Pharmacological preconditioning with erythropoietin reduces ischemia–reperfusion injury in the small intestine of rats

Sayan, Hale; Özaçmak, Veysel Haktan; Şen, Feyza; Cabuk, Mehmet; Atik, Duygu Yörük; Igdem, Aysenur Akyildiz; Ozacmak, I. Diler

doi:10.1016/j.lfs.2008.12.025

Cited by 23 publications

(19 citation statements)

References 35 publications

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“…It has also been demonstrated that EPO protects against intestinal ischemia/reperfusion injury in rats by reducing oxidative stress, apoptosis, and leukocyte infiltration [107,108] .…”

Section: Tissue-protective Effects Of Epomentioning

confidence: 99%

Erythropoietin: A Hormone with Multiple Functions

2011

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Erythropoietin (EPO), the main hemopoietic hormone synthesized by the kidney as well as by the liver in fetal life, is implicated in mammalian erythropoiesis. Production and secretion of EPO and the expression of its receptor (EPO-R) are regulated by tissue oxygenation. EPO and EPO-R, expressed in several tissues, exert pleiotropic activities and have different effects on nonhemopoietic cells. EPO is a cytokine with antiapoptotic activity and plays a potential neuroprotective and cardioprotective role against ischemia. EPO is also involved in angiogenesis, neurogenesis, and the immune response. EPO can prevent metabolic alterations, neuronal and vascular degeneration, and inflammatory cell activation. Consequently, EPO may be of therapeutic use for a variety of disorders. Many tumors express EPO and/or EPO-R, but the action of EPO on tumor cells remains controversial. It has been suggested that EPO promotes the proliferation and survival of cancer cells expressing EPO-R. On the other hand, other reports have concluded that EPO-R plays no role in tumor progression. This review provides a detailed insight into the nonhemopoietic role of EPO and its mechanism(s) of action which may lead to a better understanding of its potential therapeutic value in diverse clinical settings.

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“…It has also been demonstrated that EPO protects against intestinal ischemia/reperfusion injury in rats by reducing oxidative stress, apoptosis, and leukocyte infiltration [107,108] .…”

Section: Tissue-protective Effects Of Epomentioning

confidence: 99%

Erythropoietin: A Hormone with Multiple Functions

2011

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“…Moreover, EPO protected the antioxidant capacity of the ileum by slightly preventing catalase and GSHrx enzyme activity loss. Glutathione level is a reliable marker of antioxidant capacity and its high level correlates with EPO usage and less tissue damage [10]. However, the low number of the subjects in the groups and a few parameters assessed could be suggested as limitations of this study.…”

Section: Discussionmentioning

confidence: 91%

“…EPO, the production of which mostly increases with hypoxia/ischemia, reduces the production of free oxygen radicals, oxidative stress, inflammation and apoptosis. It protects tissues from damage and allows the repair of tissues because of such features as angiogenesis and neuroprotection [6][7][8][9][10][11][12]. EPO also improves the immune response by increasing the number of T and B lymphocytes and the amount of immunoglobulin [9].…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Erythropoietin on Intestinal Damage Developed Secondary to Experimental Acute Pancreatitis

M¹

2012

Pancreat Disorders Ther

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“…Versatility preconditioning mechanism gives the background to the study of this phenomenon on the retina. One of the most promising is the AF EPO agents precondition his action has been studied in the brain [21], the spinal cord [22], kidney [23], the small intestine [24] heart [25,26].…”

Section: Discussionmentioning

confidence: 99%

Correction of Ischemic Damage to the Retina on Application of Pharmacological Preconditioning of Recombinant Erythropoietin

Shabelnikova¹

2016

RR.P and CP

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Abstract. To study the protective properties of pharmacological preconditioning with recombinant erythropoietin suberitro stimulating dose of 50 IU / kg in the retina of the eye, was the model of retinal ischemia, ischemia with the assessment of the temporary simulation mode of the retina of rats with the instrumental methods of analysis and morphometric studies. The most suitable model was a model 30 minute ischemia with subsequent reperfusion periods of 1 hour to 72 hours. We studied the protective effect preconditioning suberitro stimulating recombinant erythropoietin in a dose of 50 IU/kg, preconditioning distant ischemic and emoxipine 2 mg/kg per rat model of retinal ischemia. In the experiment, it was revealed that the recombinant erythropoietin (50 IU/kg) prevents the development of degenerative retinal layers due to ischemic damage more than distant ischemic preconditioning and emoxipine. The observed protective effect of erythropoietin us with the development of ischemia was confirmed by laser Doppler flowmetry, electroretinography and morphometry. Using suberitro stimulating recombinant erythropoietin in a dose of 50 IU/kg, 30 minutes prior to the pathology simulation eliminates erythropoietic effect, and the lack of positive dynamics in groups with preliminary administration of glibenclamide 5 mg/kg, the key role of ATP-dependent potassium channels in a preconditioning mechanism implementation. Identification and use of pharmacological agents, which have the effect of preconditioning, may be a new approach in the correction and prevention of retinal ischemia, which is the leading element in the pathogenesis of a number of visual pathologies. The possibility of pharmacological preconditioning with erythropoietin ischemic lesions of the retina is essential for the development of anti-ischemic agents for the treatment and prevention of ocular pathologies of ischemic origin.

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Pharmacological preconditioning with erythropoietin reduces ischemia–reperfusion injury in the small intestine of rats

Cited by 23 publications

References 35 publications

Erythropoietin: A Hormone with Multiple Functions

Erythropoietin: A Hormone with Multiple Functions

The Effect of Erythropoietin on Intestinal Damage Developed Secondary to Experimental Acute Pancreatitis

Correction of Ischemic Damage to the Retina on Application of Pharmacological Preconditioning of Recombinant Erythropoietin

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