Pharmacological Mechanisms Underlying Gastroprotective Activities of the Fractions Obtained from Polygonum minus in Sprague Dawley Rats

Qader, Suhailah Wasman; Abdulla, Mahmood Ameen; Chua, Lee Suan; Sirat, Hasnah Mohd; Hamdan, Salehhuddin

doi:10.3390/ijms13021481

Cited by 40 publications

(28 citation statements)

References 33 publications

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“…These findings were matched with the previous study 52,53. Further, it suggests that GPx plays a remarkable intracellular antioxidant role in the defence of the gastric mucosa from impairment 10,54–57. In the present study, the lack of a submucosal area in the gastric layer mucosa and reduction of leukocyte infiltration in gastric wall sections is resulted of pre-fed rats with C. barometz .…”

Section: Discussionsupporting

confidence: 48%

The antiulcer effect of <em>Cibotium barometz</em> leaves in rats with experimentally induced acute gastric ulcer

Al-Wajeeh¹,

Hajrezaie²,

Al-Henhena³

et al. 2017

DDDT

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Cibotium barometz is a pharmaceutical plant customarily used in traditional medicine in Malaysia for the treatment of different diseases, such as gastric ulcer. The gastroprotective effect of C. barometz leaves against ethanol-induced gastric hemorrhagic abrasions in Sprague Dawley rats has been evaluated in terms of medicinal properties. Seven groups of rats (normal control and ulcerated control groups, omeprazole 20 mg/kg, 62.5, 125, 250, and 500 mg/kg of C. barometz correspondingly) were used in antiulcer experiment and pretreated with 10% Tween 20. After 1 hour, the normal group was orally administered 10% Tween 20, whereas absolute alcohol was fed orally to ulcerated control, omeprazole, and experimental groups. Gastric’s homogenate were assessed for endogenous enzymes activities. Stomachs were examined macroscopically and histologically. Grossly, the data demonstrated a significant decrease in the ulcer area of rats pretreated with plant extract in a dose-dependent manner with respect to the ulcerated group. Homogenates of the gastric tissue exhibited significantly increased endogenous enzymes activities in rats pretreated with C. barometz extract associated with the ulcerated control group. Histology of rats pretreated with C. barometz extract group using hematoxylin and eosin staining exhibited a moderate-to-mild disruption of the surface epithelium with reduction in submucosal edema and leucocyte infiltration in a dose-dependent manner. In addition, it showed heat shock protein70 protein up-expression and BCL2-associated X protein downexpression. These outcomes might be attributed to the gastroprotective and antioxidative effects of the plant.

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Section: Discussionsupporting

confidence: 48%

The antiulcer effect of <em>Cibotium barometz</em> leaves in rats with experimentally induced acute gastric ulcer

Al-Wajeeh¹,

Hajrezaie²,

Al-Henhena³

et al. 2017

DDDT

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“…A large number of medicinal plants with gastroprotective properties have been reported by gastric ulcer researchers [19–22]. Plant-based medicines represent a vast untapped source for medicines that have shown enormous therapeutic potential.…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity and Gastroprotective Role ofM. pruriensin Ethanol-Induced Gastric Mucosal Injuries in Rats

Golbabapour

Hajrezaie

Hassandarvish

et al. 2013

BioMed Research International

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The investigation was to evaluate gastroprotective effects of ethanolic extract of M. pruriens leaves on ethanol-induced gastric mucosal injuries in rats. Forty-eight rats were divided into 8 groups: negative control, extract control, ulcer control, reference control, and four experimental groups. As a pretreatment, the negative control and the ulcer control groups were orally administered carboxymethylcellulose (CMC). The reference control was administered omeprazole orally (20 mg/kg). The ethanolic extract of M. pruriens leaves was given orally to the extract control group (500 mg/kg) and the experimental groups (62.5, 125, 250, and 500 mg/kg). After 1 h, CMC was given orally to the negative and the extract control groups. The other groups received absolute ethanol. The rats were sacrificed after 1 h. The ulcer control group exhibited significant mucosal injuries with decreased gastric wall mucus and severe damage to the gastric mucosa. The extract caused upregulation of Hsp70 protein, downregulation of Bax protein, and intense periodic acid schiff uptake of glandular portion of stomach. Gastric mucosal homogenate showed significant antioxidant properties with increase in synthesis of PGE2, while MDA was significantly decreased. The ethanolic extract of M. pruriens leaves was nontoxic (<5 g/kg) and could enhance defensive mechanisms against hemorrhagic mucosal lesions.

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“…Traditionally, plants are used for medicinal purposes in different countries. Nowadays, researchers and companies are inclined to investigate more about herbal medicines, and many plants with antiulcerogenic properties have been found by different groups [4–7]. …”

Section: Introductionmentioning

confidence: 99%

Gastroprotective Activity ofPolygonum chinenseAqueous Leaf Extract on Ethanol-Induced Hemorrhagic Mucosal Lesions in Rats

Ismail

Golbabapour

Hassandarvish

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Polygonum chinense is a Malaysian ethnic plant with various healing effects. This study was to determine preventive effect of aqueous leaf extract of P. chinense against ethanol-induced gastric mucosal injury in rats. Sprague Dawley rats were divided into seven groups. The normal and ulcer control groups were orally administered with distilled water. The reference group was orally administered with 20 mg/kg omeprazole. The experimental groups received the extracts 62.5, 125, 250, and 500 mg/kg, accordingly. After sixty minutes, distilled water and absolute ethanol were given (5 mL/kg) to the normal control and the others, respectively. In addition to histology, immunohistochemical and periodic acid schiff (PAS) stains, levels of lipid peroxidation, malondialdehyde (MDA), antioxidant enzymes, and superoxide dismutase (SOD) were measured. The ulcer group exhibited severe mucosal damages. The experimental groups significantly reduced gastric lesions and MDA levels and increased SOD level. Immunohistochemistry of the experimental groups showed upregulation and downregulation of Hsp70 and Bax proteins, respectively. PAS staining in these groups exhibited intense staining as compared to the ulcer group. Acute toxicity study revealed the nontoxic nature of the extract. Our data provide first evidence that P. chinense extract could significantly prevent gastric ulcer.

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Pharmacological Mechanisms Underlying Gastroprotective Activities of the Fractions Obtained from Polygonum minus in Sprague Dawley Rats

Cited by 40 publications

References 33 publications

The antiulcer effect of <em>Cibotium barometz</em> leaves in rats with experimentally induced acute gastric ulcer

The antiulcer effect of <em>Cibotium barometz</em> leaves in rats with experimentally induced acute gastric ulcer

Acute Toxicity and Gastroprotective Role ofM. pruriensin Ethanol-Induced Gastric Mucosal Injuries in Rats

Gastroprotective Activity ofPolygonum chinenseAqueous Leaf Extract on Ethanol-Induced Hemorrhagic Mucosal Lesions in Rats

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