Pharmacological Principles Used in Patient Monitoring with Type 2 Diabetes

Abstract

This study assessed the medication used in type 2 diabetes treatment, depending on the glycaemia level and set out the oral anti-diabetics which are recommended, in three study stages: admission, hospitalization and discharge. Eighty patients were selected and diagnosed with diabetes mellitus 2 type, who were registered in the diabetes and nutrition diseases department within Sf. Apostol Andrei Galati Hospital. They were subjected to a series of laboratory tests: blood count, glycosylated haemoglobin, glycaemia level. It were established main classes of anti-diabetic drugs outpatient used and the main types of anti-diabetic agents administrated to patients requiring hospitalization, compared to high glycaemia values. It was given also, the medication used to normalize blood glucose levels during hospitalization and also at discharge. The biguanides associated with sulphonylureas drugs did not provide an adequate glycaemia control, so insulin must be combined with Metformin to normalize blood glucose levels as soon as possible. Glycaemia control was improved and the hypoglycaemia risk was reduced regarding obese patient undergoing treatment with insulin, to whom biguanides were administered.

Evaluation of Metabolic and Hydroelectrolytic Disturbances in Patients Diagnosed with Diabetic Ketoacidosis

“…The metabolism of all major biomolecules is affected in diabetic ketoacidosis: carbohydrate, protein and lipid metabolic pathways are disturbed. Medication of diabetic subjects should always been adapted to the current needs of the patients [12]. Acidosis contributes to hyperpotassemia, administration of glucose and insulin lowers the level of potassium [9].…”

Coordination Compounds of Platinum and Palladium with Mixed Ligands (Usnic Acid and 1-(o-Tolyl) Biguanide) � Synthesis, Spectral Characterization and Biological Activity

“…Biguanides and related compounds have remained an important area of research, especially for their wide applications, due to their antibacterial, antifungal, antimalarial, hypoglycemic or antitumor activities [1][2][3][4][5][6][7][8]. Biguanides have also a remarkable coordination capability to various metal ions and the resulting complexes have often higher biological activity than ligands [9][10][11].…”

Complexes of Cu (II) with a-Ketoglutaric Acid and 1- (o-tolyl) Biguanide Synthesis, characterization and biological Activity

“…Biguanides are compounds exhibiting important biological properties, e.g. antibacterial, antifungal, hypoglycaemic, antimalaric and antitumor activity [9][10][11][12][13][14][15][16]. Many of the complex combinations in which the ligand is part of this class of compounds have biological properties, which explains the particular interest in their study.…”