Pharmacological investigation of antioxidant and anti-inflammatory activities of leaves and branches extracts from Plinia cauliflora (Jaboticaba)

Paula, Priscila de Lima; Lemos, Ari Sérgio de Oliveira; Campos, Lara Melo; Ferreira, Thayná Gomes; Souza, Thalita Freitas de; Queiroz, Lucas Sales; Guedes, Maria Clara Machado Resende; Martins, Mário Machado; Goulart, Luiz Ricardo; Macedo, Gilson Costa; Tavares, Guilherme Diniz; Rocha, Vinícius Novaes; Denadai, Ângelo Márcio Leite; Fabri, Rodrigo Luiz

doi:10.1016/j.jep.2021.114463

Cited by 7 publications

(6 citation statements)

References 48 publications

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“…The essential oils from other plants from the Myrtaceae family also present anti-inflammatory responses, and most of their mechanisms create responses of antioxidant activity, reduction in cell migration, and inhibition of cytokines, nitric oxide, and other inflammatory mediators [ 94 , 95 , 96 ]. In addition, a study with extracts of Plinia cauliflora leaves and branches also showed reduced croton oil-induced ear edema [ 26 ]. This potential was associated with a reduction in nitric oxide and a reduction in leukocyte migration.…”

Section: Resultsmentioning

confidence: 99%

“…Different species of the Myrtaceae family, including P. cauliflora , present a wide variety of organic compounds that have biological activities, such as anti-diarrheal [ 23 ], antimicrobial [ 24 ], and antioxidant [ 25 ]. Previous studies have pointed out the anti-inflammatory potential of ethanolic extracts from leaves and branches [ 26 ] and the anti-promastigote ( Leishmania amazonensis ) activity of the essential oil [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Although promastigotes are not clinically important evolutionary forms, as they are absent in human infection, the products obtained from preparations with P. cauliflora samples can be useful in the in-depth investigation of the leishmanicidal and anti-inflammatory potential of this vegetable product, especially on species related to the development of CL.…”

Section: Introductionmentioning

confidence: 99%

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Potential Effects of Essential Oil from Plinia cauliflora (Mart.) Kausel on Leishmania: In Vivo, In Vitro, and In Silico Approaches

Holanda,

Brito,

Oliveira

et al. 2024

Microorganisms

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In the search for new chemotherapeutic alternatives for cutaneous leishmaniasis (CL), essential oils are promising due to their diverse biological potential. In this study, we aimed to investigate the chemical composition and leishmanicidal and anti-inflammatory potential of the essential oil isolated from the leaves of Plinia cauliflora (PCEO). The chemical composition of PCEO showed β-cis-Caryophyllene (24.4%), epi-γ-Eudesmol (8%), 2-Naphthalenemethanol[decahydro-alpha] (8%), and trans-Calamenene (6.6%) as its major constituents. Our results showed that the PCEO has moderate cytotoxicity (CC50) of 137.4 and 143.7 μg/mL on mice peritoneal exudate cells (mPEC) and Vero cells, respectively. The PCEO was able to significantly decrease mPEC infection by Leishmania amazonensis and Leishmania braziliensis. The value of the inhibitory concentration (IC50) on amastigote forms was about 7.3 µg/mL (L. amazonensis) and 7.2 µg/mL (L. braziliensis). We showed that PCEO induced drastic ultrastructural changes in both species of Leishmania and had a high selectivity index (SI) > 18. The in silico ADMET analysis pointed out that PCEO can be used for the development of oral and/or topical formulation in the treatment of CL. In addition, we also demonstrated the in vivo anti-inflammatory effect, with a 95% reduction in paw edema and a decrease by at least 21.4% in migration immune cells in animals treated with 50 mg/kg of PCEO. Taken together, our results demonstrate that PCEO is a promising topical therapeutic agent against CL.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential Effects of Essential Oil from Plinia cauliflora (Mart.) Kausel on Leishmania: In Vivo, In Vitro, and In Silico Approaches

Holanda,

Brito,

Oliveira

et al. 2024

Microorganisms

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“…The structures of the identified compounds were deduced owing to the HR-MS data as well as by MSn. Epigallocatechin gallate derivatives are characterized by the loss of one or two gallic acid moieties ( m/z 152), leading in this latter case to ion m/z 305, corresponding to the epigallocatechin moiety [ 38 , 39 ] ( Table 1 ). Other condensed tannins in P. heyniae were prodelphynidine gallate derivatives, compounds in fact present the molecular formula of C 37 H 30 O 18 , which generate fragment because of −152 Da ascribable to gallic acid moiety.…”

Section: Resultsmentioning

confidence: 99%

“…These compounds have been identified in the fruits of Terminalia chebula and LC methods have been proposed for their identification [ 43 ]. A series of condensed tannins formed by units of epigallo/gallo catechin with or without gallic acid esterification have been also identified [ 39 , 44 , 45 ]. Furthermore, the peak presenting molecular formula of C 44 H 36 O 22 was tentatively assigned to the Assamicain chalcan flavan dimer previously identified in Camelia sinensis [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Screening, Antioxidant, and Enzyme Inhibitory Properties of Three Prangos Species (P. heyniae, P. meliocarpoides var. meliocarpoides, and P. uechtritzii) Depicted by Comprehensive LC-MS and Multivariate Data Analysis

et al. 2022

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The aim of the present study was to identify/quantify bioactive compounds and determine the antioxidant activity and enzyme inhibitory effects of various solvent extracts (n-hexane, ethyl acetate, methanol, and water) of Prangos heyniae H. Duman and M.F. Watson, Prangos meliocarpoides var. meliocarpoides, and Prangos uechtritzii Boiss. and Hausskn. This is the first time such a report has been designed to validate the phytochemical composition and bioactivity (especially enzyme inhibitory properties) of these plants. A combined approach of liquid chromatography (LC) with mass spectrometry (HR-MS and MSn) allowed to identify that P. heyniae contains condensed tannins; P. meliocarpoides is rich in hydrolysable tannins; and P. uechtritzii possesses coumarins, flavonoids, and hydroxycinnamic acids. Different extracts were tested for antioxidant activities using a battery of assays, such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), total antioxidant capacity (TAC) (phosphomolybdenum), and metal chelating. Enzyme inhibitory effects were investigated using acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase as target enzymes. The obtained results depended on the extraction solvents used for each Prangos species. The methanol extract of P. meliocarpoides var. meliocarpoides exhibited significant radical scavenging activity (DPPH: 52.27 mg Trolox equivalent (TE)/g; ABTS: 92.84 mg TE/g), the most potent-reducing potential (CUPRAC: 154.04 mg TE/g; FRAP: 104.34 mg TE/g), and high TAC (2.52 mmol TE/g). Moreover, the strongest BChE (7.97 mg galantamine equivalent/g), α-amylase (0.46 mmol acarbose equivalent/g), and tyrosinase (81.15 mg kojic acid equivalent/g) inhibitory effects were observed for the hexane extract of P. meliocarpoides var. meliocarpoides. Correlation analysis showed a significant positive correlation between hydrolysable tannins and antioxidant activities. The same trend was also observed between the same class of compounds and the inhibitory effects on enzymatic activities. These results suggest a principal role of hydrolysable tannins in the observed bioactivities of Prangos. Our results suggested that the tested Prangos species could be valuable as sources of natural agents in the development of health-promoting applications.

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“…A natural group of secondary metabolites of plants considered useful for its beneficial health effects in humans is phenolic compounds [ 9 ]. They also possess biological properties such as antioxidant, antibacterial, and anti-inflammatory effects [ 8 , 10 ]. However, some species to which the community has assigned a medical use are poorly investigated, and their phytochemical profile and biological activity of phenolic fractions remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Extraction of Phenolic Compounds from Adenaria floribunda Stem: Economic Assessment

Lopeda-Correa

Valdés-Duque

Osorio-Tobón

2022

Foods

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Adenaria floribunda is a native species found in tropical regions of South America used as a traditional medicine. Ultrasound-assisted extraction (UAE) is an extraction process known to increase the extraction yield, reduce extraction times, and use low temperatures. This study aims to obtain water-based extracts from A. floribunda stems using UAE, hot water extraction (HWE), and Soxhlet extraction and perform an economic analysis. The global extraction yield (GEY) and total phenolic compounds (TPC) of extracts ranged from 5.24% to 10.48% and from 1.9 ± 0.44 mg GAE g−1 DW to 6.38 ± 0.28 mg GAE g−1, respectively. Gallic acid, catechin, and ferulic acid were identified in the extract using HPLC-UV. Results indicate that Soxhlet extraction has the best performance regarding GEY and TPC. However, after performing an economic assessment, the cost of manufacturing (COM) of Soxhlet extraction (US$ 5.8 flask−1) was higher than the UAE (US$ 3.86 flask−1) and HWE (US$ 3.92 flask−1). The sensitivity results showed that obtaining extracts from A. floribunda by UAE and HWE is economically feasible when the selling price is above US$ 4 flask−1. Soxhlet extraction is a feasible technique when the selling price is above US$ 7 flask−1.

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Pharmacological investigation of antioxidant and anti-inflammatory activities of leaves and branches extracts from Plinia cauliflora (Jaboticaba)

Cited by 7 publications

References 48 publications

Potential Effects of Essential Oil from Plinia cauliflora (Mart.) Kausel on Leishmania: In Vivo, In Vitro, and In Silico Approaches

Potential Effects of Essential Oil from Plinia cauliflora (Mart.) Kausel on Leishmania: In Vivo, In Vitro, and In Silico Approaches

Phytochemical Screening, Antioxidant, and Enzyme Inhibitory Properties of Three Prangos Species (P. heyniae, P. meliocarpoides var. meliocarpoides, and P. uechtritzii) Depicted by Comprehensive LC-MS and Multivariate Data Analysis

Ultrasound-Assisted Extraction of Phenolic Compounds from Adenaria floribunda Stem: Economic Assessment

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