Pharmacological profiling of Argemone mexicana for its aphrodisiac potentials in male Wistar rats

Asuntha, G.; Prasanna, Raju Y; Harini, Chowdary V; Vandana, K.R.; Arun, Rasheed; Prasad, K. V. S. R. G.

doi:10.1016/s2305-0500(14)60013-0

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…The exceedingly responsive female (in estrous stage) was brought into the home cage of the male rats and the accompanying male sexual behavioral parameters were recorded amid a time of 30 min: Latency (time) of first mount, number of mounts, latency of first intromission, number of intromission, latency of ejaculation (time from intromission to ejaculation), number of ejaculations. All the groups were tested for copulatory behavior on 0, 7th, 14th, 21st and 28th days [9].…”

Section: Sexual Behavior Studymentioning

confidence: 99%

Effect of Hydroalcoholic Extract of Capparis decidua (Forssk.) Edgew on Sexual Behavior of Male Rats

Dhakad¹,

Sharma²,

Kumar³

2018

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Capparis decidua has traditionally been recommended as an aphrodisiac agent. Although, it's medicinal use has not been scientifically proved. The present study therefore evaluated the effects of hydroalcoholic extract of C. decidua roots, stem and leaf on sexual behavior in normal male rats. The hydroalcoholic extract of C. decidua was administered (100 mg/kg, 200mg/kg) to different groups of male wistar rats for 28 days. The female rats were brought in estrous phase before the mating in each group of male rats. Standard group was administered sildenafil citrate at 5mg/kg orally for 28 days. Control group was administered only distilled water. All the experimental groups i.e C. decidua 100mg/kg, 200 mg/kg, per se group (only C. decidua 200 mg/kg), standard group(sildenafil citrate 5mg/kg) were compared with the control group for parameters evaluated for sexual behavior study. C. decidua at 100mg/kg, 200 mg/kg, and per se treated groups produced significant arousal of sexual activity in male rats. They significantly increased the frequencies of mount, intromission frequency. The mount latency and intromission latency were significantly reduced but ejaculation latency was prolonged significantly. The results indicated that hydroalcoholic extract of C. decidua enhanced sexual behaviour in male rats. The enhanced sexual behavior in male rats at the doses of 100 and 200 mg/kg body weight may be due to the presence of phytochemicals like alkaloids, saponins, flavonoids as these phytochemicals has role in increasing sexual strength, androgen enhancing, and antioxidant activity.

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Section: Sexual Behavior Studymentioning

confidence: 99%

Effect of Hydroalcoholic Extract of Capparis decidua (Forssk.) Edgew on Sexual Behavior of Male Rats

Dhakad¹,

Sharma²,

Kumar³

2018

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“…Argemone mexicana L. (Figure 1) which belongs to the family of Papaveraceae, is naturalized throughout the world's tropical and subtropical regions and grows as a prickly poppy shrub [8][9][10][11][12]. A. mexicana has been studied in vitro and in vivo for a variety of biological activities of numerous solvent extracts of the various parts of the plant; for example, it is used in the indigenous system of medicine as an analgesic and antiinfammatory [13][14][15], antiurolithiatic [16], anticancer [17,18], antioxidant [18], thrombolytic [19], antidiabetic [20][21][22], antiarthritic [23], cytotoxic [24,25], antipsychotic [26], antepileptics [27], apoptotic [18,28], aphrodiasic [29], antiasmatic [30], antihepatotoxic [31], nematocidal [32], antischistosomal [33], and antimalarial [34,35] wound healing [36,37] activities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Ayele

Abebe

Muche

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Introduction. The solvent fractions of the fruits of Argemone mexicana L. (Papaveraceae) have not yet been explored scientifically for in vivo wound healing and anti-inflammatory activities. The objective of this study was, therefore, to evaluate in vivo wound healing and anti-inflammatory activities of the solvent fractions of the fruit of Argemone mexicana L. (Papaveraceae) in rats. Method. The crude extract of Argemone mexicana was fractionated with n-hexane, ethyl acetate, and distilled water. Wound healing activity was evaluated using excision and incision wound models while anti-inflammatory activity was evaluated using carrageenan-induced rat paw and cotton pellet-induced granuloma models. The fractions were evaluated at 5 and 10% ointments using moist-exposed burn ointment as the standard drug, and 100, 200, and 400 mg/kg test doses using aspirin, and dexamethasone as standard drugs for wound healing and anti-inflammatory activities, respectively. All treatment administrations were made orally for anti-inflammatory activity and applied topically for wound healing activity. Result. The 10% w/w ethyl acetate fraction ointment showed a significant percentage of wound contraction, reduced period of epithelialization, increased amount of fibrosis, neovascularization, and collagen tissue formation ( p < 0.01 ). The ethyl acetate fraction also showed a significant increase in tensile strength (55%; p < 0.01 ) and (81.10%; p < 0.01 ) at the tested doses of 5 and 10% w/w ointments, which was comparable to moist-exposed burn ointment. The ethyl acetate fraction also revealed a significant percent edema inhibition (61.41%; p < 0.01 ), suppression of the exudate (38.09% p < 0.01 ), and granuloma mass formations (53.47% p < 0.01 ) at the tested dose of 400 mg/kg. Conclusion. The results of this study showed that the Ethyl acetate fraction of Argemone mexicana fruit has significant wound healing and anti-inflammatory activities which support the traditional claims of the experimental plant.

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Pharmacological profiling of Argemone mexicana for its aphrodisiac potentials in male Wistar rats

Cited by 2 publications

References 14 publications

Effect of Hydroalcoholic Extract of Capparis decidua (Forssk.) Edgew on Sexual Behavior of Male Rats

Effect of Hydroalcoholic Extract of Capparis decidua (Forssk.) Edgew on Sexual Behavior of Male Rats

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

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