Natural Products: Therapeutic Properties and Beyond II

Duarte, Ana Paula; Luís, Ângelo; Gallardo, Eugénia

doi:10.3390/molecules27196140

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Natural products, as a research hotspot for the treatment of various diseases in recent years, have the advantages of a diverse range of species, high safety, and wide pharmacological effects, which can compensate for the drawbacks of many existing medications, such as general efficacy and large side effects ( Ginwala et al, 2019 ; Duarte et al, 2022 ). With the development of metabolomics, genomics, bioinformatics, and other technologies, it is possible to better develop and apply natural bioactive components to clinical practice ( Atanasov et al, 2021 ).…”

Section: Potential Drugs Targeting Jak/stat For Dkd Treatmentmentioning

confidence: 99%

JAK/STAT signaling in diabetic kidney disease

Liu

Wang

Zhang

et al. 2023

Front. Cell Dev. Biol.

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Diabetic kidney disease (DKD) is the most important microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD) worldwide. The Janus kinase/signal transducer and activator of the transcription (JAK/STAT) signaling pathway, which is out of balance in the context of DKD, acts through a range of metabolism-related cytokines and hormones. JAK/STAT is the primary signaling node in the progression of DKD. The latest research on JAK/STAT signaling helps determine the role of this pathway in the factors associated with DKD progression. These factors include the renin–angiotensin system (RAS), fibrosis, immunity, inflammation, aging, autophagy, and EMT. This review epitomizes the progress in understanding the complicated explanation of the etiologies of DKD and the role of the JAK/STAT pathway in the progression of DKD and discusses whether it can be a potential target for treating DKD. It further summarizes the JAK/STAT inhibitors, natural products, and other drugs that are promising for treating DKD and discusses how these inhibitors can alleviate DKD to explore possible potential drugs that will contribute to formulating effective treatment strategies for DKD in the near future.

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Section: Potential Drugs Targeting Jak/stat For Dkd Treatmentmentioning

confidence: 99%