinctly unpleasant smell similar to old dirty socks (Schulz et al., 1998).Valerian is a popular herbal product often used to treat insomnia, anxiety and related ailments (Murti et al., 2011). Valerian root extracts contain essential oils...

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Chemical analysis and biological potential of <i>Valerian root</i> as used by herbal practitioners in the Eastern Cape Province, South Africa

Dyayiya¹,

Oyemitan²,

Matewu³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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“…This plant is a native to Europe and Asia and has naturalized in eastern North America, which mainly grows in the northern temperate and cold regions (Abdi 2012, Zebarjadi et al 2011, Murti et al 2011. Valerian contains over 150 chemical constituents; many of them are physiologically active (Patocka and Jakl 2010).…”

Section: Introductionmentioning

confidence: 99%

Rapid in vitro shoot regeneration of Valeriana officinalis

Tansaz

Zamani

Otroshy

2015

Plant Tissue Cult. & Biotech.

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A protocol for efficient and rapid regeneration of medicinal plant (Valeriana officinalis L.) was developed by in vitro culture of crown division. The effect of three different culture media, MS, B5 and MB (a new combined medium) containing 12 combinations of BAP and NAA was evaluated on regeneration and growth parameters. Results revealed a significant response of media used for shoot regeneration. The best frequency of regenerated plantlets (80%) and number of regenerated shoots (9.43) were obtained on MB containing BAP (0.5 mg/l) + (0.25 mg/l). The maximum length of shoots was found in the MB with BAP (1 mg/l) + (0.5 mg/l). A positive influence of time was noticed on rooting of regenerated shoots. All acclimatized plantletswere successfully established in a greenhouse and showed normal growth. This protocol provides a technique for mass propagation of valerian and helpful for future genetic improvement studies.

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“…Valeriana officinalis is a hardy perennial flowering plant 12 . It is native to Europe and parts of Asia and has been naturalized in North America for commercial use.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of single dose antihistamine vs. single dose valerian-hops in subjective sleep measures among war refugees: a comparison trial

Gammoh

Al-Smadi

Mukattash

et al. 2017

Arch. Clin. Psychiatry (São Paulo)

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Background: Many sedatives and anxiolytics are used in single dose or chronically to aid sleep. Clinically important sedatives include valerian-hops and antihistamines as they are used over the counter and are highly accessible and safe agents. Objectives: To evaluate and compare a single dose of chlorpheniramine versus valerian-hops combination in modulating subjective sleep measures in insomniac war refugees. Methods: Insomnia among refugees was screened using the Insomnia Severity Index (ISI). Insomniac subjects were randomized to received a single dose valerian-hops (320/80 mg) (n = 65), or chlorpheneramine (4 mg) (n = 50) or placebo (n = 76) two hours prior sleeping. Participants were instructed to complete Leeds Sleep Evaluation Questionnaire (LSEQ), visual analogue scales of anxiety and sedation. Also sleep latency, total hours slept and self-rated improvement were obtained. Results: Almost 75% of screened refugees had insomnia. Chlorpheneramine reduced sleep latency and anxiety significantly, however it resulted in poor sleep quality. Valerian-hops group showed marked anxiolysis one hour after dosing, a sleep quality similar to placebo and better than chlorpheneramine, and better alertness compared to placebo. Participants satisfaction was higher with chlorpheneramine and there was no difference in the total hours slept. Discussion: Valerian-hops combination may provide better sleep quality than antihistamines.

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Pharmacological Properties of Scoparia Dulcis: A Review

Cited by 24 publications

References 15 publications

Chemical analysis and biological potential of <i>Valerian root</i> as used by herbal practitioners in the Eastern Cape Province, South Africa

Chemical analysis and biological potential of <i>Valerian root</i> as used by herbal practitioners in the Eastern Cape Province, South Africa

Rapid in vitro shoot regeneration of Valeriana officinalis

Efficacy of single dose antihistamine vs. single dose valerian-hops in subjective sleep measures among war refugees: a comparison trial

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