Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil

Orellana-Paucar, Adriana; Machado-Orellana, María Gabriela

doi:10.3390/molecules27165055

Cited by 12 publications

(10 citation statements)

References 84 publications

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“…Based on these results, it can be concluded that TEO contains phenolic and terpenoid compounds. Several studies reported that TEO has powerful antioxidant potential both in-vitro and in-vivo [2,8,31]. Oxygenated monoterpenes and sesquiterpenes, such as ar-turmerone, α-turmerone, and βturmerone, were included in the terpenoid compounds and reported to play a role in this activity.…”

Section: Identification Of Teomentioning

confidence: 99%

Response surface methodology for optimization of turmeric essential oil-loaded nanoemulgel

NINING,

AMALIA,

ZAHROK

2023

jrp

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Turmeric Essential Oil (TEO) has an antioxidant and anti-inflammatory activity to be formulated in a topical dosage form. Nanoemulgels (Negs) development, based on varying concentrations of emulsifiers and gel formers, affects their characteristics and stability. This study focuses on optimizing TEO-loaded Negs based on physical and mechanical characterization, which have promising topical applications. Negs were created using the high-energy approach and optimized using Response Surface Methodology (RSM) and the Central-Composite Design (CCD) for the optimization of span-80/tween-80 (X1) and Carbopol ® 980. (X2). Observed variable responses were particle size (PS) (Y1), polydispersity index (PDI) (Y2), zeta potential (ZP) (Y3), pH (Y4), spreadability (Y5), and adhesion time (AT) (Y6). Actual responses of Negs were compared with the CCD-RSM predictions to validate the model. In addition, other physical evaluations were observed, such as organoleptic observations, homogeneity, freeze-thaw tests, viscosity, and flow properties. Optimized TEO-loaded Negs were made with 8.68% span-80/tween-80 and 1.18% Carbopol ® 980. The evaluation results showed the optimal TEO-loaded Negs on nano-metric size (182.3 ± 5.5 nm) with low PDI (0.242 ± 0.003), good ZP (-57.23 ± 2.91 mV), pH (4.51 ± 0.02), spreadability (6.0 ± 0.2 cm), and AT (6.45 ± 0.19 s). TEO-loaded Negs have an excellent appearance and did not run phase separation at extreme temperature storage with pseudoplastic thixotropy flow. Thus, the developed TEO-loaded Negs can be a potential delivery system and a promising suitable approach for topical preparations.

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Section: Identification Of Teomentioning

confidence: 99%

Response surface methodology for optimization of turmeric essential oil-loaded nanoemulgel

NINING,

AMALIA,

ZAHROK

2023

jrp

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“…Orellana-Paucar et al presented another interesting review about turmeric oil [ 17 ]. The aims of this review were to discuss its pharmacokinetics, pointing to a potential application of its active molecules in therapy.…”

Section: Contributionsmentioning

confidence: 99%

Natural Products: Therapeutic Properties and Beyond II

2022

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“…The constituents of the leaf, rhizome, and flowers of C. longa have been extensively studied [ 21 , 22 , 23 ]. The rhizome essential oil has been reported to exhibit antimicrobial, anti-cancer, insecticidal, larvicidal, repellent, and antioxidant activities [ 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Mosquito Larvicidal Activity and Cytotoxicity of the Extracts of Aromatic Plants from Malaysia

Lim

Lee

et al. 2023

Insects

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Despite ongoing control efforts, the mosquito population and diseases vectored by them continue to thrive worldwide, causing major health concerns. There has been growing interest in the use of botanicals as alternatives to insecticides due to their widespread insecticidal properties, biodegradability, and adaptability to ecological conditions. In this study, we investigated the larvicidal activity and cytotoxicity effects of solvent extracts from three aromatic plants—Curcuma longa (turmeric), Ocimum americanum (hoary basil), and Petroselinum crispum (parsley)—against Aedes albopictus. Subsequently, we examined the phytochemical composition of the extracts through gas chromatography–mass spectrometry (GC–MS) analysis. Results revealed that the hexane extracts of O. americanum and P. crispum exhibited the greatest larvicidal activity with the lowest median lethal concentration (LC50) values (<30 µg/mL) at 24 h post-treatment, with the former found to be significantly less toxic towards African monkey kidney (Vero) cells. The GC–MS analysis of the said extract indicated the presence of different classes of metabolites, including phenylpropanoids, very long-chain alkanes, fatty acids and their derivatives, and terpenes, with the most abundant component being methyl eugenol (55.28%), most of which, have been documented for their larvicidal activities. These findings provide valuable insights into the potential use and development of bioinsecticides, particularly from O. americanum.

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Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil

Cited by 12 publications

References 84 publications

Response surface methodology for optimization of turmeric essential oil-loaded nanoemulgel

Response surface methodology for optimization of turmeric essential oil-loaded nanoemulgel

Natural Products: Therapeutic Properties and Beyond II

Mosquito Larvicidal Activity and Cytotoxicity of the Extracts of Aromatic Plants from Malaysia

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