Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels

Huang, Liping; Abuhamdah, Sawsan; Howes, Melanie‐Jayne R.; Dixon, Curt B.; Elliot, Mark S. J; Ballard, Clive; Holmes, Clive; Burns, Alistair; Perry, Elaine K.; Francis, Paul T.; Lees, George E.; Chazot, Paul L.

doi:10.1211/002235709788610417

Cited by 11 publications

(21 citation statements)

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“…This batch of (Mo) was selected and validated based on previous pharmacological and chemical studies using batches from four common suppliers (Baldwins (London, UK), Pranarom (Lille, France), Quinessence (Coalville, UK), Fytosan (Die, France); the composition correlates with the natural products Herbal Pharmacopoeia standards and was confirmed to be stable throughout the research programme (Dr Melanie-Jayne Howes, Jodrell Laboratory, Kew Gardens). Furthermore, a batch was selected and used in a parallel clinical trial in late-stage of Alzheimer's disease patients [18,19]. The GC-MS profile carried out at the Royal Botanic Garden at Kew (London), displayed no major changes in (Mo) composition following long-term storage (18 months) at 4°C in the dark (composition reported previously in [18,19]).…”

Section: Chemicals and Herb Samplesmentioning

confidence: 81%

“…Furthermore, a batch was selected and used in a parallel clinical trial in late-stage of Alzheimer's disease patients [18,19]. The GC-MS profile carried out at the Royal Botanic Garden at Kew (London), displayed no major changes in (Mo) composition following long-term storage (18 months) at 4°C in the dark (composition reported previously in [18,19]). Dilutions of essential oil stocks or components were performed fresh on the day of assay.…”

Section: Chemicals and Herb Samplesmentioning

confidence: 81%

“…35 S] TBPS binding and electrophysiological methodologies [18,19]. Results presented in this study show that, in concentration dependent manner, most of the (Mo) constituents demonstrated only modest antagonistic effects on […”

Section: Effects Of Melissa Essential Oil (Mo) On Neuronal Viabilitymentioning

confidence: 83%

“…Previous studies [18,19] suggest that (Mo) may display neuro protective properties, via a sodium channel blockade mechanism. This potential was investigated using a primary neuronal culture system as described in [16].…”

Section: Effects Of Melissa Essential Oil (Mo) On Neuronal Viabilitymentioning

confidence: 97%

“…The great molecular diversity of the multi-subunit hetero-oligomeric GABA A receptor provides opportunities to develop novel drugs, for example for anxiety, sleep disorders, alcoholism and epilepsy by establishing the relevant molecular targets for receptor subtype specific action [15][16][17]. In this present report, we attempted to identify the component that probably accounts for GABA A receptor binding properties of the Melissa and Lavender essential oils [18,19].…”

Section: Introductionmentioning

confidence: 99%

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Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils

Mahita¹,

Abuhamdah²,

Howes³

et al. 2014

EJMP

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Aims: Melissa officinalis (Mo) and Lavandula angustifolia (La) essential oils and their major constituents ((E) -caryophyllene, caryophyllene oxide, geranyl acetate, linalool, nerol, Oct-1-en-3-ol, 3-Octanone, myrcene, allo-ocimene, p-cymene and α-terpineol) assessed by GC-MS) which are shared by these two essential oils were probed in an attempt to identify the GABA A R ligand(s). [810][811][812][813][814][815][816][817][818] 2014 811 IC 50 of 40 M. Concentrations (0.001 mg/ml) of whole (Mo) were shown to display modest beneficial effects upon neuronal viability while at a higher concentration (0.1 mg/ml) of (Mo) and (La) oils induced a neurotoxicity effect. Conclusion: These data provide the first evidence that allo-ocimene is an neuroactive GABA A R inhibitory component found in both (Mo) and (La), and represents a novel GABA A receptor channel chemotype derived from a natural product.

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Section: Chemicals and Herb Samplesmentioning

confidence: 81%

Section: Chemicals and Herb Samplesmentioning

confidence: 81%

Section: Effects Of Melissa Essential Oil (Mo) On Neuronal Viabilitymentioning

confidence: 83%

Section: Effects Of Melissa Essential Oil (Mo) On Neuronal Viabilitymentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils

Mahita¹,

Abuhamdah²,

Howes³

et al. 2014

EJMP

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GABA_A receptor modulation by terpenoids from Sideritis extracts

Kessler

Sahin‐Nadeem

Lummis

et al. 2013

Molecular Nutrition Food Res

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ScopeGABAA receptors are modulated by Sideritis extracts. The aim of this study was to identify single substances from Sideritis extracts responsible for GABAA receptor modulation.Methods and resultsSingle volatile substances identified by GC have been tested in two expression systems, Xenopus oocytes and human embryonic kidney cells. Some of these substances, especially carvacrol, were highly potent on GABAA receptors composed of α1β2 and α1β2γ2 subunits. All effects measured were independent from the presence of the γ2 subunit. As Sideritis extracts contain a high amount of terpenes, 13 terpenes with similar structure elements were tested in the same way. Following a prescreening on α1β2 GABAA receptors, a high-throughput method was used for identification of the most effective terpenoid substances on GABA-affinity of α1β2γ2 receptors expressed in transfected cell lines. Isopulegol, pinocarveol, verbenol, and myrtenol were the most potent modifiers of GABAA receptor function.ConclusionComparing the chemical structures, the action of terpenes on GABAA receptors is most probably due to the presence of hydroxyl groups and a bicyclic character of the substances tested. We propose an allosteric modulation independent from the γ2 subunit and similar to the action of alcohols and anesthetics.

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Molecules from nature: Reconciling biodiversity conservation and global healthcare imperatives for sustainable use of medicinal plants and fungi

Howes

Quave

Collemare

et al. 2020

Plants People Planet

118

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Plants and fungi have provided, or inspired, key pharmaceuticals for global health challenges, including cancer, heart disease, dementia, and malaria, and are valued as traditional medicines worldwide. Global demand for medicinal plants and fungi has threatened certain species, contributing to biodiversity loss and depletion of natural resources that are important for the health of humanity. We consider the evolving role of plants and fungi in global healthcare as new challenges to human health and to biodiversity arise. We present current and emerging scientific approaches, to uncover and preserve nature‐based health solutions for the future, through harmonization with biodiversity conservation strategies.

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Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels

Cited by 11 publications

References 0 publications

Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils

Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils

GABA_A receptor modulation by terpenoids from Sideritis extracts

Molecules from nature: Reconciling biodiversity conservation and global healthcare imperatives for sustainable use of medicinal plants and fungi

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Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels

Cited by 11 publications

References 0 publications

Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils

Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils

GABAA receptor modulation by terpenoids from Sideritis extracts

Molecules from nature: Reconciling biodiversity conservation and global healthcare imperatives for sustainable use of medicinal plants and fungi

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Product

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GABA_A receptor modulation by terpenoids from Sideritis extracts