Pharmacological modulation of edema mediated by prostaglandin, serotonin and histamine

Abstract

Previous studies demonstrated that the formamidine pesticide chlordimeform (CDM) reversibly inhibited prostaglandin biosynthesis and prevented the late (PG-mediated) phase of carrageenin-induced hind paw edema. This study emphasizes antagonism by CDM of the early (5HT and histamine-mediated) phase of carrageenin edema. CDM and cyproheptadine both antagonized paw edema induced by albumin (5HT and histamine-mediated) and by the direct injection of 5HT and histamine, whereas aspirin and the PG antagonist, SC-19220, were ineffective. As expected, cyproheptadine selectively reduced the early phase, whereas aspirin and SC-19220 selectively reduced the late phase of carrageenin-induced edema. These results are thus consistent with earlier studies demonstrating PG mediation of the late phase of carrageenin edema, and 5HT and histamine mediation of albumin edema and the early phase of carrageenin edema. In addition, they indicate that CDM possesses multiple acute anti-inflammatory actions not exhibited by aspirin, by SC-19220 or by cyproheptadine alone.

Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae)

“…The initial phase is attributed to the release of histamine and 5-HT. A second phase is mediated by kinins and finally in a third phase, the mediator is suspected to be prostaglandin (Di Rosa et al, 1971;Holsapple et al, 1980). Again, our results argue for inhibition of prostaglandin synthesis by the BuOH extract.…”

Excitation and sensitization of fine articular afferents from cat's knee joint by prostaglandin E2.

“…As such an -experimental inflammation is promoted by endogenous inflammatory mediators including PGE2 (Willis, 1969;DiRosa et al 1971;Blackham et al 1974;Moncada et al 1975;Higgs & Salmon, 1979;Holsapple et al 1980;Higgs & Moncada, 1983) it may be assumed that these mediators also contribute to the sensitization of group III and IV units from inflamed joints. The present data show that PGE2 is able to induce a long-lasting increase of sensitivity to movements in group III units including some of those having a high threshold to movements in the control period.…”

Design and synthesis of some thiazolotriazolyl esters as anti-inflammatory and analgesic agents

“…In addition, if the inhibition is more effective in the second phase of carrageenan-induced edema, it means that the reply is prostaglandin mediated (Holsapple et al, 1980). According to this literature information, it might be stated that our compounds show their anti-inflammatory effect through the PG-mediated mechanism (Table 1).…”