Pharmacological properties of mangiferin: bioavailability, mechanisms of action and clinical perspectives

Zivković, Jelena; Kumar, Kammala Ananth; Rushendran, Rapuru; Ilango, Kaliappan; Fahmy, Nouran M.; El-Nashar, Heba A. S.; El-Shazly, Mohamed; Ezzat, Shahira M.; Melgar-Lalanne, Guiomar; Romero-Montero, Alejandra; Peña-Corona, Sheila I.; Leyva-Gomez, Gerardo; Sharifi-Rad, Javad; Calina, Daniela

doi:10.1007/s00210-023-02682-4

Cited by 6 publications

(6 citation statements)

References 105 publications

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“…Overall, the wound-healing capabilities of SMPE compared with standard mangiferin were proven through mechanisms involving fibroblast proliferation and migration. Our results confirmed the previous pharmacological activity evaluations of mangiferin and mango peel extract for wound healing and the treatment of skin diseases [10,12,26,27]. Moreover, SMPE exhibited nontoxic effects across the tested concentrations (0.25-10 µg/mL) and contributed to fibroblast proliferation at the optimal concentration of 1 µg/mL.…”

Section: Bioactivities Of Standardized Mangiferin-rich Manaifera Indi...supporting

confidence: 90%

“…Mangiferin and its derivatives have exhibited a wide range of pharmacological activities, especially antioxidant effects. They have also shown potential for anticancer, antimicrobial, antiatherosclerotic, antiallergenic, antidiarrhea, anti-inflammatory, analgesic, hepatoprotective, immunomodulatory, hypolipidemic, antiobesity, and antidiabetic activities [7][8][9][10]. Mangiferin is also utilized as an active ingredient in cosmeceutical products, including sunscreen.…”

Section: Introductionmentioning

confidence: 99%

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Box–Behnken Design to Optimize Standardized Mangiferin-Rich Mango Peel Extract from Agro-Industrial Waste Product

Sumpavapol,

Waehayee,

Suklim

et al. 2023

Sustainability

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The light mango or “Ma-Muang Bao” (Mangifere indica L. var.) is a native mango species originating from Malaysia and southern Thailand. The whole Ma-Muang Bao fruit, except peels, is popular as both a raw and ripe fruit for consumption, as well as being used in various processed food products. This study aims to transform the peel of a specific mango variety, which is a byproduct of the agro-industrial sweet, pickled mangoes industry, into a valuable bioactive ingredient for healthcare products. This is achieved through the establishment of a standardized mangiferin-rich mango peel extract (SMPE). Employing the Box–Behnken design (BBD) within the framework of response surface methodology (RSM), an optimal microwave-assisted extraction procedure was developed. A total of 27 experiments, each with four independent variables, including solvent ratio, extraction power, extraction time, and ethanol (EtOH) ratio, were conducted to optimize the extraction method in terms of mangiferin content and extraction yield. The optimized extraction conditions encompassed a solvent ratio of 120 mL EtOH/100 g sample, an extraction power of 450 W, an extraction time of approximately 4.3 min, and an EtOH ratio of 69.44% (EtOH in water). Small-scale extractions were carried out using the following specified parameters: solvent ratio of 120 mL, extraction power of 450 W, extraction time of 4 min, and EtOH ratio of 70% EtOH. These extractions yielded an extract with a mangiferin content of 27.24 ± 2.05 mg/g and an extraction yield of 3.71 ± 0.17% w/w. Notably, these outcomes were better from the mangiferin content of 19.62 mg/g and a yield of fresh peel of 5.61% estimated through BBD analysis. Furthermore, a pilot-scale extraction was performed using 7 kg of fresh mango peel and 70% EtOH (8.4 L) for 4 min, resulting in an extract with a mangiferin content of 51.85 ± 0.35 mg/g and a fresh peel yield of 4.35% w/w. This method emerges as the most suitable for mango peel extraction and forms the basis of the SMPE. The results from biological activities highlight the potential use of SMPE as the active ingredient for cosmeceutical or healthcare products for wound-healing and skin-brightening agents. Additionally, the knowledge from this study presents an alternative approach to various plant sources and sustainable extraction methods for the herbal extract industry.

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Section: Bioactivities Of Standardized Mangiferin-rich Manaifera Indi...supporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Box–Behnken Design to Optimize Standardized Mangiferin-Rich Mango Peel Extract from Agro-Industrial Waste Product

Sumpavapol,

Waehayee,

Suklim

et al. 2023

Sustainability

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“…39,40 Especially, some studies revealed the enormous potential of MF to regulate and improve various metabolic disorders such as hyperlipidemia and hyperglycemia. 41,42 In terms of these pharmacological activities, MF appears to be a potential candidate for treating diabetic wound, which has been verified by a previous study aimed at discerning the role of MF in the process of wound healing in DM. 43 However, clinical application is restricted owing to its poor hydrosolubility (0.111 mg•mL −1 ) and low bioavailability.…”

Section: Introductionmentioning

confidence: 57%

“…Mangiferin (MF), a natural polyphenol of C-glucoside xanthone (Scheme ), is originally isolated from Mangifera indica L. (Anacardiaceae) and commonly found in at least 16 plant families. , Due to the various positive health benefits, including anti-inflammatory, antioxidant, antiapoptotic, anticancer and antivirus functions, MF has received considerable attention in medical and nutritional research. , Especially, some studies revealed the enormous potential of MF to regulate and improve various metabolic disorders such as hyperlipidemia and hyperglycemia. , In terms of these pharmacological activities, MF appears to be a potential candidate for treating diabetic wound, which has been verified by a previous study aimed at discerning the role of MF in the process of wound healing in DM . However, clinical application is restricted owing to its poor hydrosolubility (0.111 mg·mL –1 ) and low bioavailability.…”

Section: Introductionmentioning

confidence: 99%

A Multifunctional Hydrogel Fabricated by Direct Self-Assembly of Natural Herbal Small Molecule Mangiferin for Treating Diabetic Wounds

Hao,

Wei,

et al. 2024

ACS Appl. Mater. Interfaces

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Clinical studies have continually referred to the involvement of drug carrier having dramatic negative influences on the biocompatibility, biodegradability, and loading efficacy of hydrogel. To overcome this deficiency, researchers have proposed to directly self-assemble natural herbal small molecules into a hydrogel without any structural modification. However, it is still a formidable challenge due to the high requirements on the structure of natural molecules, leading to a rarity of this type of hydrogel. Mangiferin (MF) is a natural polyphenol of C-glucoside xanthone with various positive health benefits, including the treatment of diabetic wounds, but its poor hydrosolubility and low bioavailability significantly restrict the clinical application. Inspired by these, with heating/cooling treatment, a carrier-free hydrogel (MF-gel) is developed by assembling the natural herbal molecule mangiferin, which is mainly governed through hydrogen bonds and intermolecular π−π stacking interactions. The asprepared hydrogel has injectable and self-healing properties and shows excellent biocompatibility, continuous release ability, and reversible stimuli-responsive performances. All of the superiorities enable the MFbased hydrogel to serve as a potential wound dressing for treating diabetic wounds, which was further confirmed by both the vitro and vivo studies. In vitro, the MF-gel could promote the migration of healing-related cells from peripheral as well as the angiogenesis and displays the capacity of mediating inflammation response by scavenging the intracellular ROS. In vivo, the MF-gel accelerates wound contraction and healing via inflammatory adjustment, collagen deposition, and angiogenesis. This study provides a facile and effective method for diabetic wound management and emphasizes the direct self-assembly hydrogel from natural herbal small molecule.

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“…It can exhibit antioxidant, antiinflammatory, immunomodulatory, antibacterial, and anti-obesity effects. Due to these effects, it is a promising adjuvant therapeutic to chronic disorders such as cardiovascular, renal, and pulmonary diseases; neurodegenerative disorders; obesity; diabetes; and metabolic syndrome [2,[9][10][11]. Table 1 shows the main bioactive compounds of mango and its by-products.…”

Section: Introductionmentioning

confidence: 99%

Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review

Minniti,

Laurindo,

Machado

et al. 2023

Life

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Mango and its by-products have traditional medicinal uses. They contain diverse bioactive compounds offering numerous health benefits, including cardioprotective and metabolic properties. This study aimed to explore the impact of mango fruit and its by-products on human health, emphasizing its metabolic syndrome components. PUBMED, EMBASE, COCHRANE, and GOOGLE SCHOLAR were searched following PRISMA guidelines, and the COCHRANE handbook was utilized to assess bias risks. In vivo and in vitro studies have shown several benefits of mango and its by-products. For this systematic review, 13 studies met the inclusion criteria. The collective findings indicated that the utilization of mango in various forms—ranging from fresh mango slices and mango puree to mango by-products, mango leaf extract, fruit powder, and mangiferin—yielded many favorable effects. These encompassed enhancements in glycemic control and improvements in plasma lipid profiles. Additionally, mango reduces food intake, elevates mood scores, augments physical performance during exercise, improves endothelial function, and decreases the incidence of respiratory tract infections. Utilizing mango by-products supports the demand for healthier products. This approach also aids in environmental conservation. Furthermore, the development of mango-derived nanomedicines aligns with sustainable goals and offers innovative solutions for healthcare challenges whilst being environmentally conscious.

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Pharmacological properties of mangiferin: bioavailability, mechanisms of action and clinical perspectives

Cited by 6 publications

References 105 publications

Box–Behnken Design to Optimize Standardized Mangiferin-Rich Mango Peel Extract from Agro-Industrial Waste Product

Box–Behnken Design to Optimize Standardized Mangiferin-Rich Mango Peel Extract from Agro-Industrial Waste Product

A Multifunctional Hydrogel Fabricated by Direct Self-Assembly of Natural Herbal Small Molecule Mangiferin for Treating Diabetic Wounds

Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review

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