Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or joint replacement for hip, pelvic and long bone fractures

Cochrane in CORR®: Pharmacological Interventions for the Prevention of Bleeding in People Undergoing Definitive Fixation or Joint Replacement for Hip, Pelvic and Long Bone Fractures

“…The Cochrane review on this topic we’re covering here by Gibbs et al [4] included 13 RCTs (929 participants) comparing medications to reduce bleeding during fracture fixation surgery. Although the authors intended to report on other medications such as desmopressin, recombinant factor VIIa and factor XIII, as well as fibrinogen, only intravenous and topical TXA had sufficient information to pool data.…”

“…This can mean anything from the study starting to enroll patients a day before registration to the study being registered after the analysis was complete, which are vastly differing situations. Twenty-five studies were classified as “awaiting classification” because their registration status was unknown [4].…”

Cochrane Corner

“…Additional pharmacological agents that have been considered in this review to reduce bleeding include other antifibrinolytics, coagulation factor supplementation, and sealants. 2…”