Pharmacological potentials of <i>Syzygium cumini</i>: a review

Srivastava, Shalini; Chandra, Deepak

doi:10.1002/jsfa.6111

Cited by 99 publications

(72 citation statements)

References 67 publications

(107 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The plant has been reported to contain anthocyanins, glucoside, ellagic acid, isoquercetin, kaemferol, and myrecetin (Aqil et al, 2012;Kumar et al, 2009;Sagrawat et al, 2006;Simoes-Pires et al, 2009). The seeds are claimed to contain alkaloids, jambosine, and glycoside, jamboline or antimellin, which halt the diastatic conversion of starch into sugar (Ayyanar & Babu, 2012;Gowri & Vasantha, 2010;Srivastava & Chandra, 2013).…”

Section: Introductionmentioning

confidence: 99%

Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds fromSyzygium cuminiseeds

Sawant

Singh

Dethe

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Syzygium cumini (L.) Skeels (Myrtaceae), commonly known as jamun, is an Indian plant, traditionally well known for its medicinal properties including antidiabetic activity. Objective: To isolate the antidiabetic compounds from Syzygium cumini seeds and evaluate their activity using aldose reductase (AR) and protein-tyrosine phosphatase 1B (PTP1B) inhibition assays. Materials and methods:The dried seeds were extracted with methanol and partitioned with ethyl acetate, butanol, and water. The extracts were screened for antidiabetic activity at a concentration of 100 mg/mL using in vitro AR and PTP 1B inhibition assays. Results and discussion: The highly enriched fractions obtained from broad ethyl acetate fraction yielded maslinic acid (1), 5-(hydroxymethyl) furfural (2), gallic acid (3), valoneic acid dilactone (4), rubuphenol (5), and ellagic acid (6). Structures were elucidated by 1 H-NMR and 13 C-NMR. The initial ethyl acetate fraction showed AR inhibitory activity with the IC 50 value of 2.50 mg/mL and PTP1B enzyme inhibition with the IC 50 value of 26.36 mg/mL. Compounds 3, 4, 5, and 6 were found to inhibit AR with IC 50 values of 0.77, 0.075, 0.165, and 0.12 mg/mL while the compounds 4, 5, and 6 inhibited PTP1B with IC 50 values of 9.37, 28.14, and 25.96 mg/mL, respectively. Conclusion:The results of this study demonstrate that the isolated constituents show promising in vitro antidiabetic activity and, therefore, can be candidates for in vivo biological screening using relevant models to ascertain their antidiabetic activity.

show abstract

Section: Introductionmentioning

confidence: 99%

Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds fromSyzygium cuminiseeds

Sawant

Singh

Dethe

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…In both studies, it was possible to show a significant reduction in gastrointestinal motility in tests of coal meal in rats. The underlying mechanism of action of the plant extract appeared to be antispasmodic whereby the extract produced relief from diarrhea (Mukherjee et al, 1998;Shamkuwar et al, 2012;Srivastava and Chandra, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…The antidiarrhoeal activity was investigated using extracts obtained from the stem bark and seeds of S. cumini (Mukherjee et al, 1998;Mazumder et al, 2006;Shamkuwar et al, 2012;Chandra, 2013). However, there is no report available on the hydro-alcoholic extract of the leaves of S. cumini on its anti-diarrhoeal or antispasmodic activity despite its medicinal use in diarrhoea.…”

Section: Introductionmentioning

confidence: 99%

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

Monteiro¹,

Carvalho²,

Marques³

et al. 2018

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Syzygium cumini L. Skeels (Myrtaceae) commonly known as jambolan is used as traditional medicine to treat gastrointestinal disorders in children in Brazil. This work is one of the first to evaluate the antidiarrhoeal and antispasmodic activity of the standardized extract of S. cumini leaves (HESc) in experimental models in vitro and in vivo rodents. Mice pre-treated with HESc (100, 250 and 1000 mg/kg) and atropine (1.0 mg/kg) had reduced intestinal transit velocity of 11.0; 23.2 and19.1%, respectively compared to saline control (46.6±0.9). In isolated rats jejunum, HESc (50, 150 and 300 µg/mL) shifted to the right cumulative concentration-response curves to ACh with changing maximum effect (E max ), which is characteristic of non-competitive antagonism to ACh. HESc also promoted relaxation (E max 90.2±5.8%) in preparations pre-contacted with KCl (75 mM). Additionally, it reduced the maximal CaCl 2 -induced response in 15.4; 56.3 and 92.1% in a concentration-dependent manner. The study results show that HESc has an antidiarrhoeal and spasmolytic potential that can be partly explained by the reduction of intestinal transit velocity and blockage of the voltage-dependent calcium channels in the smooth intestinal muscle.

show abstract

“…The bioactive constituents of the plant have various biological functions including antioxidant, anti-inflammatory, a nt ibact er ia l, a nt id iab et ic a nd ca rd ioprot e ct ive properties (99,100). A number of previous studies demonstrated the radioprotective role of S. cumini in the in vitro and in vivo systems (101)(102)(103)(104). Administration of S. cumini leaf extracts resulted in suppression of radiation-induced micronuclei formation and protection of lymphocytes against DNA damage (102).…”

Section: Zingiber Officinalementioning

confidence: 99%

Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy

et al. 2017

View full text Add to dashboard Cite

Abstract. The primary goal of radiotherapy in oncology is to enhance the efficacy of tumor cell death while decreasing damage to surrounding normal cells. Positive therapeutic outcomes may be accomplished by improved targeting, precisely targeting tumor cells or protecting normal cells against radiation-induced damage. The potential for antioxidants to decrease normal tissue damage induced by radiation has been investigated in animal models for a number of decades. In attempts for radioprotection, certain synthetic chemicals are suggested as antioxidants and normal tissue protectors against radiation-induced damage, but they have exhibited limitations in pharmacological application due to undesirable effects and high toxicities at clinical doses. The present review focuses on the radioprotective efficacy of traditional oriental medicines with the advantage of low toxicity at pharmacological doses and how such treatments may influence various harmful effects induced by radiation in vitro and in vivo. In addition, medicinal plants and their active constituents with biological activities that may be associated with alleviation of radiation-induced damage through antioxidant, anti-inflammatory, wound healing and immunostimulatory properties are discussed.

show abstract

Pharmacological potentials of Syzygium cumini: a review

Cited by 99 publications

References 67 publications

Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds fromSyzygium cuminiseeds

Aldose reductase and protein tyrosine phosphatase 1B inhibitory active compounds fromSyzygium cuminiseeds

Antidiarrhoeal and antispasmodic activity of leaves of Syzygium cumini L. (Myrtaceae) mediated through calcium channel blockage

Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy

Contact Info

Product

Resources

About