Pharmacological Modulation of the Cardiovascular Response to Hypertonic NaCl Injection in the Anteroventral Area of the Rat Brain Third Ventricle

Rosa, Francisco; Vásquez, J; Lupi, Johannes; Lezama, E; Romero-Vecchione, Eduardo

doi:10.1159/000139475

Cited by 3 publications

(2 citation statements)

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“…The brain anteroventral area of the third ventricle ( ⌬ V3V) has sodium-sensitive neurons and hypertonic 1.5 mol/l NaCl microinjections into ⌬ V3V induces a sympathetic peripheral discharge in the rat expressed as a long-lasting hypertensive and tachycardic response; this response can be modulated by locally administered antihypertensive drugs such as the angiotensin receptor blocker losartan and 5-HT 2 serotonin receptor antagonist ketanserin [22] . The objective of this work was to investigate the hemodynamic response of rats to ⌬ V3V microinjections of 1.5 mol/l NaCl after long-term testosterone and nandrolone treatment.…”

Section: Introductionmentioning

confidence: 99%

Testosterone and Nandrolone Sensitization of Brain Anteroventral Area of Third Ventricle to Hypertonic NaCl-Induced Sympathetic Response

et al. 2005

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Androgenic steroids increase atherogenesis, thrombogenicity and endothelial dysfunction when administered in high doses, however their effects on NaCl sensitivity of the brain anteroventral area of the third ventricle (ΔV3V) have not been explored. Sprague-Dawley male rats were anesthetized with sodium pentobarbital (40 mg/kg) and the femoral intra-arterial blood pressure and heart rate monitored through a strain-gauge blood pressure transducer and tachograph. ΔV3V microinjections of (2 µl) 1.5 mol/l NaCl solution were done according to brain coordinates: AP = 7.0 mm, L = 1.0 mm, D = 7.5 mm through a 0.2-mm diameter stainless steel needle. The injection site was verified with 1.0 µl neutral red solution. Basal systolic blood pressure increased 37.6 and 39.6 mm Hg after testosterone (1 mg/kg/day for 20 days) and nandrolone (1 mg/kg/day for 20 days) treatment respectively; diastolic blood pressure also increased upon testosterone and nandrolone treatment in 36.4 and 53.1 mm Hg, respectively; basal heart rate did not change. Vasopressor response to 1.5 mol/l NaCl ΔV3V microinjection was higher in testosterone-treated rats; systolic blood pressure increased 56.0 vs. 28.3 control mm Hg; diastolic blood pressure increased 54.0 vs. 25 control mm Hg. This hypertensive response was 29% longer lasting in testosterone compared to vehicle-treated rats. The same pattern of ΔV3V sensitization to hypertonic NaCl was observed in nandrolone-treated rats. Blood lipid profile changed to a proatherogenic fashion upon testosterone and nandrolone long-term treatment; the plasma-free testosterone concentration increased from 4.9 ± 0.9 to 36.0 ±7.1 pg/ml with the same testosterone treatment schedule. In conclusion, long-term androgenic steroid treatment sensitizes the brain ΔV3V region to hypertonic NaCl which in turn conducts into a sympathetic vasopressor and heart rate-stimulating action.

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Section: Introductionmentioning

confidence: 99%

Testosterone and Nandrolone Sensitization of Brain Anteroventral Area of Third Ventricle to Hypertonic NaCl-Induced Sympathetic Response

et al. 2005

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“…Plasma osmolality not only impacts salt appetite but also blood-pressure regulation. Blood pressure is regulated, in part, by the detection of changes in [Na + ] within the brain by osmosensitive neurons located near the anteroventral third ventricle region (AV3V) [ 177 , 178 , 179 ], including the SFO, OVLT, and MnPO. As discussed with sodium appetite, osmosensitive neurons express various [Na + ]-sensitive channels, including TPRV1, TRPV4, and Na x .…”

Section: Neural and Hormonal Control Of Blood-pressurementioning

confidence: 99%

Sodium Intake and Disease: Another Relationship to Consider

et al. 2023

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Sodium (Na+) is crucial for numerous homeostatic processes in the body and, consequentially, its levels are tightly regulated by multiple organ systems. Sodium is acquired from the diet, commonly in the form of NaCl (table salt), and substances that contain sodium taste salty and are innately palatable at concentrations that are advantageous to physiological homeostasis. The importance of sodium homeostasis is reflected by sodium appetite, an “all-hands-on-deck” response involving the brain, multiple peripheral organ systems, and endocrine factors, to increase sodium intake and replenish sodium levels in times of depletion. Visceral sensory information and endocrine signals are integrated by the brain to regulate sodium intake. Dysregulation of the systems involved can lead to sodium overconsumption, which numerous studies have considered causal for the development of diseases, such as hypertension. The purpose here is to consider the inverse—how disease impacts sodium intake, with a focus on stress-related and cardiometabolic diseases. Our proposition is that such diseases contribute to an increase in sodium intake, potentially eliciting a vicious cycle toward disease exacerbation. First, we describe the mechanism(s) that regulate each of these processes independently. Then, we highlight the points of overlap and integration of these processes. We propose that the analogous neural circuitry involved in regulating sodium intake and blood pressure, at least in part, underlies the reciprocal relationship between neural control of these functions. Finally, we conclude with a discussion on how stress-related and cardiometabolic diseases influence these circuitries to alter the consumption of sodium.

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Respuestas cardiovasculares al NaCl hipertónico inyectado en la región anteroventral del tercer ventrículo de ratas con hipertensión e insulinorresistencia inducidas por fructosa

Rosa

Romero-Vecchione

Vásquez

et al. 2007

Revista Española de Cardiología

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Pharmacological Modulation of the Cardiovascular Response to Hypertonic NaCl Injection in the Anteroventral Area of the Rat Brain Third Ventricle

Cited by 3 publications

References 0 publications

Testosterone and Nandrolone Sensitization of Brain Anteroventral Area of Third Ventricle to Hypertonic NaCl-Induced Sympathetic Response

Testosterone and Nandrolone Sensitization of Brain Anteroventral Area of Third Ventricle to Hypertonic NaCl-Induced Sympathetic Response

Sodium Intake and Disease: Another Relationship to Consider

Respuestas cardiovasculares al NaCl hipertónico inyectado en la región anteroventral del tercer ventrículo de ratas con hipertensión e insulinorresistencia inducidas por fructosa

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