2017
DOI: 10.1016/j.bjp.2017.02.006
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Pharmacological potential of Maytenus species and isolated constituents, especially tingenone, for treatment of painful inflammatory diseases

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Cited by 36 publications
(16 citation statements)
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“…32 The opening of a potassium channel present in the membrane of vascular muscle cells causes an increase in ion output, from the intracellular medium into the extracellular medium, causing cell membrane hyperpolarization and then a blockade of voltagedependent Ca 2+ channels and a consequent decrease in the input of Ca 2+ ions into the intracellular medium, causing vascular relaxation. 32,33 Conversely, the closing of potassium channels causes a state of depolarization, opening of voltage-dependent Ca 2+ channels, increase in intracellular Ca 2+ and vasoconstriction. 32 This mechanism of smooth-muscle relaxation and contraction differs regarding the PHE mechanism of action, which directly stimulates the α-adrenergic receptors of the G protein, acting via phospholipase C, increasing the levels of IP3, and resulting in the release of intracellular Ca 2+ , causing muscular contraction.…”
Section: Discussionmentioning
confidence: 99%
“…32 The opening of a potassium channel present in the membrane of vascular muscle cells causes an increase in ion output, from the intracellular medium into the extracellular medium, causing cell membrane hyperpolarization and then a blockade of voltagedependent Ca 2+ channels and a consequent decrease in the input of Ca 2+ ions into the intracellular medium, causing vascular relaxation. 32,33 Conversely, the closing of potassium channels causes a state of depolarization, opening of voltage-dependent Ca 2+ channels, increase in intracellular Ca 2+ and vasoconstriction. 32 This mechanism of smooth-muscle relaxation and contraction differs regarding the PHE mechanism of action, which directly stimulates the α-adrenergic receptors of the G protein, acting via phospholipase C, increasing the levels of IP3, and resulting in the release of intracellular Ca 2+ , causing muscular contraction.…”
Section: Discussionmentioning
confidence: 99%
“…(bark, leaves, root). 30 The fluoxetine is a drug of the Selective Inhibitors of Serotonin Recaption family, whose site of action its located at the Synaptic cleft producing an increased and prolonged serotonergic transmission by stimulating many postsynaptic receptors. 31 Then, the antidepressant effect observed could be due to secondary metabolites present in the Maytenus macrocarpa's leaves, of which the most abundant are terpenes, among them the sesquiterpenes and terpenoids such as lupeol, friedeline and epifriedelinol, 32 which have been identified with antioxidant, anti-inflammatory, antinociceptive and antitumor properties, which will result in a neuroprotection effect of the central nervous system.…”
Section: Discussionmentioning
confidence: 99%
“…Estas diferencias de medias (DM) de aproximadamente 1,3 cm son bastante parecidas a las encontradas en estudios con otras plantas medicinales como el Camellia sinensis (32) -té verde-(DM: 3,75±4,63) y Artemisia annua (33) (DM: 2,6±3,84), pero diferentes a otras especies prometedoras como Sambucus ebulus (34) (DM: 0,77±0,58). El efecto analgésico observado a través de los resultados puede ser justificado por la presencia de algunos fitoconstituyentes como alcaloides: mayteína y 6-benzoil-6-deacetylmayteina, los cuales podrían estar inhibiendo la proteincinasa, una proteína que tiene participación en los mecanismos del dolor (24,25) . Se encontró también una disminución del puntaje referente a la capacidad funcional, teniendo un mejor desempeño la dosis de 80 mg/kg p.c.…”
Section: Discussionunclassified
“…Así mismo, se ha encontrado que los extractos derivados de esta especie tienen efectos antiinflamatorios, probablemente debido a sus componentes, entre los que destacan los terpenos y alcaloides como: 6-benzoil-6-deacetilmayteína, catequintaninos, maytansina, mayteína, maytenina (23,24). Estos compuestos inhiben los efectos de la prostaglandina E2 (PGE2) en macrófagos estimulados con endotoxinas bacterianas, y reducen la producción de citoquinas proinflamatorias como TNF-α, IL-6 y IL-1β (25) .…”
Section: Introductionunclassified